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D&T 3 test 2 > Lung tumors and Pleura - Saroj > Flashcards

Lung tumors and Pleura - Saroj Flashcards

(58 cards)

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1
Q

what is the most common cause of cancer mortality worldwide

A

lung tumors

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2
Q

what are 3 things that can cause lung cancer

A

tobacco smoking
industrial hazards
air pollutoin

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3
Q

What is the most common cancer for malignancy for asbestosis

A

bronchogenic carcinoma or lung cancer

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4
Q

Female, asian, 40 yr old, nonsmoker, with lung history will likely show what mutation? with adenocarcinomas

A

EGFR

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5
Q

what are 4 precursor lesions for lung tumors

A
  1. squamous dysplasia/ Carcinoma in situ
  2. atypical adenomatous hyperplasia
  3. adenocarcinoma in-situ
  4. neuroendocrine cell hyperplasia
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6
Q

what type of lung cancer is a candidate for surgery

A

non-small cell carcinoma

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7
Q

how do you treat small cell carcinoma

A

chemotherapy

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8
Q

Name 2 types of non-small cell carcinoma

A
  1. squamous cell carcinoma

2. adenocarcinoma

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9
Q

which lung cancer is almost always metastatic

A

small cell

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10
Q

what type of lung cancer is associated with smoking

A

squamous

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11
Q

location of squamous cell carcinoma

A

centrally located

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12
Q

mutation related to squamous cell carcinoma

A

p53 mutation

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13
Q

what would be a blood value for squamous cell carcinoma

A

hypercalcemia

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14
Q

histo, well-differentiated squamous cell carcinoma

A

keratinization/squamous pearls

intercellular bridges

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15
Q

histo, poorly differentiated squamous cell carcinoma

A

increased mitotic activity

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16
Q

patient smokes, central necrosis, increase Ca levels, biopsy shows squamous pearl, intercellular bridging. would you perform surgery?

A

yes

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17
Q

squamous cell amplifies what gene

A

FGFR1

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18
Q

what is most common lung cancer in women

A

adenocarcinoma

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19
Q

location of adenocarcinoma in lung

A

peripheral bronchioloalveolar regions

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20
Q

does adenocarcinoma in-situ invade

A

no invasion, lines alveolar

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21
Q

Another name for adenocarcinoma in-situ

A

Bronchioloaleolar carcinoma BAC

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22
Q

adenocarcinoma is positive for what in immunohistochemical stain

A

TTF-1 positive

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23
Q

histo for adenocarcinoma in-situ

A

lepidic growth pattern

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24
Q

how can adenocarcinoma in-situ present clinically sometimes

Study These Flashcards
A

pneumonia-like

25
what type of cells are in adenocarcinoma in-situ mucinous
tall columnar cells with intracytoplasmic mucin
26
what type of cells are in adenocarcinoma in-situ non-mucinous
cuboidal cells
27
which type of adenocarcinoma in situ spreads aerogenously with satellite lesions
mucinous
28
what type of adenocarcinoma in situ has better prognosis
non-mucinous
29
Adenocarcinoma, NONSMOKER , female will have a gain of function mutation in what tyrsosine kinase mutation
EGFR
30
Adenocarcinoma, SMOKER female will have a gain of function mutation in what non tyrsosine kinase mutation
KRAS
31
what type of tumor is neuroendocrine proliferations and tumors
non-small
32
what are important features for neuroendocrine proliferations and tumors
mitotic figures | necrosis
33
histo for small cell carcinoma
- Azzopardi effect: basophillic staining - high mitotic count - cell necrosis - nuclear molding - ill defined cells
34
what do granules look like on EM for small cell carcinoma
dense core
35
histo for carcinoid tumor
- organoid pattern - small rounded uniform nuclei - moderate cytoplasm
36
what makes up a Hamartoma
stromal and epithelial components - cartilage and columnar epithelium - coin lesion
37
who gets lymphanioleiomyomatosis
young women of childbearing age
38
what is lymphanioleiomyomatosis
proliferation of perivascular epithelioid cells
39
what is lymphanioleiomyomatosis positive for
melanocytic marker smooth muscle marker suppressor TSC 2
40
Inflammatory myofibroblastic tumor
inflammatory pseudotmor/plasma cell granuloma
41
who gets Inflammatory myofibroblastic tumor
children and young adults
42
what is the common metastasis place for lung cancer
adrenal
43
what are 3 lung cancer syndromes
Lambert-Eaton myasthenic syndrome Superior vena cava syndrome Horner's syndrome
44
what is Lambert-Eaton myasthenic syndrome
weakness of proximal legs and arms
45
what can Superior vena cava syndrome cause
circulatory compromise
46
name primary tumor pleura
solitary fibrous tumor
47
solitary fibrous tumor invlves what pleura
viscerla
48
solitary fibrous tumor benign or malignant
benign
49
Gross solitary fibrous tumor
dense fibrous tissue | - sometimes cysts
50
microscopic solitary fibrous tumor
whorls of reticulin and collagen | interspersed spindle cells
51
solitary fibrous tumor stains for
CD34 positive | Keratine negative
52
solitary fibrous tumor relationship with asbestosi
no
53
clinical presentation for malignant mesothelioma
unilateral chest pain | flu-like
54
what is malignant mesothelioma assoicated and not associated with
associated with asbestois | not with smoking
55
histo for malignant mesothelioma
gra-white nodules
56
histo subtypes for malignant mesothelioma
- epitheliod | - sarcomatoid
57
malignant mesothelioma , IHC stains for
Calretinin WT-1 CK5/6 D2-40
58
malignant mesothelioma Em shows
long microvilli

D&T 3 test 2 (14 decks)

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