Pediatric Endocrinology Flashcards Preview

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Flashcards in Pediatric Endocrinology Deck (28):
1

T/F menarche marks the beginning of the reduction in girls' growth rate

T

2

Early indicator of constitutional delay

delayed dental development

3

GH

Pituitary GH --> Liver IGF1 --> metabolic and bone effects --> used in screening

4

T/F Most SGA catch up in weight/length

T --> 10-15% of small for gestational age do not catch up by age 2

5

Endocrine disorders that lead to growth changes

hypothyroidism, cortisol excess, GH deficiency

6

Bone Age Xray

Width of epiphyses spans full width of finger and are beginning to fuse --> delayed bone age = late bloomer or disease process //normal bone age but short stature = genetically short stature

7

T/F Random GH evaluation is useful

F --> GH is pulsatile, mainly at night, and difficult to measure

8

Screening tests for growth hormone

IGF1 and IGFBP3

9

T/F Low IGF1 can be seen in malnutrition

T

10

T/F turner's syndrome patients have close to normal intelligence

T

11

Elevated ESR may indicate:

Crohn's disease

12

T/F can tell difference between girls/boys hormonalyl at puberty

T

13

T/F can tell difference between girls/boys hormonally at childhood

F --> GnRH suppression

14

What hormone leads to bone fusion?

estrogen

15

Breast enlargement in neonates

due to maternal estrogen --> usually subsides

16

T/F both androgen and estrogen play a role in growth surge

T --> androgens are converted to estrogen for bone growth so too much androgens will lead to growth surge

17

DHEA-S is specific to what organ?

adrenal --> high DHEAS early might suggest early awakening of adrenal

18

elevated 17 hydroxy progesterone might suggest:

CAH

19

Below age of ___ in a boy with testicular enlargement is early.

9 (also concerned about no testicular development until after 14)

20

Central causes of precocious puberty

idiopathic, CNS pathology, hamartoma

21

Peripheral causes of precocious puberty

ovarian cysts, McCune-Albright, Exogenous

22

McCune-Albright

bone, skin pigmentation, precocious puberty

23

most common organic central cause of precious puberty

hamartoma --> in pineal region

24

Tx of precocious puberty

Lupron, Histrelin Implant

25

Histrelin Implant/lupron MOA

continuous GnRH --> pituitary shuts down LH/FSH release --> delays puberty

26

Tanner 1 means ___

no development of breasts/pubic hair

27

Onset of puberty is related to tanner ___

stage 4 --> raised areola

28

How many babies born with congenital hypothyroidism

1/4000 --> preventable mental retardation