Flashcards in Lymphatic System Deck (43):
What is the definitive cell type of the lymphatic system?
What is an antigen?
Any substance that can induce an immune response
What is a nonspecific immune response?
Innate; pre existing nonspecific defenses
What is a specific immune response
Cellular= cytotoxic cells
What are the t-cell markers?
T cell receptors
What do helper cd4 T cells do?
Interact with other cells to initiate an immune response
What do cytotoxic cd8 cells do?
Kill target cells
What do B cells do?
Help produce Ab
What are the B cell markers?
Where is MHC 1 found ?
All nucleated cells and platelets
It is "self"
Where is MHC 2 found?
It is on antigen presenting cells
It displays antigen
Which MHC do cytotoxic T cells interact with?
Which MHC do helper T cells interact with
How are B cells activated
Present antigen on MHC 2
Helper T cells help out
What are lymphatic nodules
Discrete collections of lymphocytes often in association with mucosal surfaces
In the alimentary canal, where are collections of nodules seen?
What epithelium covers the palantine tonsils?
Stratified squamous epithelium
What epithelium covers the pharyngeal tonsils (adenoids)
Pseudostratified Ciliated columnar ep.
What epithelium covers the lingual tonsils?
Stratified squamous epithelium
What cells are found in association with peyer's patches
What are lymph nodes?
Small bean shaped organs along the pathway of the lymphatic vessels
What do reticular cells in lymph nodes do?
Synthesis and secrete of reticular fibers and ground substance
What do dendritic cells do in lymph nodes
APC s (use MHC 1 or 2)
What function do macrophages have in lymph nodes
What do follicular dendritic cells do in lymph nodes
Bind ag-ab complexes and retain them on their cell surface for a long time
What are the two layers of the cortex of the lymph node
Where is the B cell area of the lymph node?
Where is the T cell area of a lymph node
What sinus does the afferent lymph enter into in the lymph node
What sinus in the lymph node goes from the subcapsular sinus through the cortex
Wha sinus goes from the trabecular sinus to the efferent lymph vessels
Where do lymphocytes enter lymph nodes?
High endothelial venules (hev)
What supplies the supporting framework for lymphocyte in the thymus
No reticular fibers or cells
What is the first test T cell under go in the thymus?
Must positively recognize self MHC
What are a unique feature of the thymus medulla?
What is the second test T cells undergo?
Must not positively react against self antigen (negative selection)
What are the 4 components of the blood thymus barrier ?
What's is white pulp in the spleen?
Thick accumulation of lymphocytes surrounding an artery
What are PALS
Periatrial lymphatic sheath: When a branch from the splenic artery branches off it becomes surrounded by lymphocytes and the artery becomes the central artery
What is red pulp consist of?
What are splenic cords?
Reticular mesh works that contain large numbers of cells
What are splenic sinuses?
Special sinuses with endothelial cells that allow passage in and out of the sinus