Lung tumors and Pleura - Saroj Flashcards Preview

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Flashcards in Lung tumors and Pleura - Saroj Deck (58):
1

what is the most common cause of cancer mortality worldwide

lung tumors

2

what are 3 things that can cause lung cancer

tobacco smoking
industrial hazards
air pollutoin

3

What is the most common cancer for malignancy for asbestosis

bronchogenic carcinoma or lung cancer

4

Female, asian, 40 yr old, nonsmoker, with lung history will likely show what mutation? with adenocarcinomas

EGFR

5

what are 4 precursor lesions for lung tumors

1. squamous dysplasia/ Carcinoma in situ
2. atypical adenomatous hyperplasia
3. adenocarcinoma in-situ
4. neuroendocrine cell hyperplasia

6

what type of lung cancer is a candidate for surgery

non-small cell carcinoma

7

how do you treat small cell carcinoma

chemotherapy

8

Name 2 types of non-small cell carcinoma

1. squamous cell carcinoma
2. adenocarcinoma

9

which lung cancer is almost always metastatic

small cell

10

what type of lung cancer is associated with smoking

squamous

11

location of squamous cell carcinoma

centrally located

12

mutation related to squamous cell carcinoma

p53 mutation

13

what would be a blood value for squamous cell carcinoma

hypercalcemia

14

histo, well-differentiated squamous cell carcinoma

keratinization/squamous pearls
intercellular bridges

15

histo, poorly differentiated squamous cell carcinoma

increased mitotic activity

16

patient smokes, central necrosis, increase Ca levels, biopsy shows squamous pearl, intercellular bridging. would you perform surgery?

yes

17

squamous cell amplifies what gene

FGFR1

18

what is most common lung cancer in women

adenocarcinoma

19

location of adenocarcinoma in lung

peripheral bronchioloalveolar regions

20

does adenocarcinoma in-situ invade

no invasion, lines alveolar

21

Another name for adenocarcinoma in-situ

Bronchioloaleolar carcinoma BAC

22

adenocarcinoma is positive for what in immunohistochemical stain

TTF-1 positive

23

histo for adenocarcinoma in-situ

lepidic growth pattern

24

how can adenocarcinoma in-situ present clinically sometimes

pneumonia-like

25

what type of cells are in adenocarcinoma in-situ mucinous

tall columnar cells with intracytoplasmic mucin

26

what type of cells are in adenocarcinoma in-situ non-mucinous

cuboidal cells

27

which type of adenocarcinoma in situ spreads aerogenously with satellite lesions

mucinous

28

what type of adenocarcinoma in situ has better prognosis

non-mucinous

29

Adenocarcinoma, NONSMOKER , female will have a gain of function mutation in what tyrsosine kinase mutation

EGFR

30

Adenocarcinoma, SMOKER female will have a gain of function mutation in what non tyrsosine kinase mutation

KRAS

31

what type of tumor is neuroendocrine proliferations and tumors

non-small

32

what are important features for neuroendocrine proliferations and tumors

mitotic figures
necrosis

33

histo for small cell carcinoma

- Azzopardi effect: basophillic staining
- high mitotic count
- cell necrosis
- nuclear molding
- ill defined cells

34

what do granules look like on EM for small cell carcinoma

dense core

35

histo for carcinoid tumor

- organoid pattern
- small rounded uniform nuclei
- moderate cytoplasm

36

what makes up a Hamartoma

stromal and epithelial components
-cartilage and columnar epithelium
-coin lesion

37

who gets lymphanioleiomyomatosis

young women of childbearing age

38

what is lymphanioleiomyomatosis

proliferation of perivascular epithelioid cells

39

what is lymphanioleiomyomatosis positive for

melanocytic marker
smooth muscle marker
suppressor TSC 2

40

Inflammatory myofibroblastic tumor

inflammatory pseudotmor/plasma cell granuloma

41

who gets Inflammatory myofibroblastic tumor

children and young adults

42

what is the common metastasis place for lung cancer

adrenal

43

what are 3 lung cancer syndromes

Lambert-Eaton myasthenic syndrome
Superior vena cava syndrome
Horner's syndrome

44

what is Lambert-Eaton myasthenic syndrome

weakness of proximal legs and arms

45

what can Superior vena cava syndrome cause

circulatory compromise

46

name primary tumor pleura

solitary fibrous tumor

47

solitary fibrous tumor invlves what pleura

viscerla

48

solitary fibrous tumor benign or malignant

benign

49

Gross solitary fibrous tumor

dense fibrous tissue
- sometimes cysts

50

microscopic solitary fibrous tumor

whorls of reticulin and collagen
interspersed spindle cells

51

solitary fibrous tumor stains for

CD34 positive
Keratine negative

52

solitary fibrous tumor relationship with asbestosi

no

53

clinical presentation for malignant mesothelioma

unilateral chest pain
flu-like

54

what is malignant mesothelioma assoicated and not associated with

associated with asbestois
not with smoking

55

histo for malignant mesothelioma

gra-white nodules

56

histo subtypes for malignant mesothelioma

- epitheliod
- sarcomatoid

57

malignant mesothelioma , IHC stains for

Calretinin
WT-1
CK5/6
D2-40

58

malignant mesothelioma Em shows

long microvilli