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Flashcards in Final - Diabetes Deck (24):
1

MOA biguanides

biguanides: metformin
- Decrease hepatic glucose production and enhance glucose sensitivity
- Caution: lactic acidosis

2

MOA: sulfonylureas

sulfonylureas: Glipizide; glucotrol
- Secreatagogues that stimulate insulin secretion by beta cells.
- caution hypoglycemia
- caution sulfa allergy

3

MOA: meglitinides

meglitinides: Nateglinide/starlix
- secretagogues: stimulate insulin secretion by beta cells
- Caution hypoglycemia

4

MOA: thiazoliniones TZD/glitazones

thiazoliniones: Roxiglitazone/Avandia
- Decrease Peripheral insulin resistance by effecting PPAR
- Decrease glucose production.
- NO hypoglycemia
- Caution: CHF, MI, Osteoporosis

5

MOA : Alpha glucosidase inhibitors

alpha glucosidase inhibitors: Acarbos
- inhibit carb at brush border
- reduce glucose absortion
- NO hypoglycemia
- Antidote: Glucose not sucrose

6

MOA: DPP-4 inhibitors

DPP-4: sitagliptin/Januvia
- competitive inhibition DPP-4
- suppress glucagon secretion
- potientiate insulin secretation
- Caution: Pancreatitis risk

7

MOA: amylin agonist analogues

Amylin agonist analogue: Pramlintide
- slow gastric emptying
- suppress glucagon production
- INJECTABLE
- NO hypoglycemia
**first drug for Type 1 diabetic since insulin in 1920

8

MOA incretin mimetics

Incretion mimetics: Exenatide
- enhance glucose dependent insulin secretion
- suppress glucagon secretion while
- slowing gastric emptying
- Injection
- NO hypoglycemia

9

What drugs do not cause hypoglycemia

Exenatide: incretin mimics
Pramlintide: amylin agonist analogue
Acarbose: alpha glucosidase inhibitors
Roxiglitazone: thiazoliniones/glittazones
metformine: biguinides

10

What drugs do cause hypoglycemia

glipizide: sulfonylureas
Nateglinide: meglitinides

11

The 4 types of insulin from shortest to longest duration

- Rapid/Lispro
- Short/Humulin R
- intermediate/NPH humulin N
- Long/Glargine/lantus

12

ANtidote for insulin over dose

Glucagon

13

Antidote for alpha-glucosidase inhibitors

alpha glucosidase inhibitors: Acarbose
- Glucose not sucrose!

14

Contraindications for alpha glucosidase inhibitors

Alpha glucosidase inhibitors: Acarbose
- NOT for IBD
- NOT for chronic bowel disease

15

Gital monster saliva

exenatide

16

diagnosis of DM

Fasting: >126
Non fasting: >200
Glucose tolerance: >200 at 2-3 hrs

17

two secretagogues

sulfonylurease : glipizide
meglitinides: Nateglinide

18

what DM drug can you not also give insulin

NO insulin with DPP-4: Sitagliptin

19

inhibit glucose production by liver,
decrease insulin resistance

Biguinides: Metformin
TZD thiazoliniones/glitazones: roxiglitizone

20

delay absorption of glucose by intestines

acarbos

21

promote insulin release after meal

DPP-4: sitagliptin

22

stimulate beta cells to secrete insulin

secretagogues
- sulfonureas: glipizide
- Meglitinides: Nateglinide

23

pancreatitis

Sitagliptin: DPP-4

24

two injectable not insulin diabetes drugs

anylin agonis analogue: pramlintide
incretin mimic: exenatide