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Flashcards in Feast or Famine Deck (16)
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1
Q

leptin

A

signal from adipose to hypothalamus–> increase alpha msh –> satiety, thermogenesis, fatty acid oxidation, insulin sensitivity

2
Q

alpha msh works through which receptor?

A

mc4r - melanocortin4

3
Q

deletion of the mc4r would result in what?

A

weight gain because of loss of leptin feedback

4
Q

T/F G6 phosphatase is in the muscle and liver

A

F –> only liver; muscle does not export glucose

5
Q

What is the consequence of losing leptin?

A

loss of feedback inhibition on brain –> obesity

6
Q

T/F obesity can be monogenically determined

A

T–> can have congenital absence of leptin or mcr4r but for most it is an interplay of multiple genes and environment

7
Q

T/F the larger your waist size, the greater your risk of coronary heart disease

A

T

8
Q

Orlistat MOA

A

pancreatic lipase inhibitor –> reduced fat absorption –> steatorrhea

9
Q

T/F RYGB reverses sleep apnea

A

T

10
Q

T/F RYGB decreases cancer

A

T

11
Q

T/F RYGB decreases diabetes

A

T

12
Q

Adverse effects of RYGB

A

postop complications, vitamin/iron/ca deficiency, flatulence, recurrent severe hypoglycemia

13
Q

T/F newborns produce more ketones than adults during fasting

A

T –> better at handling ketones

14
Q

cachexia

A

wasting syndrome is loss of weight, muscle atrophy, fatigue, weakness, and significant loss of appetite –> inflammatory condition

15
Q

Tx of cachexia

A

controlled refeeding, dx underlying diseases, anabolic tx: megesterol, cannabis, myostatin inhibitors (follistatin), ghrh

16
Q

neel’s thrifty gene hypothesis

A

we are selected to be energy efficient during fasting