Disorders of Thyroid Gland Flashcards
(41 cards)
It is the largest endocrine gland
THYROID GLAND
Hormone secreted by anterior pituitary gland which influences TSH
THYROTROPIN
refers to thyroid hormone production that is normal
EUTHYROID
- Primary screening test for thyroid function
- Used for monitoring thyroid hormone replacement therapy
- Differentiates between thyroid gland disorders and pituitary/hypothalamic disorders
SERUM THYROID-STIMULATING HORMONE (TSH)
- It measures free (unbound) thyroxine (active fraction)
- useful in monitoring treatment for hyperthyroidism
SERUM FREE T4
Give normal range of T4 and T3
T4: 5.4 to 11.5 Ug/dL (57 to 148 mol/L)
T3: 260 to 480 pg/dL (4.0 to
7.4 pmol/L)
Measures total T3 and T4 (protein bound and free hormone levels)
SERUM T3 & T4
T/F:
T4 is a more accurate indicator of hyperthyroidism severity than T3
TRUE
Normal range of T4 (Thyroxine)
0.7 -2.0 mg/dl or 10-20 pmol/L
Normal uptake value of T3 Resin Uptake Test
Normal uptake value: 25% to 35%
> 35% (Increased uptake) = HYPERthyroidism
<25% (Decreased uptake) = HYPOthyroidism
- Indirect measure of unsaturated thyroxine-binding globulin (TBG)
- Assesses available binding sites for thyroid hormone
T3 Resin Uptake Test
These test identifies autoimmune thyroid diseases
THYROID ANTIBODY TESTS
Clinical significance of RAIUT
- Hyperthyroidism = increased iodine uptake
- Hypothyroidism = decreased iodine uptake
Examples of autoimmune thyroid diseases:
- Hashimoto Thyroiditis
- Grave’s disease
- Chronic autoimmune thyroid disease
- SLE
- Primary test for evaluating thyroid masses
- Categorizes results as benign, malignant, suspicious, or nondiagnostic
FINE NEEDLE ASPIRATION (FNA) BIOPSY
Measures rate of iodine uptake by the thyroid gland
RADIOACTIVE IODINE UPTAKE TEST (RAIUT)
What iodine is used in RAIUT?
Iodine-123
Hypothyroidism present at birth, often linked to maternal thyroid deficiency
NEONATAL HYPOTHYROIDISM
Specific disorders of the thyroid gland
[SHHT (shit)]
- SIMPLE GOITER
- HYPOTHYROIDISM
-Myxedema (adults)
-Cretinism (pedia) - HYPERTHYROIDISM (GRAVE’S DISEASE)
- THYROID STORM
Hot nodules
Hyperfunctioning
Cold nodules
Hypofunctioning; higher chances of malignancy
- Used to detect persistence or recurrence of thyroid carcinoma
- Measured by radioimmunoassay
Serum Thyroglobulin (Tg) Measurement
Meds that may alter thyroid results
- Amiodarone
- Aspirin
- Cimetidine (Tagamet)
- Phenytoin (Dilantin)
- Propranolol (Inderal)
- Enlargement of the thyroid gland and not caused by inflammation or neoplasm
- Due to decreased iodine intake
SIMPLE GOITER