Introduction and Basic Bacteriology Lecture 1 Flashcards
(42 cards)
A high fever, e.g. 107.5 F is most likely to be caused by what type of microbe?
Bacteria
A purpuric rash is a sign of _. What causes it? What is the “fancy name”?
Disseminated intravascular coagulation, blood clotting
Blood leaking into skin because of loss of clotting factors, increased vascular permeability
Purpura fulminans
An elevated AST and ALT is a sign of damage to what organ? What about CPK and creatinine?
AST and ALT - liver damage
CPK and creatinine - muscle damage
There are 4 major bugs that cause purpura fulminans. What are they?
Neisseria meningitidis
Streptococcus pyogenes
Staphylococcus aureus
Bacillus Cereus
Among the following 3 microbes, which is / are gram negative? Which is / are gram positive?
Neisseria meningitidis
Streptococcus pyogenes
Staphylococcus aureus
Neisseria meningitidis - negative (n for negative)
Streptococcus pyogenes - gram +
Staphylococcus aureus - gram +
What is the major type of cell where staphylococcus aureus can be found?
On epithelial cells
Based on case 1 as presented, what is the drug used to treat MRSA? What is the drug used to shut off exotoxin production? What is the use of rifampin in the case?
MRSA - Vancomycin
Shut off exotoxin - Clindamycin
Rifampin - Nisseria meningitis
In case 1 as presented, what was the reason for suggesting that intravenous immunoglobulin (IVIG) be used? What is a drawback to its use?
IVIG can be used to neutralized superantigen exotoxins
It is expensive
From case 1, what were the 3 reasons for recommending treatment with drotrecogin-α ? What is another name for drotrecogin-α
- Antithrombotic
- Antiinflammatory
- Fibrinolytic properties
Activated protein C
In cases of post-influenza toxic shock syndromes (TSS), what is the major microbe that causes the main secondary infection following influenza? What are the 2 main super antigens responsible to the TSS?
Staphylococcus aureus
Toxic Shock Syndrome toxin 1
Staph Enterotoxin B
What is a major visible sign / symptom that is caused by toxic shock syndrome as identified in the lecture?
Purpura fulminans
A microbe that is the most significant cause of serious infections and deaths from infections according to the CDC is _
Staph aureus
What are the top 2 (in order) causes of blood stream infections?
Staphylococcus epidermis
Staphylococcus aureus
What is the number 2 cause of pneumonia?
Staphylococcus aureus
What is the Number 1 cause of infective endocarditis and osteomyelitis?
Staphylococcus aureus
In 430 - 427 BC, patients were described as having “Violent heats in the head, inflammation of eyes and throat, reddish livid skin, extreme diarrhea, and high fever.” Then it was called _. Now it is recognized as _
Thucydides Syndrome
Post-influenza staphylococcal TSS
True or false, the case to fatality ratio following influenza pandemics have increased over the years. Why is this the case?
False, the fatalities have actually dropped
Increases in medical knowledge
What is the main cause of mortality following influenza? Why?
Bacterial infections following the flu
Influenza and other viral infections leave patients transiently immuno-compromised
Following the 1918 influenza pandemic, what were the 3 main causes of secondary bacterial infections responsible for fatalities?
Haemophillus influenza
Streptococcus pneumoniae
Staphylococcus aureus
What is the moiety expressed on human epithelial cells that allow viral entry? What is the viral protein that binds this moiety?
Sialic acid
Hemagglutinin
Hemagglutinin (HA) requires a protease-dependent maturation event to expose the sialic acid binding site. What are the molecules that cleave and activate HA?
Serine proteases
What is the moiety expressed by the flu virus that is required for its exit from the host cell? What drug targets this moiety?
Neuraminidase
Oseltamivir (Tamiflu)
Co-infection with influenza virus and S.aureus have a higher case:fatality rate. What are 2 reasons?
- S. aureus proteases activate influenza HA, allowing
viral infection - TSST-1+ S. aureus produce exceptionally high levels of proteases, including serine proteases
A fever that is characterized as low temperature and lower PMN elevation / inflitration is likely to be caused by what type of microbe?
Virus
