Lymphatic System

Question 0

What is an antigen?

Answer 0

Any substance that can induce an immune response

Question 1

What is the definitive cell type of the lymphatic system?

Answer 1

Lymphocytes

Question 2

What is a nonspecific immune response?

Answer 2

Innate; pre existing nonspecific defenses

Question 3

What is a specific immune response

Answer 3

Adaptive:
Humoral= antibodies
Cellular= cytotoxic cells

Question 4

What are the t-cell markers?

Answer 4

Cd2
Cd3
Cd7
T cell receptors

Question 5

What do helper cd4 T cells do?

Answer 5

Interact with other cells to initiate an immune response

Question 6

What do cytotoxic cd8 cells do?

Answer 6

Kill target cells

Question 7

What do B cells do?

Answer 7

Help produce Ab

Question 8

What are the B cell markers?

Answer 8

Cd 9
Cd 19
Cd 20
Cd 24

Question 9

Where is MHC 1 found ?

Answer 9

All nucleated cells and platelets

It is “self”

Question 10

Where is MHC 2 found?

Answer 10

It is on antigen presenting cells

It displays antigen

Question 11

Which MHC do cytotoxic T cells interact with?

Answer 11

MHC 1

Question 12

Which MHC do helper T cells interact with

Answer 12

MHC 2

Question 13

How are B cells activated

Answer 13

Present antigen on MHC 2

Helper T cells help out

Question 14

What are lymphatic nodules

Answer 14

Discrete collections of lymphocytes often in association with mucosal surfaces

Question 15

In the alimentary canal, where are collections of nodules seen?

Answer 15

Appendix
Peyer’s patches
Tonsils

Question 16

What epithelium covers the palantine tonsils?

Answer 16

Stratified squamous epithelium

Question 17

What epithelium covers the pharyngeal tonsils (adenoids)

Answer 17

Pseudostratified Ciliated columnar ep.

Question 18

What epithelium covers the lingual tonsils?

Answer 18

Stratified squamous epithelium

Question 19

What cells are found in association with peyer’s patches

Answer 19

M cells

Question 20

What are lymph nodes?

Answer 20

Small bean shaped organs along the pathway of the lymphatic vessels

Question 21

What do reticular cells in lymph nodes do?

Answer 21

Synthesis and secrete of reticular fibers and ground substance

Question 22

What do dendritic cells do in lymph nodes

Answer 22

APC s (use MHC 1 or 2)

Question 23

What function do macrophages have in lymph nodes

Answer 23

APC

Phagocytize

Question 24

What do follicular dendritic cells do in lymph nodes

Answer 24

Not APCs | Bind ag-ab complexes and retain them on their cell surface for a long time

Question 25

What are the two layers of the cortex of the lymph node

Answer 25

Nodular cortex | Deep cortex

Question 26

Where is the B cell area of the lymph node?

Answer 26

Nodular cortex

Question 27

Where is the T cell area of a lymph node

Answer 27

Deep cortex

Question 28

What sinus does the afferent lymph enter into in the lymph node

Answer 28

Subcapsular sinus

Question 29

What sinus in the lymph node goes from the subcapsular sinus through the cortex

Answer 29

Trabecular sinuses

Question 30

Wha sinus goes from the trabecular sinus to the efferent lymph vessels

Answer 30

Medullary sinus

Question 31

Where do lymphocytes enter lymph nodes?

Answer 31

High endothelial venules (hev)

Question 32

What supplies the supporting framework for lymphocyte in the thymus

Answer 32

Epithelioreticular cells | No reticular fibers or cells

Question 33

What is the first test T cell under go in the thymus?

Answer 33

Must positively recognize self MHC

Question 34

What are a unique feature of the thymus medulla?

Answer 34

Hassalls corpuscles

Question 35

What is the second test T cells undergo?

Answer 35

Must not positively react against self antigen (negative selection)

Question 36

What are the 4 components of the blood thymus barrier ?

Answer 36

Endothelium Basal lamina Macrophages Epithelioreticular cells

Question 37

What's is white pulp in the spleen?

Answer 37

Thick accumulation of lymphocytes surrounding an artery

Question 38

What are PALS

Answer 38

Periatrial lymphatic sheath: When a branch from the splenic artery branches off it becomes surrounded by lymphocytes and the artery becomes the central artery

Question 39

What is red pulp consist of?

Answer 39

Splenic sinuses | Splenic cords

Question 40

What are splenic cords?

Answer 40

Reticular mesh works that contain large numbers of cells

Question 41

What are splenic sinuses?

Answer 41

Special sinuses with endothelial cells that allow passage in and out of the sinus

Question 42

Starting with the central artery, what is the route of blood inthe spleen

Answer 42

Central arteriole branches into white pulp and terminates into marginal sinus Central arteriole continues and branches into straight arteries called peniillar arteries Penicillar arteries empty into splenic chords which make it back to splenic sinuses