Samplex 2015 Set B Flashcards Preview

[Ther 201] E2 > Samplex 2015 Set B > Flashcards

Flashcards in Samplex 2015 Set B Deck (50)
Loading flashcards...
1

sympathetic activation will lead to the following action:

A. Pupil dilation
B. Bronchoconstriction
C. Bradycardia

A

2

Possible mechanisms of action of indirect adrenergic agonists

a. binds to adrenergic receptors
b. blocks MAO
c. enhances reuptake of NE from the synaptic cleft
d. enhances activity of COMT

B

3

Adrenergic Receptor predominantly found in the heart.

A. Alpha 1
B. Alpha 2
C. Beta 1
D. Beta 3

C

4

Adrenoreceptor coupled to Gq protein and especially found in smooth muscles.

A. Alpha 1
B. Alpha 2
C. Beta 1
D. Beta 2

A

5

True of the structure-activity relationship

A. Increase in alkyl substitution in the amino group, increase in Beta receptor activity
B. Decrease the substitution in the benzene ring, decrease in potency
C. substitution in the alpha-carbon prolongs drug activity
D. AOTA

D

6

Beta 2 adrenergic agonists are most useful with the condition:

A. Hypertension
B. Asthma
C. Heart Failure
D. Arrhythmia

B

7

Beta 1 receptor activation effects include

A. stimulation of renin release
B. skin vasodilation
C. insulin release
D. skeletal muscle tremor

A

8

Postsynaptic activation of Alpha 1 receptor will lead to:

A. Cutaneous vasodilation
B. Lipolysis
C. Nasal Decongestion
D. Uterine relaxation

C

9

Patient with septic shock was started on low dose of dopamine, what is an expected effect?

A. Vasoconstrict
B. Decrease cardiac output
C. Bradycardia
D. Increase renal blood flow

D

10

Alpha 2 agonist activation will most likely lead to:

A. vasoconstriction
B. bronchodilation
C. decrease in insulin and rennin release
D. AOTA

D

11

An adolescent brought to the ER presenting with aggressive behaviour, tremor, anxiety, paranoid state, hypertension, and tachycardia was diagnosed to have metamphetamine abuse. Which of the ff. is the action of amphetamine?

A. It binds directly to Alpha 1 and Beta 1 receptors
B. It displaces NE from vesicles
C. It enhances MAO activity
D. It promotes exocytotic release of NE

B

12

Alpha-1 blockers are beneficial in:

A. hypotension
B. asthma
C. urinary retention
D. nasal decongestion

C

13

Adverse effects of adrenoceptor blocker

A. bronchoconstriction – alpha blockade
B. increase intraocular pressure – beta blockade
C. hypertension
D. severe bradycardia

D

14

Reserpine action

A. direct agonist
B. inhibits VMAT
C. inhibits MAO
D. AOTA

B

15

The additional effect of some B-blockers like labetalol and pirdolol which can prevent untoward effects like asthma and bradycardia is due to:

A. partial agonist effect
B. potassium blockade
C. local anesthetic effect
D. AOTA

A

16

α1 = α2; β1 >> β2

A. Dobutamine
B. Epinephrine
C. Norepinephrine
D. Phenylephrine
E. Terbutalin

C

17

α1 = α2; β1 = β2

A. Dobutamine
B. Epinephrine
C. Norepinephrine
D. Phenylephrine
E. Terbutalin

B

18

β1 > β2 >>>> α

A. Dobutamine
B. Epinephrine
C. Norepinephrine
D. Phenylephrine
E. Terbutalin

E

19

β2 >> β1 >>>α

A. Dobutamine
B. Epinephrine
C. Norepinephrine
D. Phenylephrine
E. Terbutalin

A

20

Diarrhea in diabetics with autonomic neuropathy

A. Clonidine
B. Dobutamine
C. Epinephrine
D. Terbutalin

A

21

Preterm labor

A. Clonidine
B. Dobutamine
C. Epinephrine
D. Terbutalin

D

22

Anaphylactic shock

A. Clonidine
B. Dobutamine
C. Epinephrine
D. Terbutalin

C

23

A selective α1 antagonist

A. Atenolol
B. Esmolol
C. Phenoxybenzamine
D. Prazosin
E. Propranolol

D

24

Long-acting selective β-blocker

A. Atenolol
B. Esmolol
C. Phenoxybenzamine
D. Prazosin
E. Propranolol

A

25

Non-selective β-blocker

A. Atenolol
B. Esmolol
C. Phenoxybenzamine
D. Prazosin
E. Propranolol

E

26

An α-receptor irreversible antagonist

A. Atenolol
B. Esmolol
C. Phenoxybenzamine
D. Prazosin
E. Propranolol

C

27

β-blocker with the shortest half-life

A. Atenolol
B. Esmolol
C. Phenoxybenzamine
D. Prazosin
E. Propranolol

B

28

Sympathetic activation will lead to which of the following physiologic function/s

A. Pupillary constriction
B. Bronchodilation
C. Gluconeogenesis
D. Micturition
E. Lipogenesis

B

29

Activation of which of the following adrenoreceptors inhibits adenyl cyclase causing a decrease in cAMP

A. Alpha-1
B. Alpha-2
C. Beta-1
D. Beta-3
E. D-1

B

30

Which of the following is TRUE about structure-activity relationship of direct adrenergic agonists?

a. increasing the size of alkyl substituents on the amino group tends to increase alpha-receptor activity
b. decreased substitution in the benzene ring reduces bioavailability
c. decreased substitution in the benzene increases potency
d. substitution in the alpha-carbon prolongs drug action
e. all of the above

D