diuretics

Question 1

carbonic anhydrase inhibitors example and mech of action - where
what probs
when don’t use

Answer 1

acetazolamide
bicarb and H+ are not reabsorbed

met acidosis
don’t use in CKD

Question 2

loop diuretics example and mech of action - where
what probs

Answer 2

frusemide
bumetanide

Loop of henle

Na/K/2Cl blocker

kidney stones
hypocalcemia
calciuria
hypokalemia
acute renal failure
deafness

Question 3

thiazide (like) diuretics example and mech of action - where
what probs

Answer 3

chlorthalizone
indapamide

DCT
Na/Cl

HYPERcalcemia
hypokalemia
hyponatremia (partic old ppl)

Question 4

K sparing diuretics example and mech of action - where
what probs

Answer 4

aldosterone antagonists
- spironolactone
- amiloride

collecting tubules
amiloride - Na channels blocked
spironolactone - aldosterone blocked so fewer Na channels

Hyperkalemia
gynecomastia

Question 5

clinical osmotic diuretic

Answer 5

mannitol
drags all solutes into the lumen
polyuria/polydipsia

Question 6

altitude sickness kidney med

Answer 6

acetazolamide (carbonic anhydrase inhibitor)

Question 7

thiazide diuretics when use don’t use

Answer 7

hypertension

Question 8

loop when use

Answer 8

HF hypertension
very volume overloaded like CKD

Question 9

aldosterone inh when use

Answer 9

HF

Question 10

hyper K+ prob

Answer 10

vent arrhythmias

Question 11

amiloride when use don’t use

Answer 11

with frusemide so cancel out K effects

Question 12

DKA/HHS

Question 13

when stop diuretic

Answer 13

hypotensive
dehydrated
hypo/hyperK
post surgery poor urine output