Dermatologic Flashcards Preview

pharmacology II > Dermatologic > Flashcards

Flashcards in Dermatologic Deck (52):
1

Routs of administration for skin

- topical
- systemic
- intralesion injection
- ultraviolet radiation

2

Topical drug deliverry forms for derm

- solution/dissolved in solvent
- lotion/powder in water or oil
- cream/wanter in oil
- ointment/oil in water

3

what can increase the skin penetration of an agent

- decreased molecular size
- increased lipid content
- increased concentration
- decreased skin integrity
- decreased skin thickness, ie face vs heels
- greater surface area to mass - greater dose

4

Lists of the dermatologic agents

- anti/bacterial/fungal/virals/inflammatories
- retinoids
- psoralens
- sunscreens
- keratolytic agents salicylic acid
- analgesics
- hormone replacement
- nicotine
- alopecia drugs
- cytotoxic agents

5

why use topical antimicrobials

prophylaxis of superficial infections due to wounds and injuries

6

What are the topical antimirobials

- Anti microbrial: Neomycin/Neosporin
- Antibiotic : Mupirocin/bactroban

7

MOA of antimicrobial Neomycin/neosporin

Neomycin: disrups bacterial cell membrane phospholipids

8

MOA of antimicrobial Bacitracin

Bacitracin: interferes with pepditoglycans of bacterial cell wall

9

MOA of Topical antibiotic Mupirocin/bactroban

Mupirocin/bactroban: inhibit bacterial protein synthesis

10

Neomycin Class

Antimicrobial: disrubt cell membrane

11

Bacitracin class

antimicrobial : disrupt cell wall

12

Mupirocin/bactroban Class

Antimicrobial: inhibit protein synthesis

13

Indication for Neomycin ointment

Neomycin/neosporin
- superficial skin infection,
- external ear infx
- prophylactially

14

Indication fo Mupirocin
- cream or ointment

Mupirocin/bactroban
- impedigo
- staph/strep
- MRSA in additon to IV

15

side effects of Neomycin ointment

Neomycin:
- Ototoxicity if otic solution is applied and there is a perforated TM

16

where should you apply Mupirocin when treating MERA

Also treat nares

17

Antifungals : topical

Ketoconazole/Nizarol

18

MOA of ketoconazole/nizarol

Ketoconazole: Inhibit sterol synthesis

19

Class of ketoconazole

antifungal

20

Indication of KEtoconalzole
- lotion, ointment, shampoo

superficial fungal infections
- Tinea
- yeast infections
- seborrheic dermatitis

21

why apply glucocorticoids to skin, what are their properties

- immunosupressive
- antiinflammatorie

22

when should topical steroids be avoided

Dont use topical steroids and abraded skin

23

indications for topical glucocorticoids

- dermatitis
- psoriasis
- ezcema
- bullous disease : pemphigus
- collagen vascular disease SLE
- Granulomatous : Sarcoidosis

24

How are topical glucocorticoids classed?

Grouped into seven classes with class 1 being the most potient and class 7 is the least potent.

25

what are generally the most potent corticosteroids

halogenated corticosteroids

26

steroid side effects

- skin atrophpy
- striae
- purpura
- perioral dermatitis *
- rosacea
- fungal overgrowth

27

Systemic side effects from topical steroid

- supression of HPA axis
- hyperglycemia
- osteoporosis/necrosis

28

what can increase systemic absorption of topical steroids

- increase amount applied
- size of treatment area
- frequency of application
- duratio nof treatment
- drug potency
- use of occlusive barrier

29

when are intralesional steroids used

- cystic acne
- psoriasis
- discoid lupis
- alopecia

30

Glucocorticoid/corticosteroid drug

Hydrocortisone/cortef

31

MOA or glucocoricoids

- affects gene transcription: anti inflammatory
- stimulate or repression protein synthesis

32

how is hydrocortizone dispensed

topical cream or ointment
- OTC 1% or halogenated

33

How do retinoids affect skin

Modify the following
- cell proliferation
- cell differentiation
- immune function
- inflammation
- sebum production

34

what are Retinoids

derivatives of retinol that exhibit vitamin A activity

35

indications for Retinoids

- Cystic/papular acne
- actinic keratosis
- psoriasis - same as intralesional steroids
- basal cell cancer **
- Squamous cell cancer *
- Cutaneous aging

36

Etiology of acne

- Folicular hyperkeratosis
- bacteria
- excess sebum produciton
- increased inflammation
- andrognes

37

Drug therapy for acne includes what

- topical salicylic acid
- topical benzoly peroxide
- topical antibiotics
- topical retinoids

38

Class of tretinoin/Retin A

Vitamin A derivative

39

MOA of Tretinoin/Retin A

MOA Retin A
- Reduce hyperkeratinizaation, increase epidermal thickness and collagen synthesis

40

side effects of Retin A

Erythema,
peeling
burning
stingin
photosynsetivity

41

name the Vitamin A derivatives

Tretinoin/Retin A
Isoretinoin/Accutane

42

MOA or Isoretinin/Accutain

MOA of isoretinin/accutain
- Reduce hyperkeratinization, sebum gland number and production, reduce bacteria

43

what bacteria is associated with acne

propioni-bacterium acne

44

indications for Tretinoin/retin A vs Isoretinin/accutaint

Trentinoin/Retin A
- Acne
- photodamaged skin
Isoretinin/Accutane
- Acne
- Acne rosacea
- Hidradenitis supperativa

45

Side effects of Accutaine

Teratogenicity - first 3 weeks of gesttion
Pregnancy is absolute contraindications
2 forms of birth control
- depression/ psycosis
liver stuff

46

Psoriasis

Autoimmune dz, immune cells move to epidermis, stimulating proliferation of keratinocytes

47

Drug therapy for psoriasis

- Topical corticosteroids
- Topical vitamin D
- Topical vitamin A
- Phototherapy
- Systemic: steroids, chemo agents,

48

What does photochmotherapy implies

That some sort of drug is added to tratment

49

PUVA

Psoralen and ultraviolet A therapy. Geven Psoralen then reacted to UVA light

50

MOA of PUVA

MOA of PUVA
- antiinflammatory through immunosupression
- inhibit DNA synthesis

51

Uses for PUVA

- Psoriasis (retinoids, intralesional steroids)
- vitilago
- T cell lymphomas
- alopecia
- urticari pigmentosa

52

side iffects of PUVA

nausea, pain redness, blistering,
increased risk of skin cancer
skin aging; actinic keratosis