Dermatology Flashcards
(108 cards)
1
Q
Skin is …….epithelium
Correct sequence of cell cycle
A
Stratified squamous keratinised
G0-G1-S-G2-M
2
Q
2 layers of stratum germinativum/ Malpighian layer
A
Basal cell layer-melanocytes are present
Prickle cell layer/ stratum spinosum
3
Q
Stratum lucidum is a …..cell layer. Present only in …..
A
Clear cell layer
Palms and soles
4
Q
Stratum corneum is ……cell layer
A
Most superficial
Horny cell layer
5
Q
Define acantholysis. Seen in…..
A
Loss of coherence between epidermal cells
Seen in pemphigus
6
Q
Pterygium of nail seen in ……
Onycholysis is seen in ……
A
Lichen planus
Psoriasis
7
Q
Oil drop, pitting of nails seen in ….
Tinea unguium affects …..
A
Psoriasis
Nail plate
8
Q
Koenen’s periungual fibroma seen in …..
A
Tuberous sclerosis
9
Q
Pinta is caused by …..
Yaws is caused by ….
A
Treponema carateum
Treponema pertenue
10
Q
Scabies Incubation period is …..
Pathognomonic lesion of scabies is …..
A
4 weeks
Burrows
11
Q
Layer of skin where scabies are formed ….
Mc site of scabies in infants : ……(2)
A
Stratum corneum
Scalp and face
12
Q
Most infectious form of scabies
Drug used orally for scabies
A
Norwegian scabies
Ivermectin
13
Q
Psoriasis is most commonly seen on …..
What is koebners phenomenon ?
A
Extensor aspect
Traumatised lesions develop psoriatic lesion - at the site of injury
14
Q
KP is seen in …..(4)
A
- Psoriasis
- Lichen planus
- Lichen sclerosis
- Vitiligo
15
Q
Histopathological lesion in psoriasis. Seen on …layer of skin
A
Munro microabscess- St corneum
16
Q
Severe form of psoriatic arthritis
A
Arthritis mutilans - pencil cup deformity in X-RAY
17
Q
What is auspitz sign?
Rx of choice for psoriasis.
A
Rubbing of skin to remove scales lead to pin point bleeding
PUVA
18
Q
Antibodies of pemphigus are against …..
Attacks ….
Feature of pemphigus (2)
A
Intercellular substance
Desmoglein 3
- Intraepidermal (flaccid) acantholytic bullae
- Oral mucosal lesion
19
Q
Definitive dx of pemphigus
A
Demonstration of antidesmoglein antibodies by direct immunoflorescence on skin biopsy
20
Q
Tense subepidermal bullae are seen in …..
Hailey hailey disease is also known as ….
A
Pemphigoid
Familial benign pemphigus
21
Q
Feature of hailey hailey disease
Features of lichen planus (4)
A
No subepidermal blistering
- Flat topped/plain
- Papules
- Pruritic
- Purple color
22
Q
Histological features of lichen planus (2)
Basal cell shows …..
A
Civatte bodies and wickham’s striae
Vacoular degeneration
23
Q
Feature of lichen planus in oral mucosa
Terms associated with pityriasis rosacea (2)
A
White lacy markings on mucosa
- Herald patch
- Annular collarette of scales
24
Q
What are dermatophytes? It involves….
A
Parasitic fungus/ mycosis that infects the skin
Imperfect fungi of genera-epidermophyton,microsporum,trichophyton
25
Dermatophytes are ….
Where do they infect? Why?
Anamorphic- asexual/imperfect
Skin,hair,nails due to their ability to obtain nutrients from keratinised material
26
Athletes foot is aka ……
Feature
Tinea pedis
1. Severe itching
2. Hyperhydrosis
27
Onchyomyosis is aka…..
Affects ….
Tinea unguium/ ringworm of nail
Affects nail plate
28
Tinea versicolor caused by …..
It is a ……organism
Rx
Malassezia furfur
Dimorphic lipophilic
Ketoconazole and itraconazole are systemic therapy
29
Comedones are …..(4)
1. Small cysts
2. Formed in hair follicles
3. Due to blockage of follicular orifice
4. By retention of sebum and keratinous material
30
Acne vulgaris is caused by …..
Atopic dermatitis is aka…
Obstruction of pilosebacous duct
Itch disease
31
Childhood and adolescent pattern of atopic dermatitis is marked by (2)
1. Flexural skin dermatitis
2. Particularly in antecubital fossa/popliteal fossa
32
Other features of atopic dermatitis (3)
1. Perioral pallor
2. Dennies Morgan Fold- extra fold of skin beneath eyelid
3. Increased palmar markings
33
Best test to dx atopic dermatitis
Basal cell carcinoma of skin spreads …..
Clinical evaluation
Direct spread
34
Conditions predisposing to squamous cell carcinoma of skin (2)
1. Actinic keratosis
2. DLE
35
Mycosis fungoides is AKA…..
Special features (3)
Cutaneous T cell lymphoma
1. Mc skin lymphoma
2. Pautrier’s microabscess
3. Presents with diffuse erythroderma
36
Dermatitis herpetiformis is associated with …..
HLA of dermatitis herpetoformis (2)
Gluten sensitive enteropathy
HLA-DRw3
HLA-DQw2
37
Direct immunoflorescence of normal appearing perilesional skin in DH shows ….
DOC of dermatitis herpetiformis
Granular deposits of IgA
Dapsone
38
Mc endocrinology cause of acanthosis nigricans
Internal malignancy associated with acanthosis nigricans (2)
Type 2 DM
Adenocarcinoma lungs
Carcinoma GIT
39
Pseudopelade alopecia is aka …..(2)
Causes of cicatricial alopecia (4)
Cicatricial alopecia
Scarring alopecia
Lichen planus
Discoid lupus erythromatosis
Lupus vulgaris
SLE
40
Alopecia areata is AKA…
……..is characteristic
Non-cicatricial/ non scarring alopecia
Exclamation mark sign
41
Clinical presentation of alopecia areata (4)
1. Single or multiple circumscribed smooth patchy hair loss
2. Most obviously on scalp, but frequently involving any hair bearing skin like beard, eyebrows, eye lashes.
3. Pathognomonic exclamation mark
4. “ Going gray overnight” phenomenon
42
Alopecia areata is rx by …..
DOC for herpes zoster
DOC for acyclovir resistant cases
Minoxidil
Acyclovir/ famciclovir
Foscarnet
43
Skin features of secondary syphilis (3)
1. Periostitis
2. Rashes
3. Moth eaten alopecia
44
Leprosy associated with …..cells
Rx of nerve abscess in leprosy
Virchow cells
I&D
45
Mc nerve involved in leprosy
Organs not involved in leprosy (4)
Ulnar nerve
1. Ovary
2. Lungs
3. CNS
4. Axilla
46
Mc type of leprosy in India
Lepromin test indicates ….
TT
Strong immunity
47
Define lucio phenomenon
Cutaneous ulcerations in patients with lepromatous leprosy
48
Features of lepromatous leprosy (3)
Gynecomastia
Madarosis
Collapse of nasal bridge
49
Histology of lepromatous leprosy
Dermis contains characteristic highly vacoulated cells -foam cells
50
Type 2 ENL reaction is …..hypersensitivity reaction. Rx.
Type 3
Thalidomide is effective
51
Type 1 hypersensitivity reaction is ……type of hypersensitivity reaction. Rx
Type 4
Corticosteroids
52
Light generated in wood’s lamp
Wood’s lamp filter is made of ……
360nm UV/ black light
Barium silicate glass containing 9% nickel oxide
53
Appearance of erythrasma in wood’s lamp is……
Lupus vulgaris is ……
Coral red colour
Skin TB with no underlying active focus
54
Tb of lymph node is called ….
Form of post primary TB with good resistance
Scrofuloderma
Tb verrucosa cutis -tb bacillus inoculated into skin.
Seen in TB patients, pathologists, veterinary surgeons
55
Skin diseases of staph aureus (3)
1. SSSS
2. Bullous impetigo/ impetigo contagiosa
3. Furuncles/boils
56
Reiters syndrome is secondary to ….(2)
1. Chlamydial infection- genital tract
2. Infectious dysentery -
Caused by : shigella
Salmonella
Ureaplasma urealyticum
57
Features of reiters syndrome (3)
1. Urethritis
2. Conjunctivitis
3. Arthritis - ascending asymetric oligoarthritis
58
Features of tuberous sclerosis (3)
1. Ash leaf spots
2. Adenoma sebaceum
3. Shagreen patches
59
Darriers sign seen in …
Pinch purpura seen in …..
Urticaria pigmentosa
Amyloidosis
60
Calcinosis cutis seen in …..
Crocodile skin seen in…..
Scleroderma
Ichthyosis
61
Iris pearls seen in ….
Asboe Hansen sign seen in ….
Leprosy
Pemphigus
62
Dubios sign seen in …..
Ollendroff sign seen in ….
Congenital syphillis
Secondary syphilis
63
Max joseph space seen in …..
Degeneration seen in lichen planus (3)
Lichen planus
Basal layer degeneration
Hyaline degeneration
Liquefactive degeneration
64
Pseudo-isomorphic phenomenon seen in ….(2)
1. Warts
2. Molluscum contagiosum
65
Pityriasis rosea is caused by ….organisms
Nail involvement in psoriasis is due to involvement of which structure
HHV6 & HHV7
Proximal nail matrix
66
Causative agent of scabies
Definitive diagnosis of sporotrichosis generally depends on …..labs
Sarcoptes scabeii
Culture and biopsy
67
Commonest site of atopic dermatitis
Antecubital fossa
68
Frie test is dx of ….
Most cutaneous eruption in SLE
LGV
Erythema of light exposed area
69
Which substance causes allergic contact dermatitis ?
Shagreen patch is usually found in which region
Parthenium
Lumbosacral
70
Melanocyte are present in which layer of skin
Dx of congenital syphilis is established by ….
Stratum basale
IgM FTA-ABS
71
Vagabonds disease is also known as …..
PUVA therapy is done in ….(2)
Pediculosis corporis
Psoriasis
Vitiligo
72
Painless ulcer with painless LAP suggests …..
Unnoticed painless papule with suppurative LAP s/o …..
Syphilis
LGV
73
Condition in which there is deposition of IgA in dermo-epidermal junction
Dermatitis herpetiformis
74
Use of thalidomide in leprosy
Oral drug (antibiotic) for management of acne
Type 2 lepra reaction
Doxycycline
75
Important Histological feature of tuberculoid leprosy
Pautriers microabscess is associated with …..
Non caseating granuloma
Mycosis fungoides
76
Otomycosis is caused by ..(2)
1. Aspergillus fumigatus
2. Candida
77
DOC for non-gonococcal urethritis
Leprosy does not affect which organ of females
Azithromycin
Uterus
78
Chronic familial benign pemphigus is also known as …..
Hailey hailey disease
79
……naevus may lead to melanoma
Mc type of basal cell carcinoma
Junctional
Nodulo ulcerative
80
Kerion in a …….infection
Layer of skin involved in acantholysis is ….
Fungal
Suprabasal/ intra-epidermal
81
Tzank smear finding in pemphigus
BPAG1 & BPAG2 & deposition of C3 & IgG at basement membrane suggest ….
Acantholytic cells
Bullous pemphigoid
82
Wavelength of carbon dioxide laser
Carpet tract sign is seen in ….
10600 nm
DLE
83
Lines of Blaschoko is present in …..
Duration of Rx for acrodermatitis enteropathica
Lines of development
Lifelong
84
Vitamin D is synthesized by which cells ….
Stain used to study fungal morphology in tissue sections
Keratinocytes
PAS
85
Angioedema is ……
Wavelength of UV beta rays
Edema of sc tissue
280 nm
86
Fordyce spots are ectopic ……
Flaky paint dermatosis is seen in …..
Sebacceous glands
Kwashiorkar
87
Koenen’s tumor is seen in ….
Which species of trichophyton is zoophilic?
Tuberous sclerosis
Tinea mentagrophytes
88
Id reaction is seen in …..
Molluscum sebaceum is another term for ….
Dermatophytes
Keratoacanthoma
89
Dimple’s sign is seen in ……
Dermatophytic LAD is seen in ……
Dermatofibroma
Mycosis fungoides
90
Felon is ….
Terminal pulp space infection
91
Cicatrizing alopecia with perifollicular blue gray patches is most common associated with …..
Whitish lesion in buccal mucosa
92
Earliest feature of tuberous sclerosis
Adenoma sebaceum in tuberous sclerosis is ……
Ash leaf spot
Angiofibroma
93
Scarring alopecia is seen in …..
Flag sign is seen in …..
DLE
PEM
94
Malignant pustule is …..
Rapidly spreading rodent ulcer
95
Mc organism causing tinea capitis
Most important investigation in diagnosing leprosy
Trichophyton tonsurans
Slit skin smear for AFB
96
A 7 year old child from Bihar is having hypopigmented anesthetic patch on his face. Most probable diagnosis
Intermediate leprosy
97
Slit skin smear is negative for which type of leprosy
Primary bullous lesion is seen in which type of syphilis
Neuritic leprosy
Congenital
98
Rx of choice in pustular psoriasis
Drug induced pemphigus is seen in ……drug (3)
Methotrexate
Penicillin
Captopril
Enalapril
99
Mouth lesions are seen in ….
Fordyce spots are …..
Lichen planus
Ectopic sebaceous glands
100
Acantholysis is seen in ……layer of skin
Discharging sinus is seen in …..
Epidermis
Actinomycosis
101
Gonorrhoea resistant structure is ……
Underlying internal malignancy is not shown by ……
Testis
Granuloma annulare
102
Skin disease not caused by staphylococcus
Skin biopsy in leprosy is characterized by ……
Erysipelas
Peri-appendigeal granulomatis
103
Not a lesion of leprosy
A 25 year old has palatal ulcers and skin blisters. Most likely dx is ……
Vesicle
Pemphigus vulgaris
104
Hydroquinone compounds cause depigmentation by their action on which enzyme
Circinate balanitis is seen in ….
Tyrosinase
Reiter’s syndrome
105
Cytoid bodies are found in …..
Norwegian scabies is causing by ……organism
Lichen planus
Female acarus scabiei
106
Vitamin D is synthesized by which cells of skin
Erythroderma is also known as ……
Prickle cells
Exfoliative dermatitis
107
2 year old child with reddish color on wood’s lamp
Congenital erythropoeitic porphyria
108
Thimble pitting of nails is seen in …..
Saw tooth rete ridges are seen in …..
Psoriasis
Lichen planus
