Samplex 2015 Set C Flashcards Preview

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Flashcards in Samplex 2015 Set C Deck (32)
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1

Mechanism of action of direct adrenergic agonists

A. Increases synthesis of NE
B. Binds and activates adrenergic receptors
C. Inhibition of MAO
D. Inhibits reuptake from synaptic cleft

B

2

Adrenergic receptor on JG Cells

A. Alpha 1
B. Alpha 2
C. Beta 1
D. Beta 2

C

3

this drug with can improve contractility but can also cause vasodilatation should not be taken as a sole adrenergic drug in patients with heart failure and hypotension

A. Dobutamine
B. Dopamine
C. Norepinephrine
D. Phenylephrine

B

4

Selective beta-2 adrenergic agonists are useful in which of the following conditions

A. Hypertension
B. Heart failure
C. Preterm labor
D. Arrythmia

C

5

Sympathomimetic effects in the CNS include the following EXCEPT:

A. Excessive urge to sleep in inappropriate situations
B. Elevation of mood
C. Euphoria
D. Psychosis

A

6

A beta-1 selective blocker with partial activity which will minimize, if not prevent precipitation of asthma and bradycardia.

A. Acetabulol
B. Timolol
C. Propanolol
D. Esmolol

A

7

Incorrect association between histamine and its distribution in organs.

a. H1 – extravascular smooth muscle
b. H2 – gastric parietal cells
c. H3 – CNS
d. H4 - myocardial cells

D

8

not H1 antagonist

a. cimetidine
b. chlorophenydramine
c. diphenhydramine
d. loratidine

A

9

Incorrect about Kallikrein-kininogen-kinin/KKK system:

a. Bradykinin causes vasodilation and cough
b. High molecular weight kinninogen is important in activation of intrinsic clotting pathway
c. Aprotinin which inhibits kallikrein à reverse bleeding due to heparin
d. Tissue damage cannot activate KKK

D

10

Not a function of 5ht

a. Regulation of GI motility and peristalsis
b. Bronchodilation
c. Central chemical transmitter for tryptaminergic neurons of the brain
d. Precursor of melatonin

B

11

Incorrect match between the 5HT receptor antagonist / agonist drugs with their clinical use

a. 5HT3 Antagonist / ondansetron – nausea, vomiting
b. 5HT4 agonist / Cisapride – anxiety/depression
c. 5HT 1D agonist / Sumatripan – migraine
d. 5HT2A Antagonist / Ketaneserin – hypertension

B

12

Example of non-selective 5HT receptor antagonist:

a. Buspirone
b. Trazodone
c. Ergotamin
d. Ketanserin

C

13

The gastrointestinal bleeding from aspirin is considered:

a. side effect
b. extension effect
c. drug toxicity
d. medication error

A

14


8. Autacoids involved in inflammatory reaction, EXCEPT

a. Histamine
b. Bradykinin
c. Serotonin
d. Prostanoids
e. Angiotensin II

E

15

The following physiologic effects are mediated by histamine EXCEPT

a. Vasodilatation
b. Increased vascular permeability
c. Relaxation of intestinal smooth muscles
d. Stimulation of sensory nerve endings

C

16

H1 blockers (traditional / older antihistamines) have the following effects:

a. Promote sedation
b. Relieve allergic manifestations on the skin and mucous membrane
c. Emesis
d. All of the above
e. A and B only

D

17

Which of the following is least sedating

a. Loratadine
b. Chlorpenamine
c. Diphenhydramine
d. Clemastine

A

18

What are the therapeutic uses of the H1 blockers? ALL EXCEPT

a. As a sleeping aid
b. For countering motion sickness
c. To moisten the mouth and throat
d. To relieve itching and rashes in allergic disease

C

19

Body functions where 5-HT in involved

a. Fertility
b. Feeding
c. Sleeping
d. Mentation
e. All of the above

E

20

The enzyme responsible for converting tryptophan to serotonin belongs to what class

a. Lipoxygenase
b. Hydroxylase
c. Peroxidase
d. Transferase

B

21

Prostanoids have the following actions/clinical significance

a. Platelet function
b. Inflammatory reaction
c. Reproduction
d. A and B only
e. All of the above

E

22

Which of the following anti-inflammatory agents is unique that it binds to its receptor irreversibly?

a. Ibuprofen
b. Mefenamic acid
c. Acetaminophen
d. Aspirin

D

23

An example of lipoxygenase inhibitor is:

a. Celecoxib
b. Zileuton
c. Montelukast
d. Misoprostol

B

24

Histamine

a. has powerful effects on smooth and cardiac muscles
b. endothelial cells and nerves
c. more effect on guinea pigs than humans
d. gastric acid secretion
e. AOTA

E

25

Traditional antihistamines with sedative effect include

a. Diphenhydramine
b. Loratadine
c. Cetirizine
d. AOTA
e. A&C only

A

26

Actions mediated by H1 blocker but not through H1 receptor

a. Bronchia; and GI smooth muscle relaxation
b. Endothelial constriction resulting in increased muscular permeability
c. Dilation of vascular smooth muscle from NO from EDRF
d. sedative, antinausea effect
e. AOTA

D

27

Serotonin is found in:

a. Enterochromaffin cells, 90% of the body
b. Platelets which are able to concentrate the amine by means of active SERT
c. Nerve endings, particularly brain serotonergic neurons as transmitter.
d. AOTA
e. B&C only

D

28

5HT in brain serotonergic neurons are involved in

a. mood, depression, anxiety
b. sleep, apetite and vomiting
c. pain, temperature regulation, migraine
d. AOTA
e. A and C only

D

29

Selective serotonin include:

a. Sumatriptan, 5HT1A/1D antagonist, for migraines and cluster headaches
b. buspirone, 5HT1 agonist used as a widely accepted anxiolitic
c. Ondesterone, 5HT3 for chemotherapy antiemesis
d. AOTA
e. B&C only

B

30

Angiotensin II and III effects are reversed by

a. renin inhibitors of synthesis or release
b. angiotensin converting enzyme inhibitors
c. kininase II inhibitors
d. angiotensin receptor antagonist
e. AOTA

E