Oncogenes Flashcards Preview

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Flashcards in Oncogenes Deck (10):
1

Bcr-able

Tyrosine kinase.
CML, ALL

2

Bcl-1

anti-apoptotic molecule.
Follicular and undifferentiated lymphomas.

3

BRAF

Serine/threonine kinase.
Melanoma

4

C-kit

Cytokine receptor (for stem cell factor).
Gastrointestinal stromal tumor (GIST)

5

C-myc

Transcription factor.
Burkitt lymphoma

6

HER2/neu (c-erbB2)

Tyrosine kinase.
Breast, ovarian, gastric carcinomas.

7

L-myc

Transcription factor
Lung tumor

8

N-myc

transcription factor.
Neuroblastoma.

9

Ras

GTPase.
Colon cancer, lung cancer, pancreatic cancer.

10

Ret

Tyrosine kinase.
MEN 2A and 2B.