Diabetes Type 2 MOA Flashcards Preview

pharmacology II > Diabetes Type 2 MOA > Flashcards

Flashcards in Diabetes Type 2 MOA Deck (25):
1

Metformin

Biguinides
Decrease hepatic glucose
ingrease glucose sensitivity
NO Hypoglycemia

2

Glipizide

Sulonyreas - 2nd gen
secreatagogues: increase insulin secretion
Yes - Hypo

3

what are the three meds that cause hypoglycema alone

Glipizide: sulfonylureas
sitiglitatin: DPP4
Nateglinide: Meglitinides

4

Nateglinide

meglitinide: secretagogues, increase insulin secretion
(Potassium channel blocking)
Yes hypo

5

roxiglitazone

Glitazones:
decrease insulin resistance
decrease hepatic glucose production
PPAR gene
No - Hypo
Yes- increase risk CHF

6

acarbos

A glucosidease inhibitor: inhibit carb absorb at brush border
No- Hypo
Not for chronic intestinal issues

7

antidote for Acarbos

Glucose not sucrose

8

sitagliptin

DPP4 inhibitor: supress glucagon, potientiate insulin
Increase risk pancreantitis
Yes- hypoglycemia

9

Pramlintide

Amylin aganoist analogue: slow gastric emptying, supress glucagon
No - Hypoglycemia
first approved in Type 1 since 1920

10

exenatide

incretin mimic: only enhance glucose dependent insulin secretion
slow gastric emptying
NO- hypoglycemia
Gila monster saliva

11

Which osteoporosis drugs Prevent osteoporosis

alandronate: bisphosphonates
Raloxifene: SERM
Prempro: estrogen
Denomaup: human monoclonal antibody
? levostatin: statin
Phytoestrogens: diet

12

Bisphosphenates

Alondronate: inhibit osteoclast activity
Prevention and treatment

13

SERM: selective estrogen receptor modulators

Ralozifene: bind estrogen receptors in bones, but its ant estrogenic in brest and endometrial tissue
Prevention

14

Synthetic calcitonin

Inhibit osteoclast activity
Treatment only

15

synthetic parathyroid hormone

Teriparatide: activate boen turnover with increase osteoblastic activity
Treatment only

16

Estrogen or estrogen =+ progestin

premarin, prempro: activate bone turnover
Prevention

17

human monoclonal antibody

Denosumab: Targets RANKL to quit bone removal signal, it stops bone degredation
PREVENTION

18

Statins

Lovostatin : may lower fracture risk

19

Phytoestrogens

Isoflavones: Bind estrogenic receptor
does not prevent bone loss

20

Thionamide

Methimazole and propylthiouracil
Inhibit transformation of inorganic iodine to organic to block thyroxine production,

21

Thionamide: methimazole

Block thyroxine production , blocks formation of T3 and T4
Little effect on peripheral T4/T3 conversion

22

Thionamide: prophylthiouracil

Block thyroxine produciton, block formatio nof T3 and T4
Large effect on Periperal T4/T3 conversion

23

Beta blocker non selective

Propanolol: treats sympathetic symptoms by blocking beta receptors, not specifically
Thyroid Storm

24

SSKI: Elemental iodine

Stuns thyroid with large doses of iodin that inhibits release of thyroxine
- works for2-3 weeks
Thyroid storm

25

Radioactive iodine isotope

I 131
Beta particles destroy thyroid tissue over several wekks.
Catagory X