Pharmacology Flashcards
(246 cards)
1
Q
Define pharmacokinetics
A
Study of drug movement in the body/ effect of body on the drug
2
Q
Define side effects
A
Unwanted effects of the therapeutic doses
3
Q
Define agonist vs antagonist
A
Agonist: have affinity and maximal efficacy
Antagonist: have affinity and no maximal efficacy
4
Q
Define clearance
A
Measure of the body’s ability to excrete the drug
5
Q
Optimal effect exerted over narrow range of plasma drug concentration is …..
A
Therapeutic window phenomenon
6
Q
Define drug efficacy vs drug potency
A
Drug efficacy: maximal effect that a drug may elicit
Drug potency : amount of drug required to produce a certain response
7
Q
Define bioavailability
A
Fraction of the drug that reaches the blood.
8
Q
Microsomal enzyme inducers (3)
A
Phenytoin
Phenobarbitone
Rifampicin
9
Q
Drugs showing high first pass metabolism are (3)
A
Lignocaine
Propranolol
Salbutamol
10
Q
Define first pass elimination
A
Metabolism of drug in liver,intestine/portal blood. + Excretion of drug into bile
11
Q
T1/2 can determine (4)
A
Elimination time
Steady state plasma conc
Dosing rate
Maintainance dose
12
Q
Egs of prodrugs (4)
A
Enalapril
Sulindac
Ticlopidine
Clopidogrel
13
Q
Difference between zero order and first order kinetics
A
Zero order First order
1. Constant amount Constant fraction
2. t1/2 variable t1/2 constant
3. Rate of elimination Rate of elimination
independent dependent
14
Q
Phases of clinical trials and it’s determination
A
Phase 1: Human pharmacology & safety
Phase 2: Efficacy, dose ranging.
Phase 3: therapeutic confirming
Phase 4: post marketing surveillance
15
Q
Drugs causing osteoporosis (2)
A
- Steroid
- Heparin
16
Q
Drugs with low safety margin (3)
A
Lithium
Aminoglycosides
Digoxin
17
Q
Drugs causing hirsuitism (2)
A
Minoxidil
Phenytoin
18
Q
Drugs causing extra pyramidal side effects (2)
A
Haloperidol
Levodopa
19
Q
Hemolysis in G6PD deficiency caused by …(4)
A
Dapsone
Primaquine
Sulfonamides
Nitrofurantoin
20
Q
Drug deposited in retina
Drug deposited in muscle
A
Chloroquine
Digoxin
21
Q
Drugs causing hepatitis (4)
A
Halothane
Rifampin
INH
Pyrazinamide
22
Q
Drugs causing intrahepatic cholestasis (2)
A
Phenothiazines
TCA
23
Q
Egs of hepatotoxins (2)
A
CCL4
Paracetamol
24
Q
Drug metabolised in liver (4)
A
Phenytoin
Erythromycin
Cimetidine
Diazepam
25
Drug metabolised in kidney
Penicillin G
26
Duration of action of a drug administered iv depends upon (5)
1. Protein binding
2. Clearance
3. Distribution volume
4. Lipid solubility
5. Drug concentration
27
Effect of displacement of protein bound drug
Raises plasma level of that drug
28
Drug binding sites on protein are :
Non-specific- one drug can displace the other
29
Drugs bound to albumin (2)
Phenytoin
Warfarin
30
Phase 2 of drug metabolism involves (3)
Conjugation with glucoronide, sulfate, glutathione
31
Ach as a molecule can’t be used because
Uses of neostigmine/pyridostigmine (3)
It is rapidly degraded
Urinary retention
Ileus
Reversal of Nm blockade
32
Pupil in organophosphate poisoning
Rx for organophosphate poisoning
Pin point
Atropine + pralidoxime
33
Use of atropine (3)
1. Rx of bradyarrhythmias
2. Early mushroom poisoning
3. Organophosphate poisoning
34
Alpha 1 agonist egs (2)
Phenylephrine
Methoxamine
35
Alpha 2 blockers
Yohimbine
Mirtazapine
36
Egs of beta agonists
Isoproteronol ( beta 1= beta 2)
Dobutamine (beta 1> beta 2)
37
Egs of beta 2 agonist (3)
1. Salmeterol
2. Terbutaline
3. Ritodrine
38
Timolol is c/i for …..(2)
Heart block
Asthma
39
Shortest acting beta blocker
Esmolol
40
Egs of 5HT 1 A and 5HT 1 B agonist
5HT 1A agonist : Buspirone
5HT 1B agonist : sumatriptan
41
Eg of 5HT 4 agonist.
Egs of 5 HT 2A antagonist (2)
Cisapride
Cyproheptadine
Ketanserin
42
Egs of 5HT 2A/2C antagonist
Egs of 5HT 3 antagonist
Clozapine
Ondansetron
43
2 roles of PG
Cytoprotective for stomach
Contract uterus
44
Rx for NSAID induced ulcer
Thromboxane is a …….
Misoprostol
Platelet aggregator
45
Uses of alprostadil (2)
PGE1
Causes vasodilation
Useful in erectile dysfunction
46
Uses of dinoprostone (3)
PGE 2
Contraction of uterus
Abortificant
Cervical ripening
47
Eg of irreversible COX inhibitor
Egs of selective COX 2 inhibitor
They lack ……
Aspirin
Lumiracoxib
Valdecoxib
They lack anti platelet action
48
Nimesulide and diclofenac are …..COX inhibitors
Preferential COX 2 inhibitor
49
NSAID with good tissue perfusion
NSAID with good conc in synovial fluid
Ketorolac
Diclofenac
50
Non narcotic non steroidal drug is ….
Acts on ….
Ketorolac
Opioid receptors
51
Indapamide is a …….drug
Side effects of the above . (2)
Thiazide diuretic drug
Hyperglycaemia
Hypercalcemia
52
Important feature of thiazides
Used in rx of hypercalciuria, but they themselves cause hypercalcemia and renal calculi
53
Furosemide is a …….derivative
Side effects of furosemide (3)
Sulfamoyl derivative
1. Hyperuricemia
2. Hypocalcemia
3. Hyperlipidemia
54
Spironolactone antagonises ……
Sodium retaining effect of aldosterone
55
Active metabolite of spironolactone is …..
Caneronone
56
MOA of mannitol
Increases ECF and renal blood flow especially to medulla
57
C/I of mannitol (3)
1. Acute tubular necrosis
2. Anuria
3. Pulmonary Edema
58
Effect of metformin on glucose metabolism (2)
1. Increased glycolysis
2. Decrease gluconeogenesis
59
Special feature of metformin (2)
Does not cause weight gain, hence used in obesity
Obesity is not a c/I
60
Egs of alpha glucosidase inhibitor (2)
Acarbose
Miglitol
61
MOA of Acarbose , miglitol (2)
1. Reduces fibrinogen level
2. Decrease progression of impaired glucose tolerance to overt disease
62
Special feature of Acarbose,miglitol
Do not cause hypoglycemia
63
Features of tolbutamide (3)
It’s a sulfonylureas
Causes hypoglycemia that is
Severe
Prolonged for days
Fatal - elderly and heart failure
64
Effect of pioglitazone (2)
Acts by binding to PPARS
Increases insulin sensitivity
65
t1/2 of insulin
Difference of human and pork insulin
5 minutes
Differs by 1 amino acid
66
Humulin is ……
Human insulin
67
Max mineralocorticoid activity shown by ….
Max glucocorticoid activity shown by ….
1. Aldosterone
2. Dexamethasone
68
Androgen receptor blocker:
Anti-estrogen drug
Cyproterone
Clomiphene
69
Tamoxifen decreases……
Agents used for ca breast (3)
FSH
1. Tamoxifen
2. Exemastine
3. Letrozole
70
S/E of danazol (3)
1. Acne
2. Weight gain
3. Occasionally hot flashes
71
Flutamide and nilutamide are …..
Use of flutamide
Antiandrogens
Metastatic prostate cancer along with GNRH analogues
72
MOA of theophylline and doxofylline (5)
1. Inhibit PDE4
2. Increase CAMP conc
3. Blocks adenosine receptors
4. Beta 2 agonist
5. Stimulator of mucociliary movement
73
Factors decreasing theophylline levels (2)
1. Smoking
2. Enzyme inducers
74
Factors increasing plasma levels of theophylline (3)
1. Erythromycin
2. Ciprofloxacin
3. Cimetidine
75
MOA of monteleukast (2)
1. CysLT1 receptor antagonist
2. Blocks action of leukotriene D4 on cysLT1 receptor in lungs
76
Uses of monteleukast (3)
1. Used in maintenance therapy of asthma
2. Relief of seasonal allergies
3. Not used in acute attacks
77
Steroid in asthma
Act by ….(3)
No role in acute attacks/ status asthmaticus
1. Anti I.F / reduce airway I.F
2. Increase lipocortin levels
3. Blocks phospholipid breakdown
78
Commonly used steroids in asthma (3)
1. Budesonide
2. Triamcinolone
3. Fluticasone
79
S/E of parenteral steroid
Zafirlukast is taken …..
Posterior subcapsular cataract
Once daily
80
Egs of anticholinergic bronchodilators (2)
Ipratropium
Tiotropium
81
Drugs which inhibit cross linking (transpeptidases) and impair cell wall synthesis (5)
1. Penicillin
2. Cephalosporins
3. Vancomycin
4. Imipenem
5. Aztreonam
82
Drugs binding to 30S ribosomal units and inhibiting protein synthesis (2)
1. Streptomycin
2. Tetracycline
83
MOA of trimethoprim
Inhibit nucleotide synthesis of tetrahydrofolate
84
Penicillinase resistant drug is ….(2)
Methicillin (acid labile )
Cloxacillin
85
Quinupristin/dalfopristin are ……
(Bactericidal/bacteriostatic)
Used in …..
Bacteriostatic
Vancomycin resistant enterococcus fecalis
86
Imipenem is inhibited by ……
Dihydropeptidase
87
Special feature of aztreonam
Can be safely given to patients allergic to penicillin and related group of drugs - coz they lack cross reactivity
88
Egs of glycopeptide antibiotics (2)
Vancomycin
Teicoplanin
89
S/E of vancomycin
DOC for MRSA infection
Red man syndrome
Metronidazole 1st
Vancomycin 2nd
90
Drug used to rx pseudomembranous colitis
Cefoperazone has ……activity
Vancomycin
Antipseudomonal activity
91
Azithromycin is effective against (4)
1. Chlamydia
2. Mycoplasma
3. Ureaplasma
4. Legionella
92
Macrolides cause GIT distress why?
Drug used for penicillin allergies
Coz they stimulate motilin receptors
Erythromycin
93
Complications arising from outdated tetracycline
S/E of doxycycline
Fanconi’s syndrome
Photodermatitis
94
Tetracycline causing hyperpigmentation
Minocycline
95
S/E of tetracycline (3)
1. Teratogenic
2. Superinfection
3. Tooth discoloration
96
MOA of chloramphenicol
MOA of clindamycin
Bind to 50S subunit
Block elongation of peptide chain
Bind to 50S subunit and inhibit protein synthesis
97
MOA of aminoglycosides (3)
1. Inhibit translation
2. Bactericidal
3. Distribution only extracellular
98
Streptomycin is used in …..
S/E of aminoglycosides
Plague/tularemia
1. Teratogenic
2. Ototoxic
3. Vestibulotoxic
4. Nephrotoxic
5. Causes Nm blockage- should not be used for rx of myasthenia gravis
99
Framycetin, sisomycin belong to …
One of the most resistant aminoglycosides to bacterial inactivating enzyme is ….
Aminoglycosides
Amikacin
100
Longest acting quinolone is …..
Most phototoxic quinolone is ….
Sparfloxacin
Sparfloxacin
101
Quinolone should be avoided in …..
Children -causes arthropathy
102
1. DOC in cholera
2. DOC for toxoplasmosis
1. Doxycycline
2. Sulfamethoxazole + pyrimethamine
103
DOC in MRSA
DOC in syphilis
Vancomycin
Penicillin G
104
DOC in legionella
DOC in LGV
Azithromycin/ levofloxacin
Azithromycin
105
DOC in gonorrhoea
DOC in P. Carinii
Ceftriaxone
Co-trimoxazole
106
DOC in Actinomycosis
DOC in plague
1. Penicillin G
2 streptomycin
107
DOC in kala azar
Sodium stibogluconate
108
Chemoprophylactic agent for cholera
Chemoprophylactic agent for rheumatic fever
Tetracycline
Benzathine penicillin
109
Prophylaxis for streptococci
Prophylaxis for neisseria meningitis
Penicillin
Rifampicin/ ciplox
110
Prophylaxis for clostridium perfringens
Prophylaxis for clostridium tetani
Metronidazole
Penicillin
111
Prophylaxis for yersinia pestis- plague is ….
Prophylaxis for bordetella pertusis is …
Tetracycline/ cotrimoxazole
Erythromycin
112
Mycobacterium TB prophylaxis
Prophylaxis for leptospirosis
INH+ rifampicin
Doxycycline
113
Drug used for chloroquine resistant malaria
Drug for chloroquine resistant p falciparum and p vivax
Mefloquine
Halofantrine
114
S/E of chloroquine (5)
1. Retinal toxicity
2. Corneal deposits
3. Blurred vision
4. Pigmentary bulls eye retinopathy
5. Myopathy
115
Primaquine is effective for
Primaquine is ineffective against …
Radical cure of P.vivax
P.falciparum
116
S/E of primaquine
Lumefantrine and pyronaridine are …..
Hemolysis in G6PD
Anti malarial
117
DOC for cerebral malaria
Artesunate 1st
Quinine 2nd
118
S/E of quinine
Special feature of quinine
Hypoglycemia
Safe in pregnancy
119
MOA of ketoconazole (2)
Impairs ergosterol synthesis
Inhibit lanosterol 14 demethylase
120
How is amphotericin B given
Parenteral amphotericin B is indicated in rx of ….(2)
Iv with glucose solution
Cryptococcal and fungal septicaemia
121
Structurally ido xuridine is …(2)
1. Thymidine analogue
2. Cannot be given orally
122
Efavirenz belongs to ….group
Eg of protease inhibitor (2)
NNRTI
Saquinavir
Nelfinavir
123
Peripheral neuropathy is commoner with (3)
1. Stavudine
2. Didanosine
3. Zalcitabine
124
S/E of zidovudine (2)
1. Myelosuppression
2. Megaloblastic anemia
125
Tuberculocidal antiTb drugs (4)
INH
Rifampicin
Pyrazinamide
Streptomycin
126
MOA of INH
S/E of INH (2)
Inhibits mycolic acid synthesis
1. Peripheral neuritis- slow acetylator
2. Hepatotoxicity -common in elderly,alcoholics
127
AntiTb with max resistant in India
Special feature of INH (2)
INH
1. Bacteriostatic against resting bacilli
2. Bacteriocidal against rapidly multiplying org- both intra and extra cellular.
128
INH associated hepatitis is more with …(3)
1. Daily alcohol consumption
2. Concomitant rifampin administration
3. Slow INH acetylator
129
Rex of INH induced peripheral neuritis
100mg pyridoxine OD with INH
130
Syndromes associated with rifampicin (4)
1. Respiratory syndrome
2. Cutaneous syndrome
3. Flu like syndrome
4. Abdominal syndrome
131
S/e of pyrazinamide (3)
1. Hepatotoxic
2. Hyperuricemia
3. Hyperglycaemia
132
Pyrazinamide is used for …..
MOA
Short course therapy of TB
MOA: ~INH -inhibits mycolic acid cell wall synthesis but intracellular action
133
Special features of pyrazinamide
Most potent drug against M leprae
Levels of CSF are high
Rifampicin
134
S/E of clofazimine (2)
1. Reddish black discolouration of skin
2. Acneform eruptions
135
DOC for leprosy , s/e
Dapsone
Hemolysis in G6PD
136
DOC for cysticercosis
Praziquantel
137
Benefits of losartan over ACEI
Beta blockers are used in …(3)
Does not cause cough/ angioedema
1. Angina
2. Migraine prophylaxis
3. HTN
138
ACEI cause cough because of ……
C/I of ACEI (3)
Bradykinin
1. B/L renal artery stenosis
2. Pregnancy
3. Pheochromocytoma
139
DOC for malignant HTN. Why is it given?
Nitroprusside as it dilates both arterioles and veins
140
Special feature of nitroprusside (3)
1. Increase guanylate cyclase
2. No central effects
3. Raised NO level with nitrates + hydralazine coadministration
141
Special feature of diazoxide
Special feature of hydralazine
Inhibits labor
Causes drug induced lupus
142
Doc for HTN crisis in pregnancy
Drugs ass with torsades de pointes (3)
Hydralazine
1. Quinidine
2. Cisapride
3. Procainamide
143
Class of antiarrythmics:
1. Lignocaine
2. Potassium channel blockers
1. Class 1B
2. Class 3.
144
DOC for
1. Ventricular arrhythmias
2. PSVT
3. WPW syndrome
1. Lidocaine
2. Adenosine
3. Procainamide
145
DOC Acute heart failure
Special feature of nisertide (2)
1. Furosemide
1. Recombinant BNP
2. Has shorter t1/2
146
Therapeutic level of digoxin
Toxicity of digoxin is ….
0.5-1.5ng/ml
More than 2.4 ng/ml
147
MOA of digoxin (2)
1. Increase Na/K + ATPase
2. Increase ventricular contractile force
148
Route of excretion of digoxin
C/I of digoxin
Kidney
HOCM
149
Digoxin toxicity consists of …(2)
1. Hypokalemia
2. Hypomagnesemia
150
Effects of nitrates on CVS physiology (2)
1. Decreases preload and afterload
2. Decrease myocardial oxygen consumption
151
S/E of nitrates (2)
1. Reflex tachycardia
2. Hypotension
152
Long acting nitrates are not used chronically because…..
Tolerance develops - due to -SH groups
153
MOA of niacin (2).
1. Raises HDL
2. Lowers TG and LDL levels
154
MOA of bile acid sequestrants (2)
1. Decrease bile acid absorption
2. Increase hepatic conversion of cholesterol to bile acids
155
MOA of gemfibrozil (2)
Fibric acid derivative
1. Increase activity of LPL
2. Decrease release of fatty acid from adipose tissue
156
MOA of Nicotinic acid (2)
1. Decrease VLDL production
2. Decrease lipolysis in Adipocytes
157
Ulcer protective drug is …..
Use of cetumixab
Sucralfate
For EGFR positive CRC ( as a single agent)
158
Use of trastuzumab
Drug used in GIST
Breast cancer
Imatinib ( TK inhibitor)
159
Structurally, heparin is a …..
S/E of heparin (2)
Polysaccharide
1. Osteoporosis
2. Hyperkalemia
160
Warfarin inhibits …..
Warfarin induced skin necrosis is due to ….
Vit K dependent factors 2,7,9,10
Protein kinase C deficiency
161
Drugs used in acute gout (3)
Drug used in chronic gout …
NSAIDS
Colchicine
Steroids
Allopurinol
162
Uricosuric drugs are (2)
Probenecid
Sulfinpyrazone
163
MOA of colchicine (2)
1. Inhibits microtubule polymerization
2. Stabilizes tubulin in microtubules
164
Special feature of colchicine
Neither analgesic nor anti I.F
165
Mc S/E of colchicine
Second generation TCA
Clomipramine is …..
Bloody diarrhoea
Maprotiline
TCA
166
S/E of amiodarone (3)
1. Pulmonary fibrosis
2. Hyperuricemia
3. Hypo/hyperthyroidism
167
Akathesia is commonly caused by …..rx…
Caused by haloperidol
Rx propanolol
168
Early feature of TCA overdose
Anticholinergic symptoms (4)
Dry mouth
Dilated pupils
Sinus tachy
Blurred vision
169
Extrapyramidal s/e are rare with …..
What are the EPS ?
Clozapine
Parkinsonism
Akathesia
Tardive dyskinesia
Acute dystonia
170
Apart from epilepsy, carbamazepine is also indicated in …(3)
1. Maniac psychosis
2. Trigeminal neuralgia
3. Atypical pain syndrome
171
S/E of carbamazepine
Increased ADH secretion—> hyponatremia
172
Prolonged sodium channel inactivation is MOA of …..(4)
1. Phenytoin
2. Carbamazepine
3. Lamotrigine
4. Valproate
173
Facilitation of GABA mediated chloride channel opening is by ……(5)
Barbiturates
BZP
Vigabatrin
Gabapentin
Valproate
174
Inhibition of T-type calcium channel (3)
1. Ethosuximide
2. Trimethadione
3. Valproate
175
Eg of dopamine agonists
Eg of COMT inhibitor
Bromocriptine
Tolcapone
176
DOC for myoclonic epilepsy
DOC for partial seizure
Valproate
Carbamazepine
177
MOA of cyclosporine
Decrease IL-2 release —> decrease in clonal proliferation of T cells
178
Cyclosporine acts on ……
S/E of cyclosporine (5)
CD4 T cells
1. Nephrotoxicity
2. HTN
3. Hyperkalemia
4. Hypertricosis
5. Tremors
179
MOA of tacrolimus
Tacrolimus belongs to ……antibiotic
Inhibit IL-2 release
Macrolides
180
Use of tacrolimus
S/e of tacrolimus (2)
Organ transplant
Nephrotoxicity
Glucose intolerance
181
Uses of Octreotide (2)
1. Variceal/ esophageal bleeding
2. AIDS patients with secretary diarrhea who failed to respond to antimicrobial or antimotility agents
182
DOC in thyroid storm
T 1/2 of propylthiouracil
Propylthiouracil
1-2 hrs
183
Indications of bromocriptine (3)
1. Indicated in galactorrhoea and infertility due to Hyperprolactinemia
2. In acromegaly
3. Idiopathic/post encephalitic parkinsonism - along with levodopa/carbidopa
184
DOC for legionnaires disease
Erythromycin
185
Main s/e of ethacrynic acid
Ototoxicity
186
Nm blockers should never be used along with …..
Aminoglycosides
187
Drug resistant cases of Kala azar (2)
Pentamidine
Amphotericin B
188
Most effective extraerythrocytic antimalarial drug
Primaquine
189
Which antimalarial drug is safe in G6PD deficiency?
Pyrimethamine
190
Which is a sulfonamide diuretic?
Post exposure prophylaxis for tb in children exposed to open cases of Tb
Acetazolamide
INH
191
Monoclonal antibody used in RCC
Most hepatotoxic anabolic steroid
Sunitinib
Stanozolol
192
MOA of bicalutamide
Which effect of morphine has the least tolerance ?
Binds to Androgen receptor
Constipation
193
Action of Dapsone is antagonized by ….
Corticosteroid which needs least systemic monitoring
PABA
Budesonide
194
Which anti asthmatic drug needs monitoring?
Corticosteroid given by inhalational route
Theophylline
Beclomethasone
195
Eg of ino dilator drugs (2)
Amrinone, Milrinone
196
Mefloquine not given with …….to prevent risk of developing ventricular arrhythmias
MOA of raloxifene
Quinidine
SERM
197
Shortest acting muscle relaxant
Post tetanic facilitation is shown by which class of muscle relaxants
Succinyl choline
Nondepolarising
198
Anesthetic agent c/I in biers block/ IVRA
Anesthetic agent which is cerebroprotective
Bupivacaine
Propofol
199
MOA of flutamide
Vasopressor of choice in hypotension due to spinal anesthesia
Anti androgen
Ephedrine
200
Only iv anesthetic agent with marked analgesic effect
Best inhalational induction agent for pediatric anesthesia
Ketamine
Sevoflurane
201
DOC for tennia solium
Halofantrine used for ….
Praziquintal
Chloroquine resistant cases of p falciparum and p vivax
202
Doc for lithium induced polyuria
Local anesthetic causing methHb
Amiloride
Prilocaine
203
Longest acting local anesthetic
Anesthetic agent with least analgesic property
Dibucaine
Halothane
204
Beta blocker with shortest t1/2
Least cardiotoxic anesthetic agent
Esmolol
Isoflurane
205
Beta 1 selective blocker used as anti glaucoma
Betaxolol
206
Shortest acting Nm blocking agent
Mivacurium
207
Anesthetic drug which increases intracranial pressure
AntiHTN which acts by producing NO
Ketamine
Sodium nitroprusside
208
Mc side effect of 5FU
Longest active beta blocker
Gastrointestinal toxicity
Nadolol
209
DOC for filariasis (2)
1. DEC
2. Ivermectin
210
Aspirin acts by inhibiting the production of …..
Antipsychotic drug having least extrapyramidal symptoms
Thromboxane A2
Clozapine
211
HUS is the s/e of which anticancer drug
NRTI with max tendency to cause peripheral neuropathy
Mitomycin
Stavudine
212
Mgt of choice for scorpion bite
Effect of d-tubocurarine can be antagonized by ….(2)
Anti venin
Neostigmine
Edrophonium
213
MOA of aminophylline
Mc side effect reported with Rx with haloperidol
PDE4 inhibitor
Akathesia
214
Opioid derivative which is partial agonist as well as antagonist
Nalorphine
Pentazozine
215
Quinidine exerts it’s action on heart by …..
Relationship of zero order kinetics to plasma drugs level
Inhibiting sodium channels
Independent
216
Long post antibiotic effect is seen with which group of drugs (2)
FQ
Aminoglycosides
217
DOC for nocardiosis
Drug used for common cold which can cause stroke
Co-trimoxazole
Phenyl-propanol-amine
218
Orally administered anti kala azar drug
Amphotericin B toxicity is monitored by
Miltefosine
Serum potassium levels
219
Anti IgE antibodies used in asthma
Drug used in prophylaxis of H influenza
Omalizumab
Rifampicin
220
Chemical used for sclerotherapy for varicose veins
Ethanolamine oleate
Phenol
221
MOA of ketotifen
Doc for diabetes insipidus
Mast cell stabilization
Intranasal desmopressin
222
Anti diabetic drug which causes lactic acidosis
Side effect of chlorpropamide
Phenformin > metformin
Cholestatic jaundice
223
Anticraving drug used for alcohol intoxication (4)
1. Topiramate
2. Acamprosate
3. Naltrexone
4. Fluoxetine
224
Retroperitoneal fibrosis is a side effect of ….
Methylsergide
225
DOC for cardiogenic shock
Intranasal calcitonin is used for ….
Dopamine
Post menopausal osteoporosis
226
Doc for malignant hyperthermia
Dantrolene sodium
227
DOC for maduramycosis
Which ATT causes longest lag period in bacterial growth?
Itraconazole
Ethambutol
228
MOA of ketanserin
Which drug is highly distributed in body fats?
5 HT 2 antagonist
Thiopentone
229
Which drug causes hand and foot syndrome?
Aprepitant is ….antagonist. Use
5FU
NK receptor antagonist
Use: prevents vomiting
230
Which drug inhibit folate synthase?
Solfonamide
231
True for inverse agonist
Drug used in relapse of P.vivax
Affinity + intrinsic activity
Primaquine
232
Antidepressant drug having least anticholinergic side effects
Fluoxetine
233
Imipramine is not displaced from protein binding sites by ….
Digoxin toxicity is not ppt by …..
Lithium
Phenytoin
234
Which drug causes osteoporosis long term?
Estrogen acts on ….
GnRH analogue
Cytoplasmic receptors
235
Antimalarial drug effective in preerythrocytic phase in liver is …..
Least glucocorticoid activity is seen with ….
Proguanil
Triamcinolone
236
Mx side effects of chronic use of phenothiazines
Food does not interfere in absorption of ….
Tardive dyskinesia
Cimetidine
237
Antiepileptic drug which acts by release of inhibiting transmitter GABA
Eg of non selective 3rd generation beta blocker
Valproic acid
Cartelol
238
SSRI used for depression and …..
Which drug is P2Y12 receptor antagonist and has reversible inhibition of ADP action?
Premature ejaculation
Ticagrelor
239
Effect of allopurinol on kidney
Use of locaserin
Causes interstitial nephritis
Anti obesity
240
Which drug should be used with caution in patients with conduction defect?
Beta blockers
241
Use of telotristat
Antiepileptic drug acting by opening of chloride channels
Diarrhoea induced by carcinoid tumor
Tiagabine
242
PD1 inhibitor anticancer drug
Pembrolizumab
243
Hyperprolactinemia is maximally caused by which atypical antipsychotic
Risperidone
244
Deficiency of which enzyme results in 5FU induced mucositis,myelosuppression,and neuropsychiatric manifestations
Dihydro-pyrimidine dehydrogenase
245
Drug used to reverse Nicotinic receptor acting competitive Nm blocking drug
Suxamethonium
246
A girl on sulphonamides, developed ab pain presenting to ER with seizures. Dx
Acute intermittent porphyria
