Fenger Flashcards Preview

D&T 3 test 2 > Fenger > Flashcards

Flashcards in Fenger Deck (51):
1

What is usually not involved with parainfluenza virus and influenza virus

viremia

2

how long is incubation period for respiratory viruses

short
1-3 days

3

What if the virus causes a viremia, how long is incubation period

longer
weeks to weeks

4

What is the genomic make up for paramyxovirdiae

SS RNA
negative polarity
nonsegmeted

5

What structures does paramyxovirdiae have

Helical nucleocapsid
RNA dependent RNA polymerase
envelope
6 structural proteins

6

Name some glycoprotiens in paramyxovirdiae

Hemagglutinin (H) and Neruminadase (N)

7

What are the 3 primary genera for paramyxovirdiae

1. paramyxovirus
2. morbillivirus
3. pneumovirus

8

How do the genera of paramyxovirdiae differe

differe in envelope glycoproteins

9

function of H glycoprotein

attachment of virus to receptors on cell surface

10

function of F glycoprotein

mediates fusion between viral envelope and outer cell membrane

11

what must happen to F glycoprotein in order for it to work

- proteolytically cleaved on viral envelope surface

12

F glycoprotein is similar to what

H glycoprotein of influenza virus

13

Where does Paramyxoviridae virus repliacate

cytoplasm

14

Paramyxovirus genus: type 1 symptoms

croup
acute respiratory disease
pneumonitis of newborns
colds in adults
coryza
pharyngitis
bronchitis
children - bronchiolitis

15

Paramyxovirus genus: type 2 symptoms

coup
laryngotracheobronchitis

16

Paramyxovirus genus: type 3 and 4 symptoms

acute respiratory disease
bronchitis
pneumonia

17

Paramyxovirus genus has what disease

measles ( roseola)

18

what is under pneumovirus genus

RSV

19

what is the virulence factor for RSV

F glycoprotein

20

clinical symptoms of RSV

bronchiolitis and pneumonia in infants

21

what is the immune defense for RSV? what is not a good immune response

IgA
- maternal antibody IgG does not protect, may actually enhance severity

22

What do you give to babies at risk for RSV

- Palivizumab
- IV prophylaxis

23

which picornaviridae virus is acid stable and which ones are not

- enterovrises: acid stable
- rhinovirus is not

24

Enterovirus is commonly seen in who

young individuals
immunocompromised

25

How are HSV-1 gingtivostomatitis lesions seen

throughout oral cavity

26

symptoms of Coxsackievirus group A

- hand, foot, mouth
- cold virus
- aseptic meningitis

27

how many types of Coxsackie group B are there

6

28

As in the case with other coxsackie viruses, the serotypes that cause coxsackie group B begin with?

respiratory infection

29

clinical manifestation for Coxsackie group B

COLDS
summer grippe

30

What are clinical features of Echovirus

-summer aseptic meningitis
- febrile illnes with rash ( young people)

31

type D68 of new enteroviruses causes what? who is it seen in

respiratory illness
- more severe in children and asthmatics

32

what is rhinovirus hard to distinguish from

H1N1

33

what is the viral structure of Coronaviridae

- helical nucleocapsid
- positivve RNA

34

Coronaviridae: coronavirus most common assoicated

SARS - group 2

35

clinical feature of coronavirus? when does this usually occur

infectious bronchitis in adults
winter or early spring

- cold symptoms

36

symptoms of SARS

high fever
cough
SOB

37

what does SARS bind

1. cell receptors
2. ACE 2 on epithelial cells

38

What types of adenovirus is associated with military recruits

4,7,21
8

39

Adenovirus has what 2 components

240 hexons
12 pentons

40

what do hexons connect?

contact with 6 neighboring capsomers
- each has small hole in the center

41

Location of pentons? what do pentons connect

-vertices of icosahedron
- contact with 5 neighboring capsomers
- each has small hole in the center

42

What does penton consist of

base
fiber
knob at distal end of fiber

43

where does adenovirus replicate

host cell nucleus

44

adenovirus produces what type of infection in tonsil, adenoids and other lymph organs in children

latent

45

for adenovirus replication what early proteins are enzymes involved with DNA synthesis

thymidine kinase
DNA polymerase

46

where does replication and viral assembly occur for adenovirus

nucleus
-grapelike cluster of virus particles

47

What are the two important adenovirus types

4 and 7

48

adenoviurs Type 7 and 3 have what clinical feature

pneumonia in children

49

Adenoviurs types 8,7,19 have what clinical features

keratoconjunctivitis
shipyard conjunctivitis

50

what type of vaccine is used for what serotype for adenovirus

live oral vaccine for type 4 and 7

51

how does an oral, live-attenuated vaccine prevent respiratory disease

- increase IgG
- IgG indirectly impacts respiratory