Tumor Markers Flashcards Preview

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Flashcards in Tumor Markers Deck (11):
1

Alkaline Phosphatase

Metastases to bone,
liver,
Paget disease of bone,
seminoma (placental ALP).

2

alpha-fetoprotein

HCC
Hepatoblastoma
Yolk sac (endodermal sinus) tumor
Testicular cancer
Mixed germ cell tumor (co-secreted with beta-hCG)

3

beta-hCG

Hydatidiform moles
Choriocarcinomas (gestational trophoblastic disease)
Testicular cancer

4

CA-15-3/CA-27-29

Breast cancer

5

CA-19-9

Pancreatic adenocarcinoma

6

CA-125

Ovarian cancer

7

Calcitonin

Medullary thyroid carcinoma.

8

CEA

Carcinoembryonic antigen.
Nonspecific but 70% of colorectal and pancreatic cancers
Also gastric, breast, medullary thyroid

9

PSA

Prostate-specific antigen.

10

S-100

Neural crest origin (e.g. melanomas, neural tumors, schwannomas, Langerhans cell histiocytosis)

11

TRAP

Tartrate-Resistant Acid Phosphatase.
Hairy cell leukemia (B Cell neoplasm)