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Flashcards in Cytokines Deck (13):
1

IL-1

Macrophage:
Pyrogen --> fever.
Endothelium to express adhesion molecules --> induce chemokine secretion to recruit leukocytes.

2

IL-2

T Cell:
Stimulates growth of helper, cytotoxic, and regulatory T cells.

3

IL-3

T Cells:
Supports growth and differentiation of bone barrow stem cells. Functions like GM-CSF.

4

IL-4

Th2 Cells:
Induces differentiation into Th2 cells.
Promotes growth of B cells.
Class switching to IgE and IgG.

5

IL-5

Th2 Cells:
Promotes differentiation of B cells.
Class switching to IgA.
Stimulates growth and differentiation of eosinophils.

6

IL-6

Macrophages:
Endogenous pyrogen.
Also secreted from Th2 cells.
--> causes fever and stimulates production of acute-phase proteins.

7

IL-8

Macrophages:
Chemoattractant for neutrophils.

8

IL-12

Macrophages:
Differentiation of T cells to Th1 cells.
Activates NK cells.
Also secreted by B cells.

9

TNF-alpha

Macrophages:
Mediates septic shock.
Activates endothelium.
Causes leukocyte recruitment, vascular leak.

10

Interferon-gamma

Th1 Cells:
Has antiviral and antitumor properties.
Activates NK cells to kill virus-infected cells.
Increases MHC expression and antigen presentation in al cells.

11

IL-10

Th2 Cells:
Modulates inflammatory response.
Inhibits Actions of activated T Cells and Th1.
Secreted by T regulatory cells.

12

TGF-beta

Similar to IL-10. Inhibits inflammation.

13

Interferon alpha and beta

Innate defense against viruses.
Primes local uninfected cells (paracrine signaling).
If viral dsRNA, activates:
-RNAse L --> Degrade viral/host mRNA.
-Protein kinase --> inhibit viral/host protein synthesis.