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Flashcards in Dementia, Cohen I Deck (47)
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1

cognition

mental process of knowing, including aspects like awareness, perception, reasoning and judgement

2

dementia defintion

deterioration cognition, higher intellectual process, organic disease of brain

3

DSM IV

development of multiple cognitive deficits that are sufficiently severe to cause impairment in occupational or social functioning

4

is dementia reversible

irreversible

5

common initial presentation of dementia

delirium

6

primary causes of dementia

----alzheimers
--lewy body dementia/Parkinsons
--multi infarct/Vascular dementia
--fronto-temporal demential
--alcoholism/VitB12 deficiency
-subdural hematomas, creutzfeldt jacob, HIV, normal P hydrocephalus, tumors, progressive supranuclear palsy, huntington, MS, CTE

7

findings micro in alzheiemrs

plaques of amyloid
tangles of tau- containing microtubules inside neurons

8

what amyloid collects in alzheimers

beta amyloid
AB42 from amyloid precursor protein

9

where is most cell death in alzheimers

temporal and parietal lobes

10

major connection to alzheimers

downs by age 50 60s

11

what NT is lost in alzheimers

Ach

12

what collection amyloid or tau is thought to have role in dementia

tau
amyloid blockers or lowering agents not helpful in alzheimers

13

prevalence of Alzheimers

>80 majority
>65 common
M

14

associations with development of alzheimers

mentally inactive people
victims head trauma
homozygous e4 allele ApoE

15

begining of alzheimers

loss of memory for recent information or events like appointments
objects misplaced
trouble recalling names of DISTANT friends at first
repeating stories
restricted speech, cannot complete sentence

16

progression alzheimers

visuospatial decline (wandering)
gait disorder with dizziness and poor posture (extension)

17

mental state alzheimers

boredom, lack of social inhibitions
irritability
paranoia
denial relationships
depression
can become violent or anxious and agitated

18

what is "sundowning"

confusion and agitation at night

19

apraxia

loss of simple actions because loss of connections between cortical sites
(inability to button clothing or brush hair etc)

20

Mild alzheimers

safe at home
some help with acticities
not threat to self

21

moderate alzheimers

kept at home with great effort
full or nearly full caregiver

22

severe alzheimers

nursing home or assisted liviing for round-the-clock supervision

23

Dx of alzheimers

clinical

24

What is PiB

pittsburgh compound that binds to beta amyloid deposition in brain

25

amyloid levels and tau levels in CSF in alzheimers

dec beta amyloid
increase tau
(soluble)

26

MRI of alzheimers

atrophy in medial temporal lobes

27

Must rule out for Dx alzheimers

B12
thyroid
renal and hepatic problems

28

thought behind ACHE inhibitors in alzheimers

increase Ach for relief memory impairment, agitated behavior and concentration

29

effect of ACHEI in alzheimers patients

modest gains with slower decline
no major difference than non-Tx patients in 2-3 years

30

ACHEI used in alzheimers

donepezil
rivastigmine
galantamine