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Flashcards in Digestive Development 1 Deck (33):
0

What does the primitive gut extend from?

The buccopharyngeal membrane to the cloacal membrane

1

What are the 4 divisions of the gut tube?

Pharynx
Foregut
Midgut
Hindgut

2

What does endoderm form in the gut tube?

Endocrine cells of pancreas
Hepatocytes
Epithelial lining

3

What does splanchnic mesoderm form in the digestive tube?

= visceral
Stroma
Connective tissue
Peritoneal components

4

What transcription factor specifies the esophagus and stomach

SOX 2

5

What transcription factor specifies the duodenum?

PDX1

6

What transcription factor specifies the small intestine?

CDXC

7

What transcription factor specifies the large intestine and rectum?

CDXA

8

How does sonic hedgehog play a part in gut tube differentiation?

It up regulates mesoderm and mesoderm determines the type of digestive organ that forms there

9

Somatic mesoderm that lines the intraembryonic cavity ultimately becomes what?

Mesothelium
Then parietal layer

10

Once the respiratory diverticulum appears at the pharyngeal gut, what gradually happens?

They separate from each other and form the ventral respiratory portion and the dorsal esophagus portion

11

What is the upper 2/3 of the esophagus innervated by?

Vagus

12

What is the lower 1/3 of the esophagus innervated by?

Splanchnic plexus

13

The stomach rotates how when it begins developing?

90 degrees clockwise

14

What is important to note about the lumen of the duodenum during development

It closes off during 2nd month and reopens shortly after

15

Where does the duodenum receive its blood supply?

The celiac trunk
Superior mesenteric artery

16

What is the liver bud formed out of?

Endodermal epithelium

17

What is the septum transversarium

A mesodermal plate between the pericardial cavity and yolk stalk

18

How does the gallbladder and cystic duct form?

Outgrowth of the bile duct

19

What do liver cords differentiate into?

Liver parenchyma
Lining of bile duct

20

What does mesoderm of the septum transversarium give rise to?

Hematopoietic stem cells
Kupffer cells
Connective tissue

21

What transcription factor, secreted by cardiac mesoderm, is found in the hepatic region to block liver inhibitors so we can grow a liver??

FGF 2

22

What transcription factor helps the liver respond to FGF2 better?

BMPs

23

Which transcription factors help the liver differentiate into biliary cells and hepatocytes?

HNF3
HNF4

24

What are the two buds that form the pancreas?

Dorsal pancreatic bud
Ventral pancreatic bud

25

How is the main pancreatic duct formed?

The ventral pancreas moves below the dorsal one and and the duct forms from all of the ventral's and the distal portion of the dorsal pancreatic ducts

26

Where does the accessory pancreatic duct come from?

The remaining proximal portion of the dorsal pancreatic duct

27

What factors help form the dorsal pancreatic bud by repressing SHH ?

FGF2
Activin

28

What induces ventral pancreatic bud formation?

Splanchnic mesoderm

29

What is the master gene for pancreatic development?

PDX gene

30

What transcription factors dictate endocrine pancreatic cell lineage?

PAX 4
PAX6

31

If a pancreatic endocrine cell has both PAX 4 and PAX 6, what can it become?

Beta
Delta
Gamma

32

If a pancreatic cell has only PAX 6, what can it become?

Alpha