Pathology Flashcards

(202 cards)

1
Q

Dystrophic calcification occurs in ……tissues

Calcium level in dystrophic calcification is….

A

Dying tissues

Normal

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2
Q

What is red infarct? Where does it occur?

A

Venous occlusion seen in organ with dual blood supply

Gut

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3
Q

Mc type of necrosis

Features of irreversible injury (4)

A

Coagulative necrosis

  1. Flocculent,large amorphous densities in mitochondria —> increased mitochondrial permeability.
  2. Swelling and disruption of lysosomes and autolysis
  3. Nuclear degradation
  4. Plasma membrane damage
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4
Q

Features of apoptosis (3)

A
  1. Condensation of nuclear chromatin followed by fragmentation
  2. Formation of cytoplasmic/ membrane blebs
  3. Phagocytosis of apoptotic cells
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5
Q

Phagocytosis is inhibited by ….

Egs of autoimmune diseases (3)

A

Bcl2

  1. SLE
  2. Graves’ disease
  3. Myasthenia gravis
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6
Q

Gamma gandy bodies are seen in…..

A

Chronic venous congestion of spleen - sickle cell anemia

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7
Q

Leukotrienes which cause vasoconstrictions

LTB4 causes ….

A

LTC4,D4,E4

Adhesion of WBC

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8
Q

Prostaglandins inhibit…..in coagulation pathway

C5a is important in…..

A

Platelet aggregation

Chemotaxis

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9
Q

Wound contraction is mediated by …..

Epitheloid and multinucleated giant cells are derived from ….

A

Fibroblast

Monocyte-macrophages

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10
Q

ARDS/ diffuse alveolar damage is also known as….

Lines of Zahn are seen in ……

A

Shock lung

Thrombus

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11
Q

Chicken fat clot is ….

Procoagulant states (2)

A

Post mortem thrombus

  1. Protein C & S deficiency
  2. Factor 5/ Leiden mutation
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12
Q

Hyperviscosity seen in …(2)

A

Cryoglobinemia
Multiple myeloma

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13
Q

MHC is located on chromosome…..

Cells that are a part of innate immunity

A

6

NK cells

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14
Q

NK cells are expressed on …..

NK cells kills …..&…….cells

A

CD16,CD 56

Infected and cancer cells

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15
Q

Killing by NK cells is …..

A

MHC independent-not dependent on foreign Ag presentation

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16
Q

Translocations for burkitt lymphoma (2)

A

t(8:14), t(8:22)

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17
Q

Translocation for CML
Ewing sarcoma

A

t(9:22)

t(11:22)

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18
Q

Tumor marker for
1. Endodermal sinus tumor
2. Yolk sac tumor

  1. Pancreatic Neuroendocrine tumor
  2. Ca cervix
A
  1. AFP
  2. AFP
  3. Gastrin
  4. Keratin
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19
Q

Hypersensitivity reaction of PK/ prusnitz reaction

Casoni’s test

A

Type 1

Type 1

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20
Q

Hypersensitivity for schick’s test

A

Type 3- immune complex mediated

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21
Q

Egs of type 2 hypersensitivity reactions (5)

A
  1. ITP
  2. Immune haemolytic anemia
  3. Blood transfusion reaction
  4. Good pasteurs syndrome
  5. Graves’ disease (type 5)
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22
Q

Light microscopy of amyloidosis

A

Enlarged tubular basement membrane

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23
Q

Common types of amyloidosis (3)

A

Systemic
Localised
Hereditary

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24
Q

Types of systemic amyloidosis (3).

A
  1. Primary amyloidosis
  2. Secondary amyloidosis
  3. Dialysis related amyloidosis
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25
Types of localised amyloidosis (5)
1. Alzheimer’s disease 2. Type 2 DM 3. Medullary carcinoma thyroid 4. Isolated atrial amyloidosis 5. Systemic senile amyloidosis
26
Types of hereditary amyloidosis (2)
1. Familial amyloid cardiomyopathy 2. Familial amyloid polyneuropathy
27
Fibril protein of primary amyloidosis and seen in …..
AL Ig light chains Seen in multiple myeloma
28
Fibril protein of secondary amyloidosis and seen in ….(4)
Serum amyloid A (AA) Seen in chronic If conditions: 1. IBD 2. Familial Mediterranean fever 3. Rheumatic arthritis 4. Protracted infection
29
Fibril protein in dialysis related amyloidosis Fibril protein of Alzheimer’s disease and pathology
Beta 2 microglobin B amyloid protein Cleaved amyloid precursor protein (APP)
30
Fibril protein of type 2 DM and pathology
Islet amyloid polypeptide Caused by deposition of amylin in pancreatic islets
31
Fibril protein in Medullary carcinoma thyroid Protein in isolated atrial amyloidosis Seen in ….. risk of ….
Calcitonin ANP Seen in normal aging Increased risk of Atrial fibrillation
32
Amyloid protein deposited in systemic senile amyloidosis Seen predominantly in …..
Normal Wild type transthyretin TTR Cardiac ventricles
33
Mutated transthyretin gene is seen for ….(2)
1. Familial amyloid cardiomyopathy 2. Familial amyloid polyneuropathy
34
Manifestations of amyloidosis (6)
1. Cardiac: Restrictive cardiomyopathy 2. G.I: macroglossia, hepatomegaly 3. Renal : nephrotic syndrome 4. Hematology: easy bruising, splenomegaly 5. Neurology: neuropathy 6. MSK : Carpal tunnel syndrome
35
5% African Americans are carriers of …..amyloidosis
Familial amyloid cardiomyopathy
36
Most common site of amyloidosis Best dx method for amyloidosis
Kidney —-> Liver Abdominal fat biopsy > Rectal biopsy
37
Congo red stain in ordinary light gives … Expression of homocysteinuria
Pink colour Autosomal recessive
38
Expression of VWD Expression of retinoblastoma
AD AD
39
Expression of hereditary spherocytosis Chromosome 3 is involved in …. Chromosome 4 is involved in …..
AD Renal cell carcinoma Huntington’s chorea
40
Chromosome 7 is involved in ….. Gene for folate carrier protein is located on ….
Cystic fibrosis Chromosome 21
41
Gene regulating morphogenesis APC is located on …. BRCA1 is located on … BRCA2 is located on ….
Homeobox genes (HOX) Chromosome 5 Chromosome 17 Chromosome 13
42
First Ab to be synthesised after exposure to new Ag First ab to be synthetized by fetus Ab that fixes complement
IgM IgM IgM
43
Ig mediating reaginic hypersensitivity IFN alpha is produced by ….. IFN beta is produced by ….
IgE Leukocytes Fibroblasts
44
IFN produced by T lymphocytes and NK cells Edward syndrome is trisomy …. Patau syndrome is trisomy ….
IFN gamma 18 13
45
Complement for opsonisation Complement for chemotaxis
C3 b C5 a
46
Most abundant collagen of human body is …. Gene for von hipple lindau disease
Type 1 VHL gene - tumour suppressor
47
Rb gene is a tumour suppressor for …(2)
Retinoblastoma Osteosarcoma
48
BRCA is tumour suppressor for …. Medium sized vessels arteritis includes (2)
Hereditary breast carcinoma PAN Kawasaki disease
49
Esr of 100 is seen in …. Pathological feature of malignant hypertension
Temporal arteritis Fibrinoid necrosis
50
Hyaline arteriosclerosis is seen in …. Pseudo aneurysm/ false aneurysm is seen in ….
Benign HTN Hematoma - does not contain all 3 layers of arterial wall
51
Valves least involved in RHD Earliest change seen in MI
Tricuspid valve & pulmonary Waviness of fibers
52
Change noticed within 1-3 days of MI Scarring in MI is complete by …..
Granulation tissue 3 months
53
Charcot layden crystals are seen in ….. Curschmann spirals are seen in ….
Asthma Asthma
54
Test used for sarcoidosis Features of sarcoidosis (3)
Kveims test 1. End stage lung disease in 15-30% cases 60-70% recovers 2. Non caseating sarcoid granuloma 3. Does not involve brain
55
Condition which may mimic sarcoidosis Egg shell calcification pattern seen in …. Intense fibrosis is a pathological feature of ….
Berylium inhalation Silicosis Mesothelioma
56
Particle size dangerous for pneumoconiosis
Smaller than 1 micron
57
Squamous cell esophageal cancer is related to ….(5)
1. Smoking 2. Alcohol 3. Chronic achalasia 4. Plummer Vinson syndrome 5. Tylosis
58
Virus causing esophagitis (3)
1. HSV1 & 2 2. Varicella zoster 3. CMV
59
GIST/ gastrointestinal stromal tumors are expressed on …(2)
CD117 & CD 34
60
Features of Gardner syndrome (4)
1. Rectal and colonic polyposis 2. Skin cysts 3. Osteomas 4. Dentigerous cysts
61
Features of peutz jegherz syndrome (2)
1. Hamartomatous polyps of GIT 2. Mucocutaneous pigmentation
62
Features of von recklinghausen disease (2)
Generalised neurofibromatosis Cafe au lait pigmentation
63
Genetic predisposition for celiac disease (2)
DQ2,DQ8
64
Typhoid ulcers are (3)
1. Longitudinal 2. Ulceration of peyers patches 3. Stricture is rare
65
Pipe stem colon is seen in….disease Mc site of involvement in Crohn’s disease
Ulcerative colitis Ileum
66
Mallory bodies are composed of … Mallory bodies are seen in….(2)
Eosinophilic intracytoplasmic inclusions 1. Primary biliary cirrhosis 2. Alcoholism
67
Mallory hyaline is absent in ..(2)
1. Secondary biliary cirrhosis 2. Hepatitis
68
Acute infection of HBV ….positive (2) Mc cause of sporadic cases of hepatitis in adults
1. HbsAg+ 2. IgM antiHBc + HEV
69
Angiosarcoma of liver is associated with …(2)
1. Vinyl chloride 2. Aflatoxin
70
Flea bitten kidney is seen in …(2)
1. Malignant HTN 2. Acute PSGN
71
Contracted kidney is seen in ..(2)
1. Chronic GN 2. Chronic pyelonephritis
72
AntiGBM ab seen in ….disease Diffuse involvement is seen in ….
Goodpasteurs syndrome PSGN
73
Sub epithelial humps seen in …. FSGN having worst prognosis…..
PSGN Collapsing variety
74
Subepithelial spikes is a feature of … What are the crescents in RPGN?
Membranous GN Epithelial cells+ fibrin + macrophage
75
Alports syndrome features (3)
1. Hereditary nephritis 2. Nerve deafness 3. Eye disorders : anterior lenticonus Dot and fleck retinopathy
76
Lung involvement in wegeners granulomatosis
B/L modular cavitary infiltrates- showing necrotising granulomatous vasculitis
77
Renal biopsy in wegeners granulomatosis is that of …..
Pauciimmune necrotising and crescentic GN
78
B/L renal cell cancer may be seen in ….. Finnish type of nephritic syndrome is due to ……
Von Hippel Lindau disease Mutation of nephron
79
Mc gene defect in steroid resistant nephritic syndrome is ….. Papillary thyroid cancer spread by ….
NPHS2 Lymphatics
80
Histology feature of papillary thyroid cancer Hurthle cell cancer is a variant of ….
Orphan annie eyed nuclei Follicular cancer of thyroid
81
Helmet cells are seen in ….(2)
1. HUS 2. Coombs positive
82
Bite cells are seen in …. Schistocytes are seen in …..
G6PD Acquired spherocytosis
83
Ring sideroblasts are ….
Iron granules in mitochondria around nucleus
84
Tear drop poikilocytosis seen in …(2)
1. Myeloid metaplasia 2. Myelofibrosis
85
Post splenectomy histology changes includes (2)
1. Howell Jolly bodies 2. Heinz bodies
86
Burr cells are seen in …. Acanthocytes are seen in ….
Uraemia Chronic liver disease Post splenectomy
87
Spur cells are seen in ….. Sickle cell anemia causes ….
Chronic liver disease Structurally abnormal Hb
88
Basically hereditary spherocytosis is a …. Proteins defective in HS (3)
Cell membranes defect Ankyrin Paladin Anion transport protein
89
Causes of aplastic anemia (2)
1. Drugs: chloramphenicol 2. Virus
90
Feature absent in aplastic anaemia Most effective treatment of aplastic anemia is ….
Splenomegaly Bone marrow transplant
91
Conditions associated with AML (2) Features of AML (2)
Down’s syndrome Bloom syndrome Chloroma Auer rods
92
AML subtype which is not positive for nonspecific esterase AML with gum infiltration
M6 M4
93
Acute promyelocytic leukemia is associated with …. Translocation is …..
DIC t( 15:17)
94
B cell neoplasms include (2)
1. Hairy cell leukaemia 2. Mantle cell lymphoma
95
Histology of multiple myeloma (2) Labs of MM (2)
Russel bodies and flame cells Urea level raised Bence jones proteins
96
Associated feature of hairy cell leukaemia DOC of hairy cell leukaemia
Splenomegaly Cladribine
97
Malignant cells of Hogkins lymphoma are… RS cells are positive for ….(2)
RS cells 1. CD15, CD 30
98
Subtype of hogkins lymphoma which is not postive for CD15,CD 30. Hogkins lymphoma with hilar LAD
Lymphocytic predominance Nodular sclerosis
99
Mc type of Hogkins lymphoma Mc type of Hogkins lymphoma in India
Nodular sclerosis Mixed cellularity
100
Mc site of extranodal non-Hogkins lymphoma Starry sky appearance is seen in ….
Stomach Burkitt’s lymphoma
101
Features of anti phospholipid antibody syndrome (2)
1. Arterial / venous thrombosis 2. Recurrent fetal loss 2nd trimester
102
Lab findings of anti phospholipid antibody syndrome (2)
Prolonged APTT Normal PT
103
Complex granular corpuscles are produced by ….. CSF findings of pyogenic meningitis (2)
Microglia 1. Increased protein 2. Decreased sugar
104
Mc primary brain tumour Mc brain tumour in adults Mc posterior fossa Tumor in children:
Glioma Secondaries Cerebellar (pilocytic) astrocytoma
105
Pseudo-rosette is seen in …..(2) Enamel like structure is found in ….. Glial fibrillary proteins are seen in ….
Neuroblastoma Retinoblastoma Craniopharyngioma Astrocytoma
106
Mc site of berry aneurysm Histology of Alzheimer’s disease (2) Pick bodies are seen in ….
Anterior circle of willis Hirano bodies Neurofibrillary tangles Pick disease
107
Mc B/L breast tumour Mc tumors of ovary
Lobular cancer Primary epithelial tumors ( cystadenoma, clear cell cancer)
108
Reinke’s crystals are seen in …. Conditions associated with germ cell tumours of testes (2)
Hilus cell tumour Cryptoorchidism Testicular feminization syndrome
109
GCT associated with klinefilters syndrome Seminoma corresponds to …..
Medullary GCT Dysgerminoma of ovary
110
Window period of HIV
Time between infection and detection of ab of HIV
111
Hallmark of HIV (2)
1. Profound immunodeficiency 2. Quantitative and qualitative deficicency of helper or inducer T cells
112
AIDS related neoplasm (3)
1. Kaposi sarcoma 2. B cell NonHogkin lymphoma 3. Primary lymphoma of brain
113
Kaposi sarcoma arises from ….. Kapoks sarcoma is associated with (2)
Blood vessels HIV Immunosuppression/organ transplant
114
HLA A3 is associated with ….. HLA B8 is associated with ….
Hemochromatosis Addisons disease Myasthenia Gravis Graves’ disease
115
HLAB27 is associated with
PAIR Psoriatic arthritis Ankylosing spondylitis IBD arthritis Reactive arthritis
116
HLA associated with psoriasis
C
117
HLA Dr2 is associated with (4)
Multiple sclerosis Hay fever SLE Good Pasteur syndrome
118
Hashimotos thyroiditis is associated with HLA… Addisons disease is associated with HLA
DR 3,5 B8,DR3,4
119
conditions of DR 3 (4)
SLE DM type 1 Hashimotoz Addisons
120
Conditions of DR 4 with HLA (3)
Rheumatoid arthritis DM type 1 Addisons disease
121
Pathology of coagulation necrosis
Arterial obstruction - type of cell necrosis dealing with obstruction/slow blood flow- leading to ischemia
122
Malignancy of breast is likely to be associated with which type of microscopic appearance of breast tissue Mc tumor of appendix
Atypical epithelial hyperplasia Argentaffinoma
123
Infective endocarditis is not seen with which heart condition Wilms Tumor gene is located on chromosome….
ASD Chromosome 11
124
Feature of adult CML but not juvenile CML Intracranial tumor having good prognosis in children
Philadelphia chromosome is positive Cerebellar astrocytoma
125
Sustained severe HTN in children is most common suggestive of ….. Mc posterior mediastinal tumor is ….
Renal parenchymatous disease Neurofibroma
126
Characteristic feature of kidney in DM
Diffuse glomerulosclerosis
127
Irreversible cell injury is demonstrated by Poorly differentiated carcinoma expresses which tumour marker
Amorphous large densities in mitochondria Cytokeratin
128
Marker of small cell carcinoma of lung Cause of Edema in nephritic syndrome
Chromogranin Salt and water retention
129
Klatskin tumor is another term for …. Burkitts lymphoma is positive for Cd…
Cholangiocarcinoma CD 19
130
HMB45 is used as a marker for … Creola bodies are seen in …
Malignant melanoma Asthma
131
Lardaceous spleen is seen in …. Transverse ulcers in GIT are seen in which infection …
Amyloidosis TB
132
Pulmonary artery is not involved in ……vasculitis Loss of intercellular connections between cells is known as ….
Churg Strauss syndrome Acantholysis
133
Duchenne muscular dystrophy is a ……protein defect Takayasu arteritis does not affect which arteries
Sarcolemmal Coronary artery
134
Pneumoconiosis as a result of prolonged cotton dust inhalation Necrotising papillitis is seen in ….(3)
Bysinnosis DM Sickle cell anemia Analgesic nephropathy
135
Oral hairy leukoplakia is caused by ….virus Antihistone Ab are associated with ….
EBV Drug induced lupus
136
Histology of measles Stain for reticulocytes
Warthin Finkeledy cells Brilliant cresyl blue
137
Endoscopes are sterilised by …. Biological transmission shown by filariasis
2% glutaraldehyde Cyclodevelopmental
138
Procalcitonin ( amyloid protein) is associated with ….. Acanthocytes in peripheral smear are seen in ….
Medullary carcinoma of thyroid Abetalipoproteinemia
139
Mc type of acute bacterial endocarditis Herring bodies are seen in ….
Staph aureus Neurohypophysis Herring bodies are Neurosecretory vesicles where oxytocin and ADH are released prior to release.
140
Mc site of left atrial myxoma Fibrous plaques are composed of ….
Fossa ovalis Smooth muscle cells, fibrous tissue
141
Fibrous cap in atheroma contains… Storage organelles in von willibrand factor found in endothelial cells
Smooth muscle cells and collagen Weibel Palade bodies
142
Subungual fibromas are seen in … Stain used to identify viable myocardium in myocardial injury
Psoriasis TTC- triphenyl tetrazolium chloride
143
Amyloid tissue produces mahogany brown stain with …. Amyloid produces apple green birefringence due to ….
Iodide and sulphuric acid Cross beta pleated configuration of amyloid fibrils
144
Myelin figures are formed during ….. Hutchinson’s secondaries in skull are due to tumours of which gland?
Necrosis Adrenal
145
Mc site of gastrinoma in werner syndrome Least common cause of calcification in lung is ….
Small intestine Amyloidosis
146
Hypersensitivity vasculitis is seen in which part of vascular system Which factor is responsible for cardiac hypwrtrophy?
Post capillary venules C-myc
147
Features of silicosis on cut section of lung (2)
Palpable nodules in early stages Hard collagenous scar in late stages with pleural thickening
148
Earliest feature of TB is proliferation of …. Asteroid bodies are seen in ….
Lymphocytes Sarcoidosis
149
Metastatic calcification most often seen in … Pneumonia alba caused by ….
Lungs Treponema pallidum
150
APUD cells are seen in which tumour of lung Content of Mallory hyaline (2)
Bronchial carcinoid Cytoskeleton intermediate filaments Prekeratin
151
Gall bladder thickening with comet tail on USG s/o ….
Adenomyomatosis of gall bladder
152
Marrow in iron deficiency anemia (2)
1. Normoblastic 2. Deficient reticuloendothelial iron stores
153
Tissue thromboplastin activates which factor Increased PT and normal PTT are seen in deficiency of which clotting factor
Factor 7 Factor 7
154
Addition of glucose to stored blood prevent … Periglomerular fibrosis is considered typical of ….
Hemolysis Chronic pyelonephritis Any chronic renal diseases- periglomerular fibrosis is fibrosis of glomeruli due to lack of blood supply.
155
Increased C3NF associated with which glomerulonephritis Onion peel appearance of splenic capsule is seen in ….
MPGN2 SLE
156
Systemic miliary TB occurs when spread of infection occurs through which route Regeneration of liver after partial hepatectomy is an eg of ….
Arterial Hyperplasia
157
Optic nerve meningioma arises from which meninges Mc primary malignant bone tumor is ….
Arachnoid Multiple myeloma
158
Rb gene is located on which chromosome Eg of transcription factor
Chromosome 13q14 MYC
159
Mx inheritance of retinitis pigmentosa Leptocyte in blood smear are seen in ….
Sporadic Thalassemia
160
CD marker for MALT lymphoma Staining used in dx in Hirschsprung disease
CD 20 AchE
161
Immune mediated complexes is which type of necrosis Ann Arbor classification is used for ….
Fibrinoid necrosis Hogkins lymphoma
162
Donath Landsteiner test is used in dx of ….
Paroxysmal cold hemoglobinuria
163
Characteristic of whipples disease Characteric labs of FSGN (2)
Foamy macrophage IgM , C3
164
In type 1A maple syrup urine disease, gene mutation is seen in …. Dent disease is due to defect of ….
E1a Chlorine channel
165
Cyclin D and IGH fusion gene is associated with …. Mc cause subtype of hepatitis B in north India
Mantle cell carcinoma ayw
166
Isolated rise in aPTT is seen in …. Harlequin icthyosis is inherited as ….
Antiphospholipid Ab AR
167
Multifactorial inheritance is most likely to result in …..disorder HLA marker of Behçet’s disease
Cleft lip B51
168
CD marker of langerhans histiocytosis In which disease is IL-6 persistently raised
CD 1 a Behçet’s disease
169
Burkitt lymphoma is positive for CD …. Which gene is responsible for mutation in hepatitis B virus ?
CD 20 C gene
170
Use of cryoprecipitate Mutation in Gs-alpha may lead to which disease
Afibrinogenemia Mc cune Albright syndrome
171
Pseudo-pelger huet cells are found in… Mc encountered mutation in carcinoma prostrate
Myelodysplastic syndrome GPST 1
172
Which substance leads to resolution of Inflammation? (3)
1. TNF alpha 2. IL-10 3. IL-1 receptor antagonist
173
Necrotising arteriolitis with fibrinoid necrosis is found in …. Cystic medial necrosis with necrotising arteritis is found in ….
Ag-ab mediated Aortoarteritis
174
Anemia with reticulocytosis is seen in …. Carcinoid heart disease affects which part of heart
Haemorrhage Valvular endothelium
175
In atherosclerosis, foamy cells contain lipid in the form of …. Cellular infiltrates seen in late pseudomonas infection
Oxidized LDL Neutrophils
176
Mc site for adenoid cystic carcinoma Which tumor has consistency and appearance of grape like cluster ?
Minor salivary glands Embryonal rhabdomyosarcoma
177
Characteristic peripheral blood picture in megaloblastic anemia (2) Dx of falciparum malaria is made by ….
Macrocytosis Decreased reticulocyte count PfHRP-2
178
Enzyme alpha-naphthyl esterase is present in ……cell Primary membranous Nephropathy has antibodies against ……
Monocyte Phospholipase A2
179
TNF and IL-1 are produced by …… EBV receptor located on surface of B cell is …..CD
Activated macrophages CD 21
180
Increased prothrombin time results from deficiency of which molecule Thymic hypoplasia is associated with which syndrome
Fibrinogen Myasthenia Gravis
181
Cleft like space in atheromatous plaque contains ….. Characteristic histopathology finding in whipped disease (2)
Cholesterol crystal 1. PAS positive macrophages 2. Rod shaped bacilli in lamina propria
182
Mc cause of inherited peripheral neuropathy Flow cytometry is done to know….
Charcot Marie tooth disease Rapid cell shrinkage
183
Sequence of events in acute inflammation
Transient vasoconstriction —-> vasodilation—->increased permiability—->stasis
184
Mc part of body involved in multiple myeloma Absence of lamina dura is seen in …….
Bone marrow Hyperparathyroidism
185
Mc cause of iodine deficiency in India Diabetic foot ulcer is commonly associated with ……
Autoimmune hypothyroidism Microangiopathy
186
Most specific marker for gastrointestinal stromal tumor Apoptosis is directly regulated by …..
CD117 Cytochrome C
187
Aneuploidy is due to …… Dystrophic calcification is seen in ……
Nondisjunction at meiosis Atheromatous plaques
188
Feature of COPD Not a component of Werner’s syndrome
Amyloidosis Adrenals
189
Malignancy in pheochromocytoma is indicated by …. An autosomal dominant condition is ……
Metastasis Huntingtons chorea
190
Mc premalignant condition of oral carcinoma Benzene therapy causes ….
Leukoplakia AML
191
An important factor for chronic pyelonephritis is …… Hormone Not a cause of increased capillary permeability
VUR Renin
192
False for renal amyloidosis
Renal amyloidosis commonly presents with HTN
193
Protein not decreased in nephrotic syndrome Property of protective epithelium
Fibrinogen Regenerative power
194
Cyclic changes in women breast consists of …. Dx feature of rheumatic heart disease
Epithelial cell proliferation Aschoff bodies
195
Most commonly defective antibody in multiple myeloma Most common organ associated with poly cystic disease
IgG Liver
196
In which condition, ubiquitin gets deposited in neurons Residual body is defined as …..
Huntingtons chorea Lysosome with undigested particle inside
197
FLIP is which type of gene Type of necrosis seen in omentum
Antiapoptotic Fat necrosis
198
Which type of amyloid protein is raised in ankylosing spondylitis HLA associated with paoriasis vulgaris
Serum amyloid associated protein HLA Cw6
199
Most prominent cells in rheumatic arthritis A 55 year male presented with dry mouth and rheumatoid arthritis, Dx with minor salivary gland tumour. Earliest histological finding is …..
Lymphocytes Lymphocyte
200
Most common epithelial stomach tumor is …. Underlying process of TB
Adenocarcinoma Hypersensitivity reaction with modified macrophages,lymphocytes, and giant cells
201
A 55 year old smoker underwent mass resection from bronchus. Most useful immunohistochemical marker to make proper dx is ….. Bio marker for follow up of granulosa cell tumour of ovary
Cytokeratin Inhibin
202
Increase in bleeding time seen in ….
VWD