Saroj 2

Question 1

how do you diagnose sarcoidosis

Answer 1

diagnosis of exclusion

Question 2

Sarcoidosis occurs more commonly in who

Answer 2

women
african american
southeast US

Question 3

what are immunologic and genetic abnormalitlies of sarcoidosis

Answer 3

-CD4
 IL2
IL8
 TNF
macrophage inflammatory protein
  increased

Question 4

histo for sarcoidosis? types of cells seen?

Answer 4

noncaseating granulomas

• epithelioid cells
• langhans
• Schaumann bodies
• asteroid bodies

Question 5

The granulomas in sarcoidosis may be replaced by

Answer 5

firbrous scars

Question 6

how are the lungs impacted in Sarcoidosis?

Answer 6

-bilateral hilar lymphadenopathy or lung involvment

Question 7

granulomas are in close proximity to what in lungs in sarcoidosis

Answer 7

lymphatics, bronchi, and blood vessels

Question 8

lesions in lung in Sarcoidosis tend to produce what

Answer 8

interstitial fibrosis

Question 9

what yields to a high diagnostic yield for sarcoidosis

Answer 9

bronchoscopic biopsies

Question 10

what lymph nodes are involved with sarcoidosis? what happens to them

Answer 10

hilar and mediastinal lymph nodes

- calcified

Question 11

how is the liver impacted in sarcoidosis

Answer 11

granulomas in portal tarcts

Question 12

which part of the bodies bone marrow is impacted by sarcoidosis

Answer 12

hands and feet

Question 13

how is eye impacted by sarcoidosis

Answer 13

Mikulicz syndrome

Iritis and Dacroadenitis

Question 14

Dacroadenitis

Answer 14

lacrimal gland inflammation

Question 15

Mikulicz syndrome

Answer 15

lacrimal gland involvement + bilateral parotid, submaxillary and sublingual glands

Question 16

what is chest x-ray sarcoidosis

Answer 16

bilateral hilar lymphadenopathy

Question 17

clinical symptoms for sarcoidosis

Answer 17

dyspnea
cough
chest pain
maybe hemotpysis

Question 18

what is prognosis for sarcoidosis

Answer 18

2/3 recover

Question 19

who has the best prognosis for sarcoidosis

Answer 19

patients with hilar lymphadenopathy only

Question 20

who has fewer remission

Answer 20

patients with pulmonary disease only

Question 21

what is hypersensitivity pneumonitis

Answer 21

immunologically-mediated disorders

Question 22

etiology for hypersensitivity pneumonitis

Answer 22

prolonged exposure to inhaled organic dusts and occupational antigens

Question 23

What type of hypersensitivity reactions are seen in hypersensitivity pneumonitis

Answer 23

Type III - immune complex

Type IV - delayed type

Question 24

hypersensitivity pneumonitis: farmers lung

Answer 24

inhaled spores of thermophilic actinomycetes

Question 25

hypersensitivity pneumonitis: pigeon breeder's lung

Answer 25

inhaled proteins from feathers or excretion

Question 26

hypersensitivity pneumonitis: humidifier lung

Answer 26

inhaled thermophilic bacteria from heated water reservoirs

Question 27

hypersensitivity pneumonitis what is on histo slide

Answer 27

1. chronic interstitial pneumonitis with lymphocytes, plasma cells, macrophages 2. noncaseating granulomas 3. interstitial fibrosis and HONEYCOMBING

Question 28

when do acute attacks occur for hypersensitivity pneumonitis? what is a clinical symptoms

Answer 28

in previously sensitized patient | -fever

Question 29

when do symptoms begin after re-exposure

Answer 29

4-6 hours

Question 30

clinical symptoms for chronic hypersensitivity pneumonitis? how does this impact lung

Answer 30

dyspnea CYANOSIS | decrease lung compliance and lung capacity

Question 31

Pulmonary Eosinophilia: acute: most likely etiology

Answer 31

hypersensitivity response to inhaled antigen ( not drugs or food)

Question 32

clinical features for Pulmonary Eosinophilia: acute:

Answer 32

rapid fever hypoxemia respiratory failure

Question 33

Another name for Pulmonary Eosinophilia: simple pulmonary eosinophilia

Answer 33

Loeffler's syndrome

Question 34

what is the most likely etiology for Loeffler's syndrome

Answer 34

hypersensitivity to food or drugs (sulfa drugs)

Question 35

X- ray for Pulmonary Eosinophilia: simple pulmonary eosinophilia

Answer 35

prominent irregular lung densitites

Question 36

what is in the blood for leoffler's syndrome

Answer 36

blood eosinophilia

Question 37

Pulmonary Eosinophilia: secondary pulmonary eosinophilia: seen in what type of infections

Answer 37

parasitic bacterial fungal

Question 38

Pulmonary Eosinophilia: secondary pulmonary eosinophilia is associated with what

Answer 38

asthma | allergic bronchopulomary aspergillosis

Question 39

Pulmonary Eosinophilia: chronic eosinophilic pneumonia: associated with?

Answer 39

autoimmune disease: rheumatoid arthritis

Question 40

what is the histo for Pulmonary Eosinophilia: chronic pulmonary eosinophilia

Answer 40

lymphocytic and eosinophilic

Question 41

clinical feature for Pulmonary Eosinophilia: chronic pulmonary eosinophilia

Answer 41

high fever

Question 42

Desquamative interstitial pneumonitis is related to

Answer 42

smoking interstitial disease

Question 43

What is morphology for Desquamative interstitial pneumonitis

Answer 43

alveoli filled with numerous pigment-laden macrophages ( "smokers" macrophage)

Question 44

when do Desquamative interstitial pneumonitis symptoms begin

Answer 44

4 or 5 decade

Question 45

gender Desquamative interstitial pneumonitis

Answer 45

male

Question 46

treatment Desquamative interstitial pneumonitis

Answer 46

steroid

Question 47

what is histo for respiratory bronchiolitis - associated interstitial lung disease

Answer 47

respiratory bronchioles | alveoli with 'smokers' macrophages

Question 48

onset and gender respiratory bronchiolitis - associated interstitial lung disease

Answer 48

men | 4 and 5 decade

Question 49

Pulmonary alveolar proteinosis: acquired PAP due to

Answer 49

granulocyte macrophage colony stimulating factor (GM-CSF) antibodies - causes impaired surfactant clearance

Question 50

Pulmonary alveolar proteinosis: secondary PAP etiologies include

Answer 50

silicosis | immunodeficiency syndromes

Question 51

morphology of pulmonary alveolar proteinosis

Answer 51

- marked increase in lung size and weight - PAS + - cholesterol clefts - minimal inflammation

Question 52

X-ray for Pulmonary alveolar proteinosis

Answer 52

- consolidation

Question 53

insidious onset Pulmonary alveolar proteinosis

Answer 53

dyspnea | productive cough with gelatinous material

Question 54

what is mortality in congenital PAP

Answer 54

fatal

Question 55

what is used to remove alveolar precipitate

Answer 55

bronchoalveolar lavage

Question 56

are schuamann and asteroid bodies pathogenic for sarcoidosis

Answer 56

no