Flashcards in Cytokines Deck (13):
Pyrogen --> fever.
Endothelium to express adhesion molecules --> induce chemokine secretion to recruit leukocytes.
Stimulates growth of helper, cytotoxic, and regulatory T cells.
Supports growth and differentiation of bone barrow stem cells. Functions like GM-CSF.
Induces differentiation into Th2 cells.
Promotes growth of B cells.
Class switching to IgE and IgG.
Promotes differentiation of B cells.
Class switching to IgA.
Stimulates growth and differentiation of eosinophils.
Also secreted from Th2 cells.
--> causes fever and stimulates production of acute-phase proteins.
Chemoattractant for neutrophils.
Differentiation of T cells to Th1 cells.
Activates NK cells.
Also secreted by B cells.
Mediates septic shock.
Causes leukocyte recruitment, vascular leak.
Has antiviral and antitumor properties.
Activates NK cells to kill virus-infected cells.
Increases MHC expression and antigen presentation in al cells.
Modulates inflammatory response.
Inhibits Actions of activated T Cells and Th1.
Secreted by T regulatory cells.
Similar to IL-10. Inhibits inflammation.