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Flashcards in Crossover Deck (45)
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1

Risk is a product of the following except:

A. Safety
B. Toxicity
C. Exposure

A

2

Important potential stages in the development of toxicity include the following except:

A. Delivery
B. Interaction with the target molecule
C. Cellular dysfunction and injury
D. Dysrepair

B

3

The destruction of cell maintenances involves:

A. Destruction of ATP synthesis
B. Dysregulation of gene expression
C. Direct Injury
D. Dysregulation of ongoing cellular activity

A

4

Oxidative stress is an example of which mechanism of toxic action:

A. Impairment of internal maintenance
B. Impairment of external maintenance
C. Toxication
D. Alteration of regulatory or maintenance function of the cell

A

5

Actions of endocrine-disrupting substances are classified as:

A. Impaired internal maintenance
B. Impaired external maintenance
C. Dysregulation of gene expression
D. Dysregulation of ongoing cellular activity

C

6

The stage of disrepair includes the following except:

A. Apoptosis
B. Necrosis
C. Fibrosis
D. Cancer

A

7

The kind of exposure that is the most effective for the toxicant to enter the body is:

A. Intramuscular
B. Subcutaneous
C. Inhalational
D. Ingestional

C

8

The most common form of dermatological manifestation of allergic drug reactions:

A. Melasma
B. Angioedema
C. Morbiliform rash
D. Papular rash

C

9

A delayed adverse drug reaction to fertility drugs.

A. Ovarian cancer
B. Uterine benign tumor
C. Both

A

10

Gives rise to drug fever

A. Rifampicin
B. Carbamazepine
C. Cefaclor
D. Allopurinol
E. A and B.
F. A and D

E

11

Serum sickness is more likely to occur in:

A. Rifampicin and Carbamazepine
B. Rabies vaccine and IV Immunoglobin
C. Allopurinol and Cefaclor
D. None of the above

B

12

Pharmacogenetic variations that may appear as unusual response to a drug:

A. Warfarin resistance
B. Hemolytic anemia after taking acetanilide
C. Malignant hyperthermia following use of halothane
D. All of the above

C

13

The prodrug used in pharmacogenetic study of CYP 2D6:

A. Deprisoprine
B. Parathion
C. Dihydropyrimidine dehydrogenase
D. Nortiptyline

A

14

A fatal result of drug-drug interaction of imidazoles and antihistamines causes:

Torsades de pointes

15

Genetic abnormality noted with Fish odor syndrome.

N-oxidation trimethylamine is genetically controlled. A problem in this mechanism leads to the accumulation of TMA. This leads to the fish odor syndrome.

16

Important levels in the development of toxicity EXCEPT

A. Delivery
B. Interaction with the target molecule
C. Cellular dysfunction/injury
D. Dysrepair

B

17

Which is part of cell dysregulation?

A. Oxidative stress
B. Disruption of gene expression
C. Disruption of ATP synthesis
C. All of the above

B

18

Enzyme that inhibits/stimulates is an example of this mechanism of action:

A. Impairment of intracellular maintenance
B. Impairment of extracellular maintenance
C. Dysregulation of gene expression
D. Dysregulation of ongoing cellular management

D

19

Spectrum of toxic effects include:

A. Delayed reaction after initial exposure
B. Idiosyncratic reactions, immunologically modulated
C. Allergies, genetically-determined
D. AOTA

D

20

True of pharmacokinetic drug interactions:

A. Affect the site of action
B. Affect the activity of metabolic enzyme systems
C. IV incompatibility
D. AOTA

D

21

The following statements are true of the concept of toxicology, except

A. It is the study that involves adverse effects of drugs in their therapeutic dose
B. The toxicity of chemicals are inherent in nature
C. The risk to development of poisoning varies with the degree of exposure
D. Safety is the probability that harm will not occur under specified conditions

A

22

Example(s) of toxic actions affecting cellular dysregulation include(s) the ff:

a. Inhibit ATP synthesis
b. Inhibit gene expression
c. Inhibit membrane function
d. A and B only
e. AOTA

B

23

The following are important potential stages in development of toxicity except:

a. Delivery
b. Cell dysfunction/injury
c. Interaction with target molecule
d. A and B only
e. AOTA

C

24

The factors that affects response to toxic agents

a. Duration of exposure
b. Chemical properties of substance
c. Health status of individuals
d. A and B only
e. AOTA

E

25

On the last stage of potential toxicity the ff. processes are involved:

a. Fibrosis
b. Necrosis
c. Apoptosis
d. A and B only
e. AOTA

D

26

True about the nature of toxic action

a. The toxic action of a drug is not necessarily an exaggeration of its therapeutic effect
b. The intensity of a toxic effect depends on its concentration at the target organ
c. The toxic action of a drug may be brought about by its metabolites
d. A and B only
e. AOTA

E

27

True regarding toxic effects produced by chemicals:

a. Chemical allergy is a genetically induced adverse reaction
b. Delayed reaction is an extension of the immediate effects
c. Substances can have both local and systemic effects
d. A and B only
e. AOTA

D

28

Mechanisms involving distribution that the body uses to protect itself from toxic effects of chemicals include:

a. First pass effect
b. Presence of specialized barriers
c. Detoxification
d. A and B only
e. AOTA

E

29

Risk is a product of the ff:

a. Toxicity
b. Exposure
c. Safety
d. A and B only
e. AOTA

D

30

Which of the following is/are true of drug interactions.

a. These are interactions between a drug and another substance.
b. These interactions usually occur in vivo.
c. These are not beneficial.
d. A & B are true.
e. All of the above.

D