Pharm Anesthetics, Kinder II Flashcards Preview

Year 2 neuro exam 2 > Pharm Anesthetics, Kinder II > Flashcards

Flashcards in Pharm Anesthetics, Kinder II Deck (53)
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1

what barbituates are used for IV anesthetic

thiopental and methohexital

2

MOA thiopental and methohexital

GABAa R increase channel opening duration
inhibit excitatory too

3

which barbituate has shorter elimination

methohexital

4

CNS effects thiopental and methohexital

dose dependent CNS depression
no analgesia

5

which barbituate anesthetic cannot be used for anticonvulsant

methohexital

6

respiratory effects thiopental and methohexital

depressors
transient apnea

7

use of thiopental and methohexital

induction anesthesia
propofol used more

8

what benzos are used perioperatively

midazolam
lorazepam
diazepam

9

MOA benzos

GABAa increase sensitibity to GABA and enhance inhibitory NT

10

benzos can be terminated by administration of what

flumazenil

11

what benzo is suitable for coninuous infusion

midolazam

12

CNS effects benzos

anticonvulsants- status epilepticus, alcohol withdrawal, local anesthetic induced seizure

13

resp effects benzos

severe resp depression if given with opioid

14

therapeutic use benzos

produce anxiolysis and anterograde amnesia

15

MOA etomidate

GABA like effects thorugh GABAa and Cl channels

16

metabolism etomidate

urine excretion and bile

17

CNS effects etomidate

cerebral vasoconstrictor
dec blood flow and ICP

18

CV effects etomidate

minimal hemodynamic effects! good for those with compromised cardiac contractility prior to anesthesia

19

endo effects etomidate

adrenocortical suppression
inhibits 11bhydroxylase for cholesterol -->cortisol

20

use of etomidate

alternative to propofol or barbituates for those with conmprmised cardiac contractility

21

MOA ketamine

inhibition of NMDA R

22

CNS ketamine

cerebral dilator and inc blood flow
can have emergence reactions :vivid color dreams hallucinations etc
"dissociative anesthesia" eyes open with slow nystagmic gaze

23

CV ketamine

can increase BP HR and CO
direct myocardial depressant( mainly critically ill patients)

24

therapeutic use ketamine

profound analgesia, SAN stimulation
bronchodilation
minimal respiratory depression

25

side effect ketamine

lacrimation and salivation increased
so give anticholindergic before administration

26

MOA dexmedetomidine

selective a2 agonist

27

CNS dexmedetomidine

hypnosis from activation a2 in locus ceruleus
analgesia at level spinal cord

28

CV effects dexmedetomidine

mod dec HR and systemic vascular R
bradycardia

29

therapeutic use of dexmedetomidine

short term sedation of intubated and ventilated patients in ICU setting

30

which IV anesthesia does not affect respirattion

dexemedetomidine