Pediatric Endocrinology Flashcards Preview

Endocrine > Pediatric Endocrinology > Flashcards

Flashcards in Pediatric Endocrinology Deck (28)
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1
Q

T/F menarche marks the beginning of the reduction in girls’ growth rate

A

T

2
Q

Early indicator of constitutional delay

A

delayed dental development

3
Q

GH

A

Pituitary GH –> Liver IGF1 –> metabolic and bone effects –> used in screening

4
Q

T/F Most SGA catch up in weight/length

A

T –> 10-15% of small for gestational age do not catch up by age 2

5
Q

Endocrine disorders that lead to growth changes

A

hypothyroidism, cortisol excess, GH deficiency

6
Q

Bone Age Xray

A

Width of epiphyses spans full width of finger and are beginning to fuse –> delayed bone age = late bloomer or disease process //normal bone age but short stature = genetically short stature

7
Q

T/F Random GH evaluation is useful

A

F –> GH is pulsatile, mainly at night, and difficult to measure

8
Q

Screening tests for growth hormone

A

IGF1 and IGFBP3

9
Q

T/F Low IGF1 can be seen in malnutrition

A

T

10
Q

T/F turner’s syndrome patients have close to normal intelligence

A

T

11
Q

Elevated ESR may indicate:

A

Crohn’s disease

12
Q

T/F can tell difference between girls/boys hormonalyl at puberty

A

T

13
Q

T/F can tell difference between girls/boys hormonally at childhood

A

F –> GnRH suppression

14
Q

What hormone leads to bone fusion?

A

estrogen

15
Q

Breast enlargement in neonates

A

due to maternal estrogen –> usually subsides

16
Q

T/F both androgen and estrogen play a role in growth surge

A

T –> androgens are converted to estrogen for bone growth so too much androgens will lead to growth surge

17
Q

DHEA-S is specific to what organ?

A

adrenal –> high DHEAS early might suggest early awakening of adrenal

18
Q

elevated 17 hydroxy progesterone might suggest:

A

CAH

19
Q

Below age of ___ in a boy with testicular enlargement is early.

A

9 (also concerned about no testicular development until after 14)

20
Q

Central causes of precocious puberty

A

idiopathic, CNS pathology, hamartoma

21
Q

Peripheral causes of precocious puberty

A

ovarian cysts, McCune-Albright, Exogenous

22
Q

McCune-Albright

A

bone, skin pigmentation, precocious puberty

23
Q

most common organic central cause of precious puberty

A

hamartoma –> in pineal region

24
Q

Tx of precocious puberty

A

Lupron, Histrelin Implant

25
Q

Histrelin Implant/lupron MOA

A

continuous GnRH –> pituitary shuts down LH/FSH release –> delays puberty

26
Q

Tanner 1 means ___

A

no development of breasts/pubic hair

27
Q

Onset of puberty is related to tanner ___

A

stage 4 –> raised areola

28
Q

How many babies born with congenital hypothyroidism

A

1/4000 –> preventable mental retardation