Pharm Movement Disorders, Kinder II Flashcards Preview

Year 2 neuro exam 2 > Pharm Movement Disorders, Kinder II > Flashcards

Flashcards in Pharm Movement Disorders, Kinder II Deck (26):
1

types of MAOIs

MAO A metabolizes NE serotinin and dopamine
MAO B metabolizes dopamine selectively

2

MOA Rasagiline

irreversible inhibitor of MAO-B

3

use of rasagiline

neuro protective agent and early symptomatic Tx parkinsons

4

DDI levodopa and nonselective MAOI

leads to HTN crisis from accumulation NE

5

what other drugs not used with MAOI

meperidine
tramadol
methadone
propoxyphene
cyclobenzaprine
OTC cold preparations

6

3- O methyldopa competes with what

levodopa for active carrier mech that transport across intestine and bbb

7

MOA entacapone

prolong action levodopa by diminishing peripheral metabolism

8

use of entacapone

patients wtih response fluctuations

9

entacapone effects

peripheral only, not central effects

10

adverse effects catechol o methyltransferase inhbiitors

increased levodopa exposures
diarrhea, abdominal pain, orthostatic hypotension, sleep disturbances
orange urine!!!!!!!!!

11

Amantadine

antiviral agent with weat anit parkinism properties

12

what parkinson drug can cause lived reticularis skin condition

amantadine

13

CI amantadine

Hx of seizures or heart failure

14

MOA benztropine

mAChR antagonist

15

use of benztropine

may improve tremor and rigidity in parkinsim
little effect on bradykinseia

16

adverse effects benztropine

peripheral antimuscarinic effects like sedation, mental confusion constipation urinary retention and blurred vision

17

most effective Symptomatic Tx for motor disturbances in parkinsons

carbidopa-levadopa
no dopaine agonists

18

severe parkinson and long term complications of levodopa wtich to what theapy

COMT inhibitor or rasagiline

19

what adrenergic R in essential tremor

B1 so respond to propanolol and metoprolol

20

Symptomatic tremors controlled by

antiepileptic drugs like primidone or anticonvulsant topiramate

21

what drugs are helpful in huntingtons

those that deplete dopamine: reserpine and tetrabenzine
dopamine R blockers: olanzapine, phenothiazines, haloperidol!!

22

Tx tics

antipsychotis: tetrabenazine, haloperidol
alpha agonists: clonidine guanfacine
botulinum toxin

23

Tx restless leg syndrome

correct Fe deficiency
dopamine agonists: levodopa, diazepam etc
non-ergot dopamine agonists: pramipexole

24

1st line therapy in patients with daily restless leg syndrome

non-ergot dopamine agonists like pramipexole

25

Tx wilsons disease

penicillamine
potassium disulfide

26

Sx wilsons

tremor
choreiform movements
rigidity
hypokinesia
dysarthria
dysphagia