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Flashcards in deck 11 Deck (31):
1

What 3 bacteria should we usually think about in the case of purpura fulminans?

Group A strep (S. pyogenes)Staphylococcus aureusNeisseria meningiditis(Also remember he said bacillus cereus had also been identified as a cause!)

2

If you had all the drugs/interventions you needed for the following case…what would you use? [7 items]-104.5 T, BP 60/0, purpuric rash, 3day vomit/diarrhea, highly elevated liver/kidney enzymes, very low calcium/platelets.

vancomycinrifampinclindamycinIVIGvasopressorsFluid and electrolytesdrotrecogin alpha

3

In the case where the man had a near death experience twice with the same bacteria, they found his family to have beta-hemolytic streptococcus group G not group A. What did they treat the family with? [3 drugs]

ceftriaxoneclindamycinrifampin

4

In the case where the man had a near death experience twice with the same bacteria, they found his family to have beta-hemolytic streptococcus group G not group A. Why did he get effected and not everyone else?

He lacked antibodies to SPEA and SPEC

5

In the case where the man had a near death experience twice with the same bacteria, they found his family to have beta-hemolytic streptococcus group G not group A. Once they found out what the issue was, how did they treat him?

Monthly IVIG for a year.

6

What type of drugs are used for T cell lymphoma?

cytotoxic drugs

7

What drug is used to treat USA200 CA-MRSA?

vancomycin

8

What is used in the treatment neutralizing TSST-1?

IVIG

9

Gram +, cocci, beta-hemolytic, catalase negative point to what bacteria?

streptococci

10

What is the final identification test for streptococci bacteria?

lancefield grouping

11

How many serotypes are found in group B strep? What is their serotypes based on?

9capsular polysaccharide

12

How many women are colonized vaginally with group B step? group A strep?

20-40%1/100-1%

13

T-F-- humans acquire group B streptococci from cows/milk?

False

14

What causes bovine mastitis?

Group B strep

15

What is a major way Group B strep is transmitted? What is the relatively less common mode of transmission?

1. fetus and neonate from women vaginally colonized.2. direct contact with breaks in the skin for TSS

16

When is group B strep routinely assessed/screened for?

third trimester

17

How are pregnant women colonized with group B strep treated?

penicillin to reduce colonization

18

What are the 3 cell surface virulence factors of group B strep

1. antiphagocytic caps. polysaccharide.2. C5a peptidase3. Surface proteins alpha and beta

19

How many cases of early onset sepsis with group B strep occur in the US each year?

10,000

20

What is the outcome of fetal/neonate sepsis of group B strep?

30-50% fatality

21

True or false- neonates do not show fever often?

true

22

What is a very important sign of bacterial infection in neonates?

lethargy

23

How many cases of late onset meningitis from group B strep happen in the US/ year?

10,000often seen in neonates greater than 5 days but less than one year

24

What are the 2 types of vaccines being developed for group B strep.?

1. capsular polysaccharides (type specific)2. C5a peptidase (not type specific)

25

T-F---group C strep will often cause pharyngitis, but group G will not?

False---both can cause pharyngitis

26

T-F---group G strep can cause toxic shock syndrome, but group C never does?

False---both can cause

27

What is the name of group D strep?

Streptococcus bovis

28

T-F---group D strep is beta hemolytic?

Falseit is either non-hemolytic or alpha hemolytic

29

What is group D strep often associated with?

gastrointestinal malignancy[not known if it is the cause or grows as the result of]

30

What 3 things is streptococcus bovis occasionally associated with?

1. endocarditis2. UTI3. sepsis

31

What is the function of the surface proteins alpha and beta in group B strep?

unknown but it is known they are required for virulence.