Flashcards in Congenital Adrenal Hyperplasia Deck (12):
hyponatremic hyperkalemic, metabolic acidosis indicates ______
mineralocorticoid deficiency --> adrenal crisis/salt-wasting crisis
Tx for salt wasting crisis
iv isotonic saline, dextrose to lower potassium, high dose hydrocortisone to provide vascular support and slow Na loss
how does sugar reduce potassium?
leading diagnosis of salt-wasting crisis in first weeks of life
21 hydroxylase deficient congenital adrenal hyperplasia
inborn error of cortisol synthesis that result in compensatory high ACTH resulting in adrenal hyperplasia in fetal life and beyond
T/F most clinical manifestations of CAH are caused by excess/deficiency of mineralocorticoids and sex hormones vs by glucocorticoids
T --> even though all are made ineffiecient
21OH impairment leads to reduced/increased mineralocorticoid production, reduced/increased androgen production, and reduced/increased cortisol production.
reduced, increased, reduced
Mineralocorticoid excess/deficiency causes hypertension and hypokalemia
Mineralocorticoid excess/deficiency causes saltwasting, hyponatremia, hyperkalemia, dehydration
T/F effects of mineralocorticoid excess/deficiency are independent of sex.
Why are there about 20% more adult females than males with CAH?
harder to identify boys b/c testosterone doesn't result in clinical features --> die from saltwasting without dx of CAH