Samplex 2015 Set C

Question 1

Mechanism of action of direct adrenergic agonists

A. Increases synthesis of NE
B. Binds and activates adrenergic receptors
C. Inhibition of MAO
D. Inhibits reuptake from synaptic cleft

Answer 1

B

Question 2

Adrenergic receptor on JG Cells

A. Alpha 1
B. Alpha 2
C. Beta 1
D. Beta 2

Answer 2

C

Question 3

this drug with can improve contractility but can also cause vasodilatation should not be taken as a sole adrenergic drug in patients with heart failure and hypotension

A. Dobutamine
B. Dopamine
C. Norepinephrine
D. Phenylephrine

Answer 3

B

Question 4

Selective beta-2 adrenergic agonists are useful in which of the following conditions

A. Hypertension
B. Heart failure
C. Preterm labor
D. Arrythmia

Answer 4

C

Question 5

Sympathomimetic effects in the CNS include the following EXCEPT:

A. Excessive urge to sleep in inappropriate situations
B. Elevation of mood
C. Euphoria
D. Psychosis

Answer 5

A

Question 6

A beta-1 selective blocker with partial activity which will minimize, if not prevent precipitation of asthma and bradycardia.

A. Acetabulol
B. Timolol
C. Propanolol
D. Esmolol

Answer 6

A

Question 7

Incorrect association between histamine and its distribution in organs.

a. H1 – extravascular smooth muscle
b. H2 – gastric parietal cells
c. H3 – CNS
d. H4 - myocardial cells

Answer 7

D

Question 8

not H1 antagonist

a. cimetidine
b. chlorophenydramine
c. diphenhydramine
d. loratidine

Answer 8

A

Question 9

Incorrect about Kallikrein-kininogen-kinin/KKK system:

a. Bradykinin causes vasodilation and cough
b. High molecular weight kinninogen is important in activation of intrinsic clotting pathway
c. Aprotinin which inhibits kallikrein à reverse bleeding due to heparin
d. Tissue damage cannot activate KKK

Answer 9

D

Question 10

Not a function of 5ht

a. Regulation of GI motility and peristalsis
b. Bronchodilation
c. Central chemical transmitter for tryptaminergic neurons of the brain
d. Precursor of melatonin

Answer 10

B

Question 11

Incorrect match between the 5HT receptor antagonist / agonist drugs with their clinical use

a. 5HT3 Antagonist / ondansetron – nausea, vomiting
b. 5HT4 agonist / Cisapride – anxiety/depression
c. 5HT 1D agonist / Sumatripan – migraine
d. 5HT2A Antagonist / Ketaneserin – hypertension

Answer 11

B

Question 12

Example of non-selective 5HT receptor antagonist:

a. Buspirone
b. Trazodone
c. Ergotamin
d. Ketanserin

Answer 12

C

Question 13

The gastrointestinal bleeding from aspirin is considered:

a. side effect
b. extension effect
c. drug toxicity
d. medication error

Answer 13

A

Question 14

8. Autacoids involved in inflammatory reaction, EXCEPT

a. Histamine
b. Bradykinin
c. Serotonin
d. Prostanoids
e. Angiotensin II

Answer 14

E

Question 15

The following physiologic effects are mediated by histamine EXCEPT

a. Vasodilatation
b. Increased vascular permeability
c. Relaxation of intestinal smooth muscles
d. Stimulation of sensory nerve endings

Answer 15

C

Question 16

H1 blockers (traditional / older antihistamines) have the following effects:

a. Promote sedation
b. Relieve allergic manifestations on the skin and mucous membrane
c. Emesis
d. All of the above
e. A and B only

Answer 16

D

Question 17

Which of the following is least sedating

a. Loratadine
b. Chlorpenamine
c. Diphenhydramine
d. Clemastine

Answer 17

A

Question 18

What are the therapeutic uses of the H1 blockers? ALL EXCEPT

a. As a sleeping aid
b. For countering motion sickness
c. To moisten the mouth and throat
d. To relieve itching and rashes in allergic disease

Answer 18

C

Question 19

Body functions where 5-HT in involved

a. Fertility
b. Feeding
c. Sleeping
d. Mentation
e. All of the above

Answer 19

E

Question 20

The enzyme responsible for converting tryptophan to serotonin belongs to what class

a. Lipoxygenase
b. Hydroxylase
c. Peroxidase
d. Transferase

Answer 20

B

Question 21

Prostanoids have the following actions/clinical significance

a. Platelet function
b. Inflammatory reaction
c. Reproduction
d. A and B only
e. All of the above

Answer 21

E

Question 22

Which of the following anti-inflammatory agents is unique that it binds to its receptor irreversibly?

a. Ibuprofen
b. Mefenamic acid
c. Acetaminophen
d. Aspirin

Answer 22

D

Question 23

An example of lipoxygenase inhibitor is:

a. Celecoxib
b. Zileuton
c. Montelukast
d. Misoprostol

Answer 23

B

Question 24

Histamine

a. has powerful effects on smooth and cardiac muscles
b. endothelial cells and nerves
c. more effect on guinea pigs than humans
d. gastric acid secretion
e. AOTA

Answer 24

E

Question 25

Traditional antihistamines with sedative effect include a. Diphenhydramine b. Loratadine c. Cetirizine d. AOTA e. A&C only

Answer 25

A

Question 26

Actions mediated by H1 blocker but not through H1 receptor a. Bronchia; and GI smooth muscle relaxation b. Endothelial constriction resulting in increased muscular permeability c. Dilation of vascular smooth muscle from NO from EDRF d. sedative, antinausea effect e. AOTA

Answer 26

D

Question 27

Serotonin is found in: a. Enterochromaffin cells, 90% of the body b. Platelets which are able to concentrate the amine by means of active SERT c. Nerve endings, particularly brain serotonergic neurons as transmitter. d. AOTA e. B&C only

Answer 27

D

Question 28

5HT in brain serotonergic neurons are involved in a. mood, depression, anxiety b. sleep, apetite and vomiting c. pain, temperature regulation, migraine d. AOTA e. A and C only

Answer 28

D

Question 29

Selective serotonin include: a. Sumatriptan, 5HT1A/1D antagonist, for migraines and cluster headaches b. buspirone, 5HT1 agonist used as a widely accepted anxiolitic c. Ondesterone, 5HT3 for chemotherapy antiemesis d. AOTA e. B&C only

Answer 29

B

Question 30

Angiotensin II and III effects are reversed by a. renin inhibitors of synthesis or release b. angiotensin converting enzyme inhibitors c. kininase II inhibitors d. angiotensin receptor antagonist e. AOTA

Answer 30

E

Question 31

The potency of ACE inhibitors like captopril can be explained by a dual action: a. inhibition of synthesis of a powerful vasoconstrictor b. inhibition of destruction of a powerful vasodilator c. stimulation of synthesis of a powerful vasodilator d. AOTA e. A and B only

Answer 31

E

Question 32

Prostaglandin sunthesis is blocked through several pathways a. lipoxygenase pathway, site of action of leukotriene inhibitors b. cyclooxygenase pathway, site of action of aspirin and NSAIDS c. Phospholipase enzyme, site of direct action of corticosteroids d. AOTA e. B&C only

Answer 32

B