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pharmacology II > Dermatologic > Flashcards

Flashcards in Dermatologic Deck (52)
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1

Routs of administration for skin

- topical
- systemic
- intralesion injection
- ultraviolet radiation

2

Topical drug deliverry forms for derm

- solution/dissolved in solvent
- lotion/powder in water or oil
- cream/wanter in oil
- ointment/oil in water

3

what can increase the skin penetration of an agent

- decreased molecular size
- increased lipid content
- increased concentration
- decreased skin integrity
- decreased skin thickness, ie face vs heels
- greater surface area to mass - greater dose

4

Lists of the dermatologic agents

- anti/bacterial/fungal/virals/inflammatories
- retinoids
- psoralens
- sunscreens
- keratolytic agents salicylic acid
- analgesics
- hormone replacement
- nicotine
- alopecia drugs
- cytotoxic agents

5

why use topical antimicrobials

prophylaxis of superficial infections due to wounds and injuries

6

What are the topical antimirobials

- Anti microbrial: Neomycin/Neosporin
- Antibiotic : Mupirocin/bactroban

7

MOA of antimicrobial Neomycin/neosporin

Neomycin: disrups bacterial cell membrane phospholipids

8

MOA of antimicrobial Bacitracin

Bacitracin: interferes with pepditoglycans of bacterial cell wall

9

MOA of Topical antibiotic Mupirocin/bactroban

Mupirocin/bactroban: inhibit bacterial protein synthesis

10

Neomycin Class

Antimicrobial: disrubt cell membrane

11

Bacitracin class

antimicrobial : disrupt cell wall

12

Mupirocin/bactroban Class

Antimicrobial: inhibit protein synthesis

13

Indication for Neomycin ointment

Neomycin/neosporin
- superficial skin infection,
- external ear infx
- prophylactially

14

Indication fo Mupirocin
- cream or ointment

Mupirocin/bactroban
- impedigo
- staph/strep
- MRSA in additon to IV

15

side effects of Neomycin ointment

Neomycin:
- Ototoxicity if otic solution is applied and there is a perforated TM

16

where should you apply Mupirocin when treating MERA

Also treat nares

17

Antifungals : topical

Ketoconazole/Nizarol

18

MOA of ketoconazole/nizarol

Ketoconazole: Inhibit sterol synthesis

19

Class of ketoconazole

antifungal

20

Indication of KEtoconalzole
- lotion, ointment, shampoo

superficial fungal infections
- Tinea
- yeast infections
- seborrheic dermatitis

21

why apply glucocorticoids to skin, what are their properties

- immunosupressive
- antiinflammatorie

22

when should topical steroids be avoided

Dont use topical steroids and abraded skin

23

indications for topical glucocorticoids

- dermatitis
- psoriasis
- ezcema
- bullous disease : pemphigus
- collagen vascular disease SLE
- Granulomatous : Sarcoidosis

24

How are topical glucocorticoids classed?

Grouped into seven classes with class 1 being the most potient and class 7 is the least potent.

25

what are generally the most potent corticosteroids

halogenated corticosteroids

26

steroid side effects

- skin atrophpy
- striae
- purpura
- perioral dermatitis *
- rosacea
- fungal overgrowth

27

Systemic side effects from topical steroid

- supression of HPA axis
- hyperglycemia
- osteoporosis/necrosis

28

what can increase systemic absorption of topical steroids

- increase amount applied
- size of treatment area
- frequency of application
- duratio nof treatment
- drug potency
- use of occlusive barrier

29

when are intralesional steroids used

- cystic acne
- psoriasis
- discoid lupis
- alopecia

30

Glucocorticoid/corticosteroid drug

Hydrocortisone/cortef