Drug Reactions Flashcards Preview

Step 1 Pharmacology > Drug Reactions > Flashcards

Flashcards in Drug Reactions Deck (49):
1

Cardiovascular - What are the causal agents of Coronary vasospasm?

Cocaine, sumatriptan, ergot alkaloids

2

Cardiovascular - What are the causal agents of Cutaneous flushing?

Vancomycin, Adenosine, Niacin, Ca2+ channel blockers
(Acronym - VANC)

3

Cardiovascular - What are the causal agents of Dilated cardiomyopathy?

Doxorubicin, daunorubicin

4

Cardiovascular - What are the causal agents of Torsades de pointes?

Class III (e.g., sotalol) and class IA (e.g., quinidine) antiarrhythmics, macrolide antibiotics, antipsychotics, TCAs

5

Endocrine/reproductive - What are the causal agents of Adrenocortical insufficiency?

HPA suppression 2° to glucocorticoid withdrawal

6

Endocrine/reproductive - What are the causal agents of Hot flashes?

Tamoxifen, clomiphene

7

Endocrine/reproductive - What are the causal agents of Hyperglycemia?

Tacrolimus, Protease inhibitors, Niacin, HCTZ, β-blockers, Corticosteroids
(Acronym - Taking Pills Necessitates Having Blood Checked)

8

Endocrine/reproductive - What are the causal agents of Hypothyroidism?

Lithium, amiodarone, sulfonamides

9

GI - What are the causal agents of Acute cholestatic hepatitis, jaundice?

Erythromycin

10

GI - What are the causal agents of Diarrhea?

Metformin, Erythromycin, Colchicine, Orlistat, Acarbose
(Acronym - Might Excite Colon On Accident)

11

GI - What are the causal agents of Focal to massive hepatic necrosis?

Halothane, Amanita phalloides (death cap mushroom), Valproic acid, Acetaminophen

12

GI - What are the causal agents of Hepatitis?

INH

13

GI - What are the causal agents of Pancreatitis?

Didanosine, Corticosteroids, Alcohol, Valproic acid, Azathioprine, Diuretics (furosemide, HCTZ
(Acronym - Drugs Causing A Violent Abdominal Distress)

14

GI - What are the causal agents of Pseudomembranous colitis?

Clindamycin, ampicillin, cephalosporins
Antibiotics predispose to superinfection by resistant C. difficile

15

Hematologic - What are the causal agents of Agranulocytosis?

Dapsone, Clozapine, Carbamazepine, Colchicine, Methimazole, Propylthiouracil
(Acronym - Drugs CCCrush Myeloblasts and Promyelocytes)

16

Hematologic - What are the causal agents of Aplastic anemia?

Carbamazepine, Methimazole, NSAIDs, Benzene, Chloramphenicol, Propylthiouracil
(Acronym - Can't Make New Blood Cells Properly)

17

Hematologic - What are the causal agents of Direct Coombs - positive hemolytic anemia?

Methyldopa, penicillin

18

Hematologic - What are the causal agents of Gray baby syndrome?

Chloramphenicol

19

Hematologic - What are the causal agents of Hemolysis in G6PD deficiency?

INH, Sulfonamides, Dapsone, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin
(Acronym - hemolysis IS D PAIN)

20

Hematologic - What are the causal agents of Megaloblastic anemia?

Phenytoin, Methotrexate, Sulfa drugs
(Acronym - Having a blast with PMS)

21

Hematologic - What are the causal agents of Thrombocytopenia?

Heparin, cimetidine

22

Hematologic - What are the causal agents of Thrombotic complications?

OCPs (e.g., estrogens)

23

Musculoskeletal/skin/connective tissue - What are the causal agents of Fat redistribution?

Protease inhibitors, Glucocorticoids
(Acronym - Fat PiG)

24

Musculoskeletal/skin/connective tissue - What are the causal agents of Gingival hyperplasia?

Phenytoin, verapamil, cyclosporine, nifedipine

25

Musculoskeletal/skin/connective tissue - What are the causal agents of Hyperuricemia (gout)?

Pyrazinamide, Thiazides, Furosemide, Niacin, Cyclosporine
(Acronym - Painful Tophi and Feet Need Care)

26

Musculoskeletal/skin/connective tissue - What are the causal agents of Myopathy?

Fibrates, niacin, colchicine, hydroxychloroquine, interferon-α, penicillamine, statins, glucocorticoids

27

Musculoskeletal/skin/connective tissue - What are the causal agents of Osteoporosis?

Corticosteroids, heparin

28

Musculoskeletal/skin/connective tissue - What are the causal agents of Photosensitivity?

Sulfonamides, Amiodarone, Tetracyclines, 5-FU
(Acronym - SAT For Photo)

29

Musculoskeletal/skin/connective tissue - What are the causal agents of Rash (Stevens-Johnson syndrome)?

Anti-epileptic drugs (ethosuximide, carbamazepine, lamotrigine, phenytoin, phenobarbital), Allopurinal, Sulfa drugs, Penicillin
(Remember: Steven Johnson has epileptic Allergy to Sulfa drugs and Penicillin)

30

Musculoskeletal/skin/connective tissue - What are the causal agents of SLE-like syndrome?

Sulfa drugs, Hydralazine, INH, Procainamide, Phenytoin, Etanercept)
(Remember: Having lupus is SHIPP-E)

31

Musculoskeletal/skin/connective tissue - What are the causal agents of Teeth discoloration?

Tetracyclines

32

Musculoskeletal/skin/connective tissue - What are the causal agents of Tendonitis, tendon rupture, and cartilage damage?

Fluroquinolones

33

Neurologic - What are the causal agents of Cinchonism?

Quinidine, quinine

34

Neurologic - What are the causal agents of Parkinson-like syndrome?

Antipsychotics, Reserpine, Metoclopramide
(Acronym: cogwheel rigidity of ARM)

35

Neurologic - What are the causal agents of Seizures?

INH (vitamin B6 deficiency), Bupropionm Imipenem/cilastatin, Tramadol, Enflurane, Metoclopramide
(Remember: With seizures, I BITE My tongue)

36

Neurologic - What are the causal agents of Tardive dyskinesia?

Antipsychotics, metoclopramide

37

Renal/Genitourinary - What are the causal agents of Diabetes insipidus?

Lithium, demeclocycline

38

Renal/Genitourinary - What are the causal agents of Fanconi syndrome?

Expired tetracycline

39

Renal/Genitourinary - What are the causal agents of Hemorrhagic cystitis?

Cyclophosphamide, ifosfamide
(Prevent by coadministering with mesna)

40

Renal/Genitourinary - What are the causal agents of Interstitial nephritis?

Methicillin, NSAIDs, furosemide

41

Renal/Genitourinary - What are the causal agents of SIADH?

Carbamazepine, Cyclophosphamide, SSRIs
(Acronym - Can't Concentrate Serum Sodium)

42

Respiratory - What are the causal agents of Dry cough?

ACE inhibitors

43

Respiratory - What are the causal agents of Pulmonary fibrosis?

Bleomycin, Amiodarone, Busulfan, Methotrexate
(Acronym - Breathing Air Badly from Medications)

44

Multiorgan - What are the causal agents of Antimuscarinic?

Atropine, TCAs, H1-blockers, antipsychotics

45

Multiorgan - What are the causal agents of Disulfiram-like reaction?

Metronidazole, certain cephalosporins, griseofulvin, procarbazine, 1st-generation sulfonylureas

46

Multiorgan - What are the causal agents of Nephrotoxicity/ototoxicity?

Aminoglycosides, vancomycin, loop diuretics, cisplatin

47

What drugs are Cytochrome P-450 Inducers (+)?

Chronic alcohol use, Modafinil, St. John's wort, Phenytoin, Phenobarbital, Nevirapine, Rifampin, Griscofulvin, and Carbamazepine
(Acronym - Chronic alcoholic Mona Steals Phen-Phen and Never Refuses Greasy Carbs)

48

What drugs are Cytochrome P-450 Substrates?

Anti-epileptics, Antidepressants, Antipsychotics, Anesthetics, Theophylline, Warfarin, Statins, OCPs
(Acronym - Always, Always, Always, Always Think When Starting Others)

49

What drugs are Cytochrome P-450 Inhibitors (-)?

Acute alcohol abuse, Gemfibrozil, Ciprofloxacin, Isoniazid, Grapefruit juice, Quinidine, Amiodarone, Ketoconazole, Macrolides, Sulfonamides, Cimetidine, Ritonavir)
(Acronym - A cute Gentleman "Cipped" Iced Grapefruit juice Quickly And Kept Munching on Soft Cinammon Rolls)