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Flashcards in Dementia, Cohen II Deck (27):
1

multi infarct dementia

clincally Hx stokes and hemorrhagic strokes
Step like downhill course

2

clinical findings multi infarct dementia

focal findings on exam: aphasia, dysarthria, hemiparesis, spasticity, visual field cuts

3

seizures are more common in what type dementia

multi infarct

4

likely concurrent comorbidities in multi infarct dementia

coronary artery disease
peripheral vascular disease
carotid stenosis

5

What are risk factors for multi infarct dementia

HTN
DM
HLD
obesity, inactivity
smokers, alcohoics
known CAD, or Afib

6

Tx of those at higher risk for multi infarct dementia

control risk factors
aspiring and other inhibitors of platelet aggregation
anti coagulants

7

Fronto-temporal Lobar Dementia

family of multiple disorders with dementia
decline in behavior and speech!!

8

autopsies and MRI of fronto-temporal lobar dementia

visible degeneration of frontal lobes and anterior temporal lobes!! MRI!!
increased tau!
TDP43!! and ubiquitin!!
M=W

9

onset fronto temporal lobar degeneration

younger than AD
50s early 60s
"Picks"

10

Dx frontotemporal dementia

MRI! frontal and anterior temporal lobe degeneration

11

clinical features frontotemporal dementia

major personality changes like inappropariate actions, apathy, loss sexual inhibitions no concern appearance
shoplifting!
no ability to plan acitivites
become obsessed with certain subjects, clap hands inappropriately
over eat over drink

12

frontotemporal dementia similar to what

ALS patients

13

memory loss in frontotemporal dementia

later on

14

Language form of frontotemporal dementia

progressive aphasia like Brocas
L hemisphere more atrophy than R
sentences shorter and shoter with progressive inability to name and read and write

15

how to Dx frontotemporal dementia clinically

say things totally irrelevant
cannot name subject
gait ataxia
slow movements
poor decision making

16

what tx help in frontotemporal dementia

antidepressants
sometimes antipsychotics

17

What is Transmissible Spongiform Encephalopathy

CJD from prions

18

what is prion

proteinaceous particles that can reporduce without nucelic acids

19

progression CJD

rapid dementia over 1 year
prominent myclonic jerks
loss of balance and coordination, mildy extrapyramidal and sometimes cerebellar signs
occasionally familial

20

Dx CJD

rapid downhill course
EEG triphasic waves
CSF: high levels 14-3-3 protein

21

MRI CJD

rapidly accumulating subcortical deposits in cerebral hemispheres and cerebellar deposits sometimes

22

brain Bx of CJD

prions and spongiform changes with loss of neurons and gliosis

23

triad signs of normal pressure hydrocephalus

gait disturbance
incontinence
dementia
Wet Wide Weird

24

1st sign normal P hydrocephalus

gait disturbance
wide based

25

type of dementia in normal P hydrocephalus

decreased attention space
mental slowing
disorientation, confusion
depression

26

MRI in normal P hydrocephalus

huge ventrilces
less prominent sulci

27

Tx Norm P hydrocephalus

take off CSF like 20-30 cc