Cytokines

Question 1

IL1 is made by

Answer 1

monocytes, macrophages, B cells, dendritic cells and endothelial cells

Question 2

The target tissues for IL1 are

Answer 2

Th cells
Hepatocytes
Hypothalamus

Question 3

The function if IL1 is

Answer 3

costimulatory, acute phase induction, fever production

Question 4

IL2 is made by

Answer 4

Th1 cells

Question 5

The target tissue of IL2 is

Answer 5

activated Th cells and cytotoxic lymphocytes

Question 6

The function if IL2 is

Answer 6

proliferation and enhanced killing

Question 7

IL3 is made by

Answer 7

The helper cells

Question 8

The target tissue for IL3 is

Answer 8

hematopoietic cells

Question 9

the function of IL3 is

Answer 9

growth factor

Question 10

IL4 is made by

Answer 10

Th2 cells

Question 11

IL4 target tissue is

Answer 11

B cells

Question 12

IL4 function

Answer 12

activation class switching to IgE and IgG

Question 13

IL5 is made by

Answer 13

Th2 cells

Question 14

IL5 target tissue is

Answer 14

B cells

Question 15

Activity of IL5 is

Answer 15

class switching to IgA

Question 16

IL6 is activated by

Answer 16

macrophages and Th2 Cells

Question 17

The target tissue for IL6 is

Answer 17

B cells hepatocytes, and hypothalamus

Question 18

The activity of IL6 is

Answer 18

differentiation in to plasma cells and Ab production
acute phase protein induction
fever production

Question 19

IL7 is secreted by

Answer 19

bone marrow, thymic stromal cells

Question 20

target tissue for IL7 is

Answer 20

B and T cell precursors

Question 21

Function if IL7

Answer 21

differentation

Question 22

IL-8 is secreted by

Answer 22

macrophages

Question 23

IL-8 target cell or tissue is

Answer 23

neutrophil

Question 24

Activity of IL8 is

Answer 24

chemotaxis

Question 25

IL-10 is secreted by

Answer 25

macrophages

Question 26

Target tissue for IL-10 is

Answer 26

macrophaes and Th2 cells

Question 27

Activity of IL-10 is

Answer 27

down regulation of the inflammatory response

Question 28

IL-12 is secreted by

Answer 28

macrophages

Question 29

target tissue for IL-12 is

Answer 29

Th cells

Question 30

Function if IL-12 is

Answer 30

promotes differentiation of Th cells into Th1 cells

Question 31

IFN-alpha and IFN-beta is secreted by

Answer 31

luekocytes and fibroblasts

Question 32

target cell tissue for IFN-alpha and beta is

Answer 32

infected cells

Question 33

action of IFN-alpha and beta

Answer 33

inhibits viral production

Question 34

IFN-gamma is secreted by

Answer 34

Th1 cells

Question 35

target cell tissue for IFN gamma is

Answer 35

macrophages

Question 36

IGN-gamma function is

Answer 36

activation of macrophages

Question 37

TNF-alpha is secreted by

Answer 37

macrophages

Question 38

target cell tissue for TNF-alpha is

Answer 38

inflammatory cells

Question 39

Function of TNF-alpha is

Answer 39

induces cytokine secretion and cachexia

Question 40

G-CSF and GM-CSF is secreted by ______________, target cell tissue is _______________ and activity is ______________

Answer 40

macrophages and Th cells bone marrow precursors granulocyte development

Question 41

______is used to boot immunity during chemoteryapy

Answer 41

GM-CSF

Question 42

__________is used to boot immunity prior to BMT

Answer 42

G-CSF

Question 43

________is used to treat anemai

Answer 43

EPO

Question 44

____________attracts T cells and monocytes

Answer 44

RANTES

Question 45

_________ and IL18 induce IFN-gamma production of TH1 cells

Answer 45

IL12

Question 46

IL-12 inducdes differentaion of

Answer 46

TH to Th1

Question 47

anti IL-4 used for

Answer 47

treating serious allergies

Question 48

_________is used to increases success of organ transplants, and experimental treatment of leukemia and melanomas

Answer 48

IL-2

Question 49

________is used to treat RA

Answer 49

IL-6 inhibitors

Question 50

monoclonal antibodies to inhibit TNF-alpha are used to treat what diseases

Answer 50

RA, chrons disease and psoriasis

Question 51

________is used to treat HBV, HCV, and HHV-8

Answer 51

IFN alpha

Question 52

_______used to treat MS

Answer 52

IFN-beta

Question 53

________is used to treat GCD

Answer 53

IFN-gamma