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Step1 > Tumor Suppressors > Flashcards

Tumor Suppressors Flashcards

1
Q

APC

A

Colorectal cancer (FAP).

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2
Q

BRCA1/2

A

DNA repair protein.

Breast and ovarian cancer.

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3
Q

CPD4/SMAD4

A

DPC
“Deleted in pancreatic Cancer”
Pancreatic cancer

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4
Q

DCC

A

DCC
“Deleted in colon cancer”
Colon cancer

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5
Q

MEN1

A

MEN1

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6
Q

NF1

A

Ras GTPase activating protein (neurofibromin)

Neurofibromatosis 1

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7
Q

NF2

A

Merlin (schwannomin) protein

Neurofibromatosis 2

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8
Q

p16

A

Cyclin-dependent kinase inhibitor 2A.

Melanoma

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9
Q

p53

A

Transcription factor for p21, blocks G1 -> S phase.

Most human cancers, Li-Fraumeni syndrome.

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10
Q

PTEN

A

Breast cancer, prostate cancer, endometrial cancer.

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11
Q

Rb

A

Inhibits E2F; blocks G1 -> S phase.
Phosphorylate to inactivate.
Retinoblastoma, osteosarcoma.

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12
Q

TSC1

A

Hamartin protein

Tuberous sclerosis

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13
Q

TSC2

A

Tuberin protein

Tuberous sclerosis

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14
Q

VHL

A

Inhibits hypoxia inducible factor 1a

von Hippel-Lindau disease

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15
Q

WT1/2

A

Wilms Tumor (nephroblastoma)

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Step1 (14 decks)

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