Cystic Fibrosis and Tuberculosis Flashcards Preview

D&T 3 test 2 > Cystic Fibrosis and Tuberculosis > Flashcards

Flashcards in Cystic Fibrosis and Tuberculosis Deck (39):
1

What is the most common lethal genetic disease in Caucasians

Cystic fibrosis

2

how is cystic fibrosis inherited

autosomal recessive

3

what chromosome is cystic fibrosis on

chromosome 7

4

what is the gene product for cystic fibrosis?

CF transmembrane conductance regulator ( CFTR)

5

How do 70% of mutations occur in cystic fibrosis

3 nucleotide deletion
- delete a single amino acid
- delta F508

6

What are the major organs affected in cystic fibrosis

lung and exocrine glands ( pancreas and small intestines)

7

what are lung and upper respiratory findings in cystic fibrosis

- chronic cough with sputum secretion
- chronic wheezing
-chronic pansinusitis
- nalal polyposis
-strep. pneumo as an infant

8

what are GI problems and hormonla probelms with cystic fibrosis

- meconium ileus (MI) intestinal blockage
- pancreatic insufficiency
- liver disease
- delayed puberty

9

what is seen in X-ray of cystic fibrosis

accumulation of neutrophils

10

what is the most common bacteria to cause cystic fibrosis

P. aeruginosa

11

Is p. aeruginosa gram positive or negative

negative

12

what is the shape of p. aeruginosa

rod shape

13

What does p. aeruginosa produce

"grape-like odor"
produces biofilm (polysacharide)

14

Alginate produces what

mucoidy

15

what is required for alginate to replicate

lot of cellular energy

16

what encloses bacteria in biofilm? Where is biofilm found?

exopolysaccharide matrix enclosed bacterial COMMUNITY, different from bacteria in suspension
-biofilms is found every UBIQUITOUS

17

what are clinical manifestations of CF (3)

1. localized lung infection: excessive neutrophil infiltration
2. infection around bronchi and bronchioles
3. malnutrition

18

What is used to treat cystic fibrosis? how is the pseudo treated

- inhaled tobramycin and oral azithromycin
- combination therapy for pseudo: penicillin, ticarcillin or piperacillin, plus aminoglycosdie ( gentamicin or amikacin)

19

is Psuedo resistant to many durgs

YES

20

What is the second and first most common infectious cause of death in adults worldwide

- Tuberculosos 2
- HIV 1

21

where does mycoplasma tuberculosis reside in body

macrophages and monocytes

22

Where does secondary TB usually occur in lung

apex of lung

23

tuberculosis describe the bacteria

- gram + like cell wall
- aerobic rod `

24

what is tuberculosis bacteria resistant to

drying
chemical
germicides

25

what is located in cell of tuberculosis

mycolic acid waxes

26

how do you stain for tuberculosis

acid fast

27

how fast does tuberculosis grow

slow

28

How can tuberculosis live a macrophage

- prevents phagocytic/lysosome vesicle fursion
- LLO homologue (hemolysin)

- prevents acidification of phagosome
- produce NH4

29

What causes lung damage by tubercuosis

TNF alpha provoked by cell wall components

30

what role does mycolic acids have in tuberculosis

stimulates immune response

31

What medium does tuberculosis grow on

Lowenstein-Jenson
Middlebrook

32

What is caseous granuloma

- central core-multinucleated giant cells ( fused macrophages)

- epithelioid cell- large macrophages

- CD4 positive T cells

33

What is ghon comples

hilar lymphadenopathy
Langhan's cells

34

what is Miliary TB

white nodules

35

relate TB and AIDS

TB kills more rapidly in AIDS

36

Aids and TB patients are more likely to have what clinical symptoms

- extrapulmonary disease
- lymph nodes
- genitourinary
- CNS

37

AIDS and TB are susceptible to what infection

MAI

38

What test is used to detect TB

PPD

39

Who may not show a positive PPD test even though they have TB

AIDS
cross- reactive to other mycobacteria
BCG