Micro Drugs, Exam 1 Flashcards Preview

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Flashcards in Micro Drugs, Exam 1 Deck (74)
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1

Vancomycin

"MRSA coverage
Blocks cross linking of newly synthesized cell wall to existing cell wall, Binds D-Ala dipeptide
Requires 12 hrs to work "

2

Clindamycin

"Shuts down exotoxin production (Protein synth. Inhibitor)
May allow growth of clostridium dificile, causing pseudomembranous enterocolitis "

3

Rifampin / rifamycin

"Great mucosal penetration
Prophylactic for meningitis (neisseiria won't develop resistance), treats Tuberculosis
Turns urine and contact lenses red
Inhibits initiation of transcription"

4

IV Immunoglobulin

Neutralizes superantigen

5

Drotecogin alpha, activated protein C

"Anti-thrombotic, anti-inflammatory and fibrinolytic
Slows clotting in purpura fulminans "

6

Corticosteroids

Prevent Inflammation if damaging (e.g. meningitis)

7

Phosphonomycin

"Class???
Acts in Cytoplasm
PEP analogue, block UDP-NAG to UDP-NAM"

8

D-Cycloserine

"Acts in Cytoplasm
Blocks addition of terminal D-ala dipeptide to UDP-NAM
Good for TB (second line)"

9

Bacitracin

"
Acts in membrane
Blocks regeneration of bactoprenol pyrophosphate, required cell wall precursor carrier (Blocks pyrophosphatase
Group A strep VERY sensitive"

10

Penicillins

"Beta-lactams
Block the transpeptidation reaction, displaces terminal D-Ala
Acts on the cell surface
Binds Penicillin binding proteins (PBP)"

11

Cephalosporins

"Beta-lactams
Block the transpeptidation reaction, displaces terminal D-Ala
Acts on the cell surface
Binds Penicillin binding proteins (PBP)"

12

Monobactam

"Beta-lactams
Block the transpeptidation reaction, displaces terminal D-Ala
Acts on the cell surface
Binds Penicillin binding proteins (PBP)"

13

Carbapenems

"Beta-lactams
Block the transpeptidation reaction, displaces terminal D-Ala
Acts on the cell surface
Binds Penicillin binding proteins (PBP)"

14

What are 4 beta lactams?

"Penicillin
Cephalosporin
Monobactam
Carbepenem"

15

Clavulanic Acid

"Inactivates Beta-lactamases
Used with Amoxicillin as Augmentn "

16

What beta lactams have S group, leading to sensitivity?

"Penicillin
Cephalosporin
Carbepenem"

17

What PBP confers resistance to beta lactams? Most common in _

PBP2a, Staph Aureus

18

Benxyl Penicillin (Pen G)

"Penicillin
Beta lactamase sensitive, good Gram + activity"

19

Phenoxymethyl Penicillin (Pen V)

"Penicillin
Beta lactamase sensitive, good Gram + activity"

20

Procaine Penicillin

"Penicillin
Beta lactamase sensitive, good Gram + activity"

21

Methicillin

"Penicillin
Penicillinase Resistant, Good gram + activity "

22

Oxacillin

"Penicillin
Penicillinase Resistant, Good gram + activity "

23

Nafcillin

"Penicillin
Penicillinase Resistant, Good gram + activity "

24

Cloxacillin

"Penicillin
Penicillinase Resistant, Good gram + activity "

25

Dicloxacillin

"Penicillin
Penicillinase Resistant, Good gram + activity "

26

Flucoxacillin

"Penicillin
Penicillinase Resistant, Good gram + activity "

27

Amoxicillin

"Penicillin
Moderate Spectrum "

28

Ampicillin

"Penicillin
Moderate Spectrum "

29

Piperacillin

"Penicillin
Moderate Spectrum "

30

Augmentin

"Penicillin
Amox + Clavulanic acid
Extended Spectrum "