COMPLEXATION

Question 1

result from a donor-acceptor mechanism or Lewis acid-base reaction

Answer 1

complex or coordiantion compounds

Question 2

non metal / ionic compound

Answer 2

electron DONOR

Question 3

metal / neutral atom

Answer 3

electron ACCEPTOR

Question 4

Lewis acid + Lewis base reaction

Answer 4

complexation

Question 5

types of complexation

Answer 5

metal-ion
organic molecular
inclusion/occlusion

Question 6

TYPES OF COMPLEXATION

1. inorganic
2. chelate

Answer 6

Metal ion complexes

Question 7

METAL ION COMPLEX

contains 2 or more donor groups combined with a metal

e.g. chlorophyll, hemoglobin, albumin

Answer 7

chelate

Question 8

METAL ION COMPLEX

EDTA means

Answer 8

ethylenediaminetetraacetic acid

Question 9

METAL ION COMPLEX

• a hexadentate
• can sequester iron and copper
• complexes with calcium

Answer 9

EDTA

Question 10

METAL ION COMPLEX

EDTA can sequester ____ and ____

Answer 10

iron & copper

Question 11

METAL ION COMPLEX

EDTA complexes with ____

Answer 11

Calcium

Question 12

TYPES OF COMPLEXATION

• constituents held by weak forces or H-bonds
• Disulfiram-Iodine Complex
• Caffeine Complexes
• Polymer Complexes

Answer 12

Organic Molecular Complexes

Question 13

ORGANIC MOLECULAR COMPLEXES

are held by ____ or ____

Answer 13

weak forces or H bonds

Question 14

METAL ION COMPLEXES

an ion or molecule attached to a metal by coordinate bonding

Answer 14

ligand

Question 15

METAL ION COMPLEXES

makes use of a ligand

Answer 15

inorganic complexes

Question 16

METAL ION COMPLEXES | INORGANIC COMPLEXES

each ligand donates a ____ to form a coordinate covalent link

Answer 16

pair of electrons

Question 17

METAL ION COMPLEXES | INORGANIC COMPLEXES

plays an important part in coordination compounds in which sufficient bonding orbitals are not ordinarily available in the metal ion

Answer 17

hybridization

Question 18

METAL ION COMPLEXES | INORGANIC COMPLEXES

suggested the possibility of hybridization to account for the quadrivalence

Answer 18

Paul

Question 19

METAL ION COMPLEXES | INORGANIC COMPLEXES

ligands lie ABOVE a partially filled orbital

Answer 19

outer-sphere complexes

Question 20

METAL ION COMPLEXES | INORGANIC COMPLEXES

ligands lie BELOW a partially filled orbitals

Answer 20

inner-sphere complexes

Question 21

METAL ION COMPLEXES | CHELATE

came from the greek word

Answer 21

kelos, means claw

Question 22

METAL ION COMPLEXES | CHELATE

when the ligand provides one group for attachment to the central ion the chelate is called

Answer 22

monodentate

Question 23

METAL ION COMPLEXES | CHELATE

Pilocarpine behaves as a

Answer 23

monodentate

Question 24

METAL ION COMPLEXES | CHELATE

molcules with two donor groups

Answer 24

bidentate

Question 25

# **METAL ION COMPLEXES | CHELATE** molecules with **three donor groups**

Answer 25

tridentate

Question 26

# **METAL ION COMPLEXES | CHELATE** two extremely important compounds that are **naturally occuring chelates** involved in the **life processes** of **plants** and **animals**

Answer 26

chlorophyll hemoglobin

Question 27

# **METAL ION COMPLEXES | CHELATE** in the process of **sequestration**, the **chelating agent** and the **metal ion** form a ____ compound

Answer 27

water soluble

Question 28

# **ORGANIC MOLECULAR COMPLEXES** the **difference** between **complexation** and the **formation of organic compounds** has been shown by

Answer 28

Clapp

Question 29

# **ORGANIC MOLECULAR COMPLEXES** **resonance** makes the **main contribution** to complexation

Answer 29

charge transfer complex

Question 30

# **ORGANIC MOLECULAR COMPLEXES** **London dispersion forces** and **dipole-dipole interactions** contribute more to the **stability** of the complex

Answer 30

donor-acceptor complex

Question 31

# **ORGANIC MOLECULAR COMPLEXES** complexes **bound together** by **van der Waals forces**, **dipole-dipole interactions** and **hydrogne bonding** but **lacking charge transfer** are known as

Answer 31

molecular complexes

Question 32

# **ORGANIC MOLECULAR COMPLEXES** a form of **charge transfer** | charge transfer complexes

Answer 32

disulfiram-iodine complex

Question 33

# **ORGANIC MOLECULAR COMPLEXES** complexes with **anions** and **organic acids**

Answer 33

Caffeine complexes

Question 34

# **ORGANIC MOLECULAR COMPLEXES | CAFFEINE COMPLEXES** with **anions**

Answer 34

more soluble

Question 35

# **ORGANIC MOLECULAR COMPLEXES | CAFFEINE COMPLEXES** with **organic acids**

Answer 35

less soluble

Question 36

# **ORGANIC MOLECULAR COMPLEXES** * PEG, polystyrene, Carboxymethylcellulose * povidone iodine (PVP) + aromatic compounds

Answer 36

polymer complexes

Question 37

a complex in which one chemical compound (**host**) forms a **cavity** in which **molecules** of **second** compound (**guest**) are **entrapped**

Answer 37

inclusion compounds

Question 38

# **INCLUSION COMPOUNDS** also known as

Answer 38

occlusion

Question 39

# **INCLUSION COMPOUNDS** results from ____ of the molecules

Answer 39

architecture

Question 40

# **INCLUSION COMPOUNDS** a molecule of **guest** compound gets **entrapped** within the **cagelike structure** formed by association of several molecules of host | e,g, **WARFARIN SODIUM**

Answer 40

clathrates

Question 41

# **INCLUSION COMPOUNDS | CLATHRATES** **not involved** in this complexes

Answer 41

chemical bonds

Question 42

# **INCLUSION COMPOUNDS | CLATHRATES** **are of importance** in these complexes

Answer 42

molecular size of the encaged component

Question 43

# **INCLUSION COMPOUNDS** **host** component **crystallizes** to **form** a **channel-like structure** into which **guest** molecule **can fit** | e.g. **CHOLIC ACID**

Answer 43

channel lattice complexes

Question 44

# **INCLUSION COMPOUNDS | CHANNEL LATTICE COMPLEXES** **permits** the **resolution** of **optical isomers**

Answer 44

stereospecificity

Question 45

# **INCLUSION COMPOUNDS** **entrapment** of **single guest** molecules into the **cagelike structure** formed from a **single host** molecule | e.g. **CYCLODEXTRIN**

Answer 45

monomolecular inclusion compounds

Question 46

# **INCLUSION COMPOUNDS | MONOMOLECULAR INCLUSION COMPOUNDS** * **cyclic oligomers** of **glucose** that **can form water-soluble inclusion complexes** with **small** molecules and **portion** of **large** compounds * **do not elicit immune responses** and have **low toxicities** in **animals** and **humans** * used in **improving the boavailability of drugs**

Answer 46

cyclodextrin

Question 47

# **INCLUSION COMPOUNDS** atoms are arranged in **3D** to **produce cages** and **channels** | e.g. **SYNTHETIC ZEOLITES**, **DEXTRINS**, **SILICA GELS**

Answer 47

Macromolecular inclusion compounds

Question 48

# **INCLUSION COMPOUNDS** **Macromolecular** inclusion compounds are commonly called as

Answer 48

molecular sieves

Question 49

# **INCLUSION COMPOUNDS** the **guest** molecule is **diffused between layers** of carbon atom, **hexagonally oriented** to **form alternate layers** of **guest** and **host** molecules | e.g. **MONTMORILLONITE**, **GRAPHITE**

Answer 49

Layer type or Intercalation compounds

Question 50

# **INCLUSION COMPOUNDS** **Layer** type is also known as

Answer 50

intercalation compounds

Question 51

# **INCLUSION COMPOUNDS | LAYER / INTERCALATION** **principal** component of **bentonite**

Answer 51

montmorillonite