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Flashcards in Feast or Famine Deck (16):
1

leptin

signal from adipose to hypothalamus--> increase alpha msh --> satiety, thermogenesis, fatty acid oxidation, insulin sensitivity

2

alpha msh works through which receptor?

mc4r - melanocortin4

3

deletion of the mc4r would result in what?

weight gain because of loss of leptin feedback

4

T/F G6 phosphatase is in the muscle and liver

F --> only liver; muscle does not export glucose

5

What is the consequence of losing leptin?

loss of feedback inhibition on brain --> obesity

6

T/F obesity can be monogenically determined

T--> can have congenital absence of leptin or mcr4r but for most it is an interplay of multiple genes and environment

7

T/F the larger your waist size, the greater your risk of coronary heart disease

T

8

Orlistat MOA

pancreatic lipase inhibitor --> reduced fat absorption --> steatorrhea

9

T/F RYGB reverses sleep apnea

T

10

T/F RYGB decreases cancer

T

11

T/F RYGB decreases diabetes

T

12

Adverse effects of RYGB

postop complications, vitamin/iron/ca deficiency, flatulence, recurrent severe hypoglycemia

13

T/F newborns produce more ketones than adults during fasting

T --> better at handling ketones

14

cachexia

wasting syndrome is loss of weight, muscle atrophy, fatigue, weakness, and significant loss of appetite --> inflammatory condition

15

Tx of cachexia

controlled refeeding, dx underlying diseases, anabolic tx: megesterol, cannabis, myostatin inhibitors (follistatin), ghrh

16

neel's thrifty gene hypothesis

we are selected to be energy efficient during fasting