Tumor Suppressors Flashcards Preview

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Flashcards in Tumor Suppressors Deck (15):
1

APC

Colorectal cancer (FAP).

2

BRCA1/2

DNA repair protein.
Breast and ovarian cancer.

3

CPD4/SMAD4

DPC
"Deleted in pancreatic Cancer"
Pancreatic cancer

4

DCC

DCC
"Deleted in colon cancer"
Colon cancer

5

MEN1

MEN1

6

NF1

Ras GTPase activating protein (neurofibromin)
Neurofibromatosis 1

7

NF2

Merlin (schwannomin) protein
Neurofibromatosis 2

8

p16

Cyclin-dependent kinase inhibitor 2A.
Melanoma

9

p53

Transcription factor for p21, blocks G1 -> S phase.
Most human cancers, Li-Fraumeni syndrome.

10

PTEN

Breast cancer, prostate cancer, endometrial cancer.

11

Rb

Inhibits E2F; blocks G1 -> S phase.
Phosphorylate to inactivate.
Retinoblastoma, osteosarcoma.

12

TSC1

Hamartin protein
Tuberous sclerosis

13

TSC2

Tuberin protein
Tuberous sclerosis

14

VHL

Inhibits hypoxia inducible factor 1a
von Hippel-Lindau disease

15

WT1/2

Wilms Tumor (nephroblastoma)