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Flashcards in osteoporosis 1 Deck (29):
1

How common is osteoporosisi

50% of women over 50 and 25% of men over 50 will have at least 1 osteoporotic fracture.

2

risk factors for osteoporosis that you can't change

women, small stature, increasing age, ethnicity/caucasion or asian, family hx/first degree relatives with fractures

3

risk factors for osteoporosis that you can change

Low Ca and Vitamin D, Low estrogen, inactive lifestyle, smokeing, alcohol, steroids, anticonvulsants.

4

two specific drugs that may increase risk of osteoporosis

glucocorticoids and anticonvulsants

5

what treatmetns are used for osteoporosis

Ca, Vit D, Mg, Strontium, bisphosphonates, SERMS , synthetic calcitonin, PTH analogues, estrogen, monoclonal antibodies

6

when is adding Ca to diet benefitioal to prevent osteoporotic fractures

only before first fracture, after it won't help by itself

7

what may be better absorbable Ca

Calcium citrate

8

why is Vit D important

allows Ca absorption in GI, made in skin

9

Calcitriol is what

perscription form Vit D,

10

caution with calcitriol

may elevate serum Calcium levels and so it must be monitored

11

when is Mg helpful

when given with Ca and Vitamin D

12

what mineral may increase osteoblastic activity

strontium

13

What is approved both for treating and preventing postmenopausal, glucocorticoid incuced osteoporosis

Bisphosphonates, selective estrogen receptor modulator

14

what is Raloxifene

selective estrogen receptor modulator - treat and prevent

15

Calcitonin

Treatment only

16

Teriparatide the PTH analogue

Treatment for postmenpausal and men with high risk of fracture

17

ET?HRT

prevention for postmenopausal osteoporosis

18

denosumab - human nonoclonal antibody

Treatment

19

what drugs are approved for treatment of osteoporosis

Bisphosphonates, selective estrogen receptor modulators, Calcitonin, PTH analogue, and human monoclonal antibodies

20

what drugs are approved for prevention

Bisphosphonates, selective estrogen receptor modulators, ET/HRT

21

MOA bisphosphonates

inhibit osteoclasts to increase bone mass

22

majro problem with bisphosphonates

erosion of esophagus, and they are not very bioabailable, osteonecrosis of jaw, and atypical femur fractures

23

Bisphosphonates

Bisphosphonates: Alendronate/Fosamax

24

Bisphosphonates: Alendronate/Fosamax

Prevent and treat via osteoclas inhibition, once daily

25

SERM - selective estrogen receptor modulators

try to act like estrogen without increasing cancer risk

26

SERM drugs:

Raloxifene/Evista

27

SERM: Raloxifene Evista

increase bone mass, reduce fracture risk and breast cancer by binding to estrogen receptor sites.

28

side effects raloxifene

hot flashes, arthralgias, dvt.

29

contraindicatiosn of SERM: Raloxifene/evista

Pregnant and lclacting woment or those with hx of DVT