Pharm HA and migraines Kinder Flashcards Preview

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Flashcards in Pharm HA and migraines Kinder Deck (64)
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1

What drugs are used for Acute Migraine Therapies

serotonin agonists "triptans"
ergot alkaloids
analgesics
combinations analgesics
NSAIDs
antiemetics

2

what drug classes are used for prophylactic migraine therapies

beta antagonists
CaCh blockers
antidepressants
anticonvulsants

3

what are the ergot alkaloids

dihydroergotamine DHE
ergotamine +/- caffeine

4

What are the combination analgesics

aspirin, acetaminophen, caffeine (excedrin)

5

what antiemetics are used for migraines

metoclopramide
prochlorperazine

6

what beta antagonists are used for migrain

metoprolol and propanolol

7

what Ca Ch blocker in migraines

verapamil

8

what antidepressants used in migrain

amitriptyline

9

what antivconvulsant for migraine

topiramate (topomax)

10

what can cause secondary HA

infeciton, cerebral HA, brain mass lesion

11

unilateral HA with crescendo pattern that is pulsatiing and aggravated by physical activity
+ nausea, vomiting and photophobia

migraine

12

bilateral HA with pressure or tightness that waxes and wanes
- nausea vomiting

tension HA

13

unilateral pain around eye that is quick onset deep and excruciating
ipsi lacrimation and redness, rhinorrhea, sweating

cluster

14

aura involves what

nausea, vomiting, visual scotomas, hemianopsia and speech abnormalities

15

pathophys migraine

CN V involvement
release calcitonin gene related peptide CGRP which vasodilates and cause dural plasma extravasation causing inflammation

16

triggers of migraines

food, alcohol, caffeine or withdrawal, chocolate, monoNa glutamate, aspartame
flivkering lights, high altitude, strong smells, tobacco, weather
excess or not enough sleep, fatigue, menstruation, skipped meals, strenuous acitivity

17

most common type primary HA disorder

tension type

18

main stay Tx for preventative of tension type HA

amitriptyline

19

90% serotonin is found where

enterochromaffin cells in GI

20

where is serotonin in blood

in platelets

21

what inactivates serotonin

MAO
monoamine oxidase

22

what is used to detect serotonin secreting tumor

5-IAA which is byproduct of inactivated serotonin

23

CNS serotonin effects

vomiting reflex
pain/itch stimulation

24

CV serotonin effects

contraction vascular smooth m
causes dilation in heart and venoconstriction
promotes platelet aggregation

25

GI serotonin effects

increase tone and perstalsis 5-HT2
motility enhancing 5-HT4

26

skel mm serotonin effects

contraction when MAO inhibitors given with serotonin agonists

27

What are the serotonin agonists

triptans
5-HT1D/1B

28

triptans used for what HA

migraine

29

MOA sumatriptan

activates R on presynaptic CN V endings inhbiiting vasodilatory peptides and stimulates vasoconstriction

30

PK sumatriptatn

MAO
shorter duration