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Flashcards in Lymphatic System Deck (43):
0

What is the definitive cell type of the lymphatic system?

Lymphocytes

1

What is an antigen?

Any substance that can induce an immune response

2

What is a nonspecific immune response?

Innate; pre existing nonspecific defenses

3

What is a specific immune response

Adaptive:
Humoral= antibodies
Cellular= cytotoxic cells

4

What are the t-cell markers?

Cd2
Cd3
Cd7
T cell receptors

5

What do helper cd4 T cells do?

Interact with other cells to initiate an immune response

6

What do cytotoxic cd8 cells do?

Kill target cells

7

What do B cells do?

Help produce Ab

8

What are the B cell markers?

Cd 9
Cd 19
Cd 20
Cd 24

9

Where is MHC 1 found ?

All nucleated cells and platelets
It is "self"

10

Where is MHC 2 found?

It is on antigen presenting cells
It displays antigen

11

Which MHC do cytotoxic T cells interact with?

MHC 1

12

Which MHC do helper T cells interact with

MHC 2

13

How are B cells activated

Present antigen on MHC 2
Helper T cells help out

14

What are lymphatic nodules

Discrete collections of lymphocytes often in association with mucosal surfaces

15

In the alimentary canal, where are collections of nodules seen?

Appendix
Peyer's patches
Tonsils

16

What epithelium covers the palantine tonsils?

Stratified squamous epithelium

17

What epithelium covers the pharyngeal tonsils (adenoids)

Pseudostratified Ciliated columnar ep.

18

What epithelium covers the lingual tonsils?

Stratified squamous epithelium

19

What cells are found in association with peyer's patches

M cells

20

What are lymph nodes?

Small bean shaped organs along the pathway of the lymphatic vessels

21

What do reticular cells in lymph nodes do?

Synthesis and secrete of reticular fibers and ground substance

22

What do dendritic cells do in lymph nodes

APC s (use MHC 1 or 2)

23

What function do macrophages have in lymph nodes

APC
Phagocytize

24

What do follicular dendritic cells do in lymph nodes

Not APCs
Bind ag-ab complexes and retain them on their cell surface for a long time

25

What are the two layers of the cortex of the lymph node

Nodular cortex
Deep cortex

26

Where is the B cell area of the lymph node?

Nodular cortex

27

Where is the T cell area of a lymph node

Deep cortex

28

What sinus does the afferent lymph enter into in the lymph node

Subcapsular sinus

29

What sinus in the lymph node goes from the subcapsular sinus through the cortex

Trabecular sinuses

30

Wha sinus goes from the trabecular sinus to the efferent lymph vessels

Medullary sinus

31

Where do lymphocytes enter lymph nodes?

High endothelial venules (hev)

32

What supplies the supporting framework for lymphocyte in the thymus

Epithelioreticular cells
No reticular fibers or cells

33

What is the first test T cell under go in the thymus?

Must positively recognize self MHC

34

What are a unique feature of the thymus medulla?

Hassalls corpuscles

35

What is the second test T cells undergo?

Must not positively react against self antigen (negative selection)

36

What are the 4 components of the blood thymus barrier ?

Endothelium
Basal lamina
Macrophages
Epithelioreticular cells

37

What's is white pulp in the spleen?

Thick accumulation of lymphocytes surrounding an artery

38

What are PALS

Periatrial lymphatic sheath: When a branch from the splenic artery branches off it becomes surrounded by lymphocytes and the artery becomes the central artery

39

What is red pulp consist of?

Splenic sinuses
Splenic cords

40

What are splenic cords?

Reticular mesh works that contain large numbers of cells

41

What are splenic sinuses?

Special sinuses with endothelial cells that allow passage in and out of the sinus

42

Starting with the central artery, what is the route of blood inthe spleen

Central arteriole branches into white pulp and terminates into marginal sinus
Central arteriole continues and branches into straight arteries called peniillar arteries
Penicillar arteries empty into splenic chords which make it back to splenic sinuses