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Flashcards in Saroj 2 Deck (56):
1

how do you diagnose sarcoidosis

diagnosis of exclusion

2

Sarcoidosis occurs more commonly in who

women
african american
southeast US

3

what are immunologic and genetic abnormalitlies of sarcoidosis

-CD4
IL2
IL8
TNF
macrophage inflammatory protein
increased

4

histo for sarcoidosis? types of cells seen?

noncaseating granulomas
- epithelioid cells
- langhans
-Schaumann bodies
- asteroid bodies

5

The granulomas in sarcoidosis may be replaced by

firbrous scars

6

how are the lungs impacted in Sarcoidosis?

-bilateral hilar lymphadenopathy or lung involvment

7

granulomas are in close proximity to what in lungs in sarcoidosis

lymphatics, bronchi, and blood vessels

8

lesions in lung in Sarcoidosis tend to produce what

interstitial fibrosis

9

what yields to a high diagnostic yield for sarcoidosis

bronchoscopic biopsies

10

what lymph nodes are involved with sarcoidosis? what happens to them

hilar and mediastinal lymph nodes
- calcified

11

how is the liver impacted in sarcoidosis

granulomas in portal tarcts

12

which part of the bodies bone marrow is impacted by sarcoidosis

hands and feet

13

how is eye impacted by sarcoidosis

Mikulicz syndrome
Iritis and Dacroadenitis

14

Dacroadenitis

lacrimal gland inflammation

15

Mikulicz syndrome

lacrimal gland involvement + bilateral parotid, submaxillary and sublingual glands

16

what is chest x-ray sarcoidosis

bilateral hilar lymphadenopathy

17

clinical symptoms for sarcoidosis

dyspnea
cough
chest pain
maybe hemotpysis

18

what is prognosis for sarcoidosis

2/3 recover

19

who has the best prognosis for sarcoidosis

patients with hilar lymphadenopathy only

20

who has fewer remission

patients with pulmonary disease only

21

what is hypersensitivity pneumonitis

immunologically-mediated disorders

22

etiology for hypersensitivity pneumonitis

prolonged exposure to inhaled organic dusts and occupational antigens

23

What type of hypersensitivity reactions are seen in hypersensitivity pneumonitis

Type III - immune complex
Type IV - delayed type

24

hypersensitivity pneumonitis: farmers lung

inhaled spores of thermophilic actinomycetes

25

hypersensitivity pneumonitis: pigeon breeder's lung

inhaled proteins from feathers or excretion

26

hypersensitivity pneumonitis: humidifier lung

inhaled thermophilic bacteria from heated water reservoirs

27

hypersensitivity pneumonitis what is on histo slide

1. chronic interstitial pneumonitis with lymphocytes, plasma cells, macrophages
2. noncaseating granulomas
3. interstitial fibrosis and HONEYCOMBING

28

when do acute attacks occur for hypersensitivity pneumonitis? what is a clinical symptoms

in previously sensitized patient
-fever

29

when do symptoms begin after re-exposure

4-6 hours

30

clinical symptoms for chronic hypersensitivity pneumonitis? how does this impact lung

dyspnea CYANOSIS
decrease lung compliance and lung capacity

31

Pulmonary Eosinophilia: acute: most likely etiology

hypersensitivity response to inhaled antigen ( not drugs or food)

32

clinical features for Pulmonary Eosinophilia: acute:

rapid fever
hypoxemia
respiratory failure

33

Another name for Pulmonary Eosinophilia: simple pulmonary eosinophilia

Loeffler's syndrome

34

what is the most likely etiology for Loeffler's syndrome

hypersensitivity to food or drugs (sulfa drugs)

35

X- ray for Pulmonary Eosinophilia: simple pulmonary eosinophilia

prominent irregular lung densitites

36

what is in the blood for leoffler's syndrome

blood eosinophilia

37

Pulmonary Eosinophilia: secondary pulmonary eosinophilia: seen in what type of infections

parasitic
bacterial
fungal

38

Pulmonary Eosinophilia: secondary pulmonary eosinophilia is associated with what

asthma
allergic bronchopulomary aspergillosis

39

Pulmonary Eosinophilia: chronic eosinophilic pneumonia: associated with?

autoimmune disease: rheumatoid arthritis

40

what is the histo for Pulmonary Eosinophilia: chronic pulmonary eosinophilia

lymphocytic and eosinophilic

41

clinical feature for Pulmonary Eosinophilia: chronic pulmonary eosinophilia

high fever

42

Desquamative interstitial pneumonitis is related to

smoking interstitial disease

43

What is morphology for Desquamative interstitial pneumonitis

alveoli filled with numerous pigment-laden macrophages ( "smokers" macrophage)

44

when do Desquamative interstitial pneumonitis symptoms begin

4 or 5 decade

45

gender Desquamative interstitial pneumonitis

male

46

treatment Desquamative interstitial pneumonitis

steroid

47

what is histo for respiratory bronchiolitis - associated interstitial lung disease

respiratory bronchioles
alveoli with 'smokers' macrophages

48

onset and gender respiratory bronchiolitis - associated interstitial lung disease

men
4 and 5 decade

49

Pulmonary alveolar proteinosis: acquired PAP due to

granulocyte macrophage colony stimulating factor (GM-CSF) antibodies
- causes impaired surfactant clearance

50

Pulmonary alveolar proteinosis: secondary PAP etiologies include

silicosis
immunodeficiency syndromes

51

morphology of pulmonary alveolar proteinosis

- marked increase in lung size and weight
- PAS +
- cholesterol clefts
- minimal inflammation

52

X-ray for Pulmonary alveolar proteinosis

- consolidation

53

insidious onset Pulmonary alveolar proteinosis

dyspnea
productive cough with gelatinous material

54

what is mortality in congenital PAP

fatal

55

what is used to remove alveolar precipitate

bronchoalveolar lavage

56

are schuamann and asteroid bodies pathogenic for sarcoidosis

no