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Cell Bio Block 3 > Lymphatic System > Flashcards

Lymphatic System Flashcards

0
Q

What is an antigen?

A

Any substance that can induce an immune response

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1
Q

What is the definitive cell type of the lymphatic system?

A

Lymphocytes

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2
Q

What is a nonspecific immune response?

A

Innate; pre existing nonspecific defenses

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3
Q

What is a specific immune response

A

Adaptive:
Humoral= antibodies
Cellular= cytotoxic cells

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4
Q

What are the t-cell markers?

A

Cd2
Cd3
Cd7
T cell receptors

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5
Q

What do helper cd4 T cells do?

A

Interact with other cells to initiate an immune response

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6
Q

What do cytotoxic cd8 cells do?

A

Kill target cells

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7
Q

What do B cells do?

A

Help produce Ab

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8
Q

What are the B cell markers?

A

Cd 9
Cd 19
Cd 20
Cd 24

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9
Q

Where is MHC 1 found ?

A

All nucleated cells and platelets

It is “self”

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10
Q

Where is MHC 2 found?

A

It is on antigen presenting cells

It displays antigen

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11
Q

Which MHC do cytotoxic T cells interact with?

A

MHC 1

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12
Q

Which MHC do helper T cells interact with

A

MHC 2

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13
Q

How are B cells activated

A

Present antigen on MHC 2

Helper T cells help out

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14
Q

What are lymphatic nodules

A

Discrete collections of lymphocytes often in association with mucosal surfaces

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15
Q

In the alimentary canal, where are collections of nodules seen?

A

Appendix
Peyer’s patches
Tonsils

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16
Q

What epithelium covers the palantine tonsils?

A

Stratified squamous epithelium

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17
Q

What epithelium covers the pharyngeal tonsils (adenoids)

A

Pseudostratified Ciliated columnar ep.

18
Q

What epithelium covers the lingual tonsils?

A

Stratified squamous epithelium

19
Q

What cells are found in association with peyer’s patches

A

M cells

20
Q

What are lymph nodes?

A

Small bean shaped organs along the pathway of the lymphatic vessels

21
Q

What do reticular cells in lymph nodes do?

A

Synthesis and secrete of reticular fibers and ground substance

22
Q

What do dendritic cells do in lymph nodes

A

APC s (use MHC 1 or 2)

23
Q

What function do macrophages have in lymph nodes

A

APC

Phagocytize

24
Q

What do follicular dendritic cells do in lymph nodes

A

Not APCs

Bind ag-ab complexes and retain them on their cell surface for a long time

25
Q

What are the two layers of the cortex of the lymph node

A

Nodular cortex

Deep cortex

26
Q

Where is the B cell area of the lymph node?

A

Nodular cortex

27
Q

Where is the T cell area of a lymph node

A

Deep cortex

28
Q

What sinus does the afferent lymph enter into in the lymph node

A

Subcapsular sinus

29
Q

What sinus in the lymph node goes from the subcapsular sinus through the cortex

A

Trabecular sinuses

30
Q

Wha sinus goes from the trabecular sinus to the efferent lymph vessels

A

Medullary sinus

31
Q

Where do lymphocytes enter lymph nodes?

A

High endothelial venules (hev)

32
Q

What supplies the supporting framework for lymphocyte in the thymus

A

Epithelioreticular cells

No reticular fibers or cells

33
Q

What is the first test T cell under go in the thymus?

A

Must positively recognize self MHC

34
Q

What are a unique feature of the thymus medulla?

A

Hassalls corpuscles

35
Q

What is the second test T cells undergo?

A

Must not positively react against self antigen (negative selection)

36
Q

What are the 4 components of the blood thymus barrier ?

A

Endothelium
Basal lamina
Macrophages
Epithelioreticular cells

37
Q

What’s is white pulp in the spleen?

A

Thick accumulation of lymphocytes surrounding an artery

38
Q

What are PALS

A

Periatrial lymphatic sheath: When a branch from the splenic artery branches off it becomes surrounded by lymphocytes and the artery becomes the central artery

39
Q

What is red pulp consist of?

A

Splenic sinuses

Splenic cords

40
Q

What are splenic cords?

A

Reticular mesh works that contain large numbers of cells

41
Q

What are splenic sinuses?

A

Special sinuses with endothelial cells that allow passage in and out of the sinus

42
Q

Starting with the central artery, what is the route of blood inthe spleen

A

Central arteriole branches into white pulp and terminates into marginal sinus
Central arteriole continues and branches into straight arteries called peniillar arteries
Penicillar arteries empty into splenic chords which make it back to splenic sinuses

Cell Bio Block 3 (9 decks)

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