Fenger

Question 1

What is usually not involved with parainfluenza virus and influenza virus

Answer 1

viremia

Question 2

how long is incubation period for respiratory viruses

Answer 2

short

1-3 days

Question 3

What if the virus causes a viremia, how long is incubation period

Answer 3

longer

weeks to weeks

Question 4

What is the genomic make up for paramyxovirdiae

Answer 4

SS RNA
negative polarity
nonsegmeted

Question 5

What structures does paramyxovirdiae have

Answer 5

Helical nucleocapsid
RNA dependent RNA polymerase
envelope
6 structural proteins

Question 6

Name some glycoprotiens in paramyxovirdiae

Answer 6

Hemagglutinin (H) and Neruminadase (N)

Question 7

What are the 3 primary genera for paramyxovirdiae

Answer 7

1. paramyxovirus
2. morbillivirus
3. pneumovirus

Question 8

How do the genera of paramyxovirdiae differe

Answer 8

differe in envelope glycoproteins

Question 9

function of H glycoprotein

Answer 9

attachment of virus to receptors on cell surface

Question 10

function of F glycoprotein

Answer 10

mediates fusion between viral envelope and outer cell membrane

Question 11

what must happen to F glycoprotein in order for it to work

Answer 11

• proteolytically cleaved on viral envelope surface

Question 12

F glycoprotein is similar to what

Answer 12

H glycoprotein of influenza virus

Question 13

Where does Paramyxoviridae virus repliacate

Answer 13

cytoplasm

Question 14

Paramyxovirus genus: type 1 symptoms

Answer 14

croup 
acute respiratory disease
pneumonitis of newborns 
colds in adults
coryza
pharyngitis
bronchitis
children - bronchiolitis

Question 15

Paramyxovirus genus: type 2 symptoms

Answer 15

coup

laryngotracheobronchitis

Question 16

Paramyxovirus genus: type 3 and 4 symptoms

Answer 16

acute respiratory disease
bronchitis
pneumonia

Question 17

Paramyxovirus genus has what disease

Answer 17

measles ( roseola)

Question 18

what is under pneumovirus genus

Answer 18

RSV

Question 19

what is the virulence factor for RSV

Answer 19

F glycoprotein

Question 20

clinical symptoms of RSV

Answer 20

bronchiolitis and pneumonia in infants

Question 21

what is the immune defense for RSV? what is not a good immune response

Answer 21

IgA

- maternal antibody IgG does not protect, may actually enhance severity

Question 22

What do you give to babies at risk for RSV

Answer 22

• Palivizumab

- IV prophylaxis

Question 23

which picornaviridae virus is acid stable and which ones are not

Answer 23

• enterovrises: acid stable

- rhinovirus is not

Question 24

Enterovirus is commonly seen in who

Answer 24

young individuals

immunocompromised

Question 25

How are HSV-1 gingtivostomatitis lesions seen

Answer 25

throughout oral cavity

Question 26

symptoms of Coxsackievirus group A

Answer 26

- hand, foot, mouth - cold virus - aseptic meningitis

Question 27

how many types of Coxsackie group B are there

Answer 27

6

Question 28

As in the case with other coxsackie viruses, the serotypes that cause coxsackie group B begin with?

Answer 28

respiratory infection

Question 29

clinical manifestation for Coxsackie group B

Answer 29

COLDS | summer grippe

Question 30

What are clinical features of Echovirus

Answer 30

- summer aseptic meningitis | - febrile illnes with rash ( young people)

Question 31

type D68 of new enteroviruses causes what? who is it seen in

Answer 31

respiratory illness | - more severe in children and asthmatics

Question 32

what is rhinovirus hard to distinguish from

Answer 32

H1N1

Question 33

what is the viral structure of Coronaviridae

Answer 33

- helical nucleocapsid | - positivve RNA

Question 34

Coronaviridae: coronavirus most common assoicated

Answer 34

SARS - group 2

Question 35

clinical feature of coronavirus? when does this usually occur

Answer 35

infectious bronchitis in adults winter or early spring - cold symptoms

Question 36

symptoms of SARS

Answer 36

high fever cough SOB

Question 37

what does SARS bind

Answer 37

1. cell receptors | 2. ACE 2 on epithelial cells

Question 38

What types of adenovirus is associated with military recruits

Answer 38

4,7,21 | 8

Question 39

Adenovirus has what 2 components

Answer 39

240 hexons | 12 pentons

Question 40

what do hexons connect?

Answer 40

contact with 6 neighboring capsomers | - each has small hole in the center

Question 41

Location of pentons? what do pentons connect

Answer 41

- vertices of icosahedron - contact with 5 neighboring capsomers - each has small hole in the center

Question 42

What does penton consist of

Answer 42

base fiber knob at distal end of fiber

Question 43

where does adenovirus replicate

Answer 43

host cell nucleus

Question 44

adenovirus produces what type of infection in tonsil, adenoids and other lymph organs in children

Answer 44

latent

Question 45

for adenovirus replication what early proteins are enzymes involved with DNA synthesis

Answer 45

thymidine kinase | DNA polymerase

Question 46

where does replication and viral assembly occur for adenovirus

Answer 46

nucleus | -grapelike cluster of virus particles

Question 47

What are the two important adenovirus types

Answer 47

4 and 7

Question 48

adenoviurs Type 7 and 3 have what clinical feature

Answer 48

pneumonia in children

Question 49

Adenoviurs types 8,7,19 have what clinical features

Answer 49

keratoconjunctivitis | shipyard conjunctivitis

Question 50

what type of vaccine is used for what serotype for adenovirus

Answer 50

live oral vaccine for type 4 and 7

Question 51

how does an oral, live-attenuated vaccine prevent respiratory disease

Answer 51

- increase IgG | - IgG indirectly impacts respiratory