Flashcards in Digestive Development 1 Deck (33):
What does the primitive gut extend from?
The buccopharyngeal membrane to the cloacal membrane
What are the 4 divisions of the gut tube?
What does endoderm form in the gut tube?
Endocrine cells of pancreas
What does splanchnic mesoderm form in the digestive tube?
What transcription factor specifies the esophagus and stomach
What transcription factor specifies the duodenum?
What transcription factor specifies the small intestine?
What transcription factor specifies the large intestine and rectum?
How does sonic hedgehog play a part in gut tube differentiation?
It up regulates mesoderm and mesoderm determines the type of digestive organ that forms there
Somatic mesoderm that lines the intraembryonic cavity ultimately becomes what?
Then parietal layer
Once the respiratory diverticulum appears at the pharyngeal gut, what gradually happens?
They separate from each other and form the ventral respiratory portion and the dorsal esophagus portion
What is the upper 2/3 of the esophagus innervated by?
What is the lower 1/3 of the esophagus innervated by?
The stomach rotates how when it begins developing?
90 degrees clockwise
What is important to note about the lumen of the duodenum during development
It closes off during 2nd month and reopens shortly after
Where does the duodenum receive its blood supply?
The celiac trunk
Superior mesenteric artery
What is the liver bud formed out of?
What is the septum transversarium
A mesodermal plate between the pericardial cavity and yolk stalk
How does the gallbladder and cystic duct form?
Outgrowth of the bile duct
What do liver cords differentiate into?
Lining of bile duct
What does mesoderm of the septum transversarium give rise to?
Hematopoietic stem cells
What transcription factor, secreted by cardiac mesoderm, is found in the hepatic region to block liver inhibitors so we can grow a liver??
What transcription factor helps the liver respond to FGF2 better?
Which transcription factors help the liver differentiate into biliary cells and hepatocytes?
What are the two buds that form the pancreas?
Dorsal pancreatic bud
Ventral pancreatic bud
How is the main pancreatic duct formed?
The ventral pancreas moves below the dorsal one and and the duct forms from all of the ventral's and the distal portion of the dorsal pancreatic ducts
Where does the accessory pancreatic duct come from?
The remaining proximal portion of the dorsal pancreatic duct
What factors help form the dorsal pancreatic bud by repressing SHH ?
What induces ventral pancreatic bud formation?
What is the master gene for pancreatic development?
What transcription factors dictate endocrine pancreatic cell lineage?
If a pancreatic endocrine cell has both PAX 4 and PAX 6, what can it become?