β-blockers Flashcards Preview

Step 1 Pharmacology > β-blockers > Flashcards

Flashcards in β-blockers Deck (13):
1

What are the effects of β-blockers on Angina pectoris?

↓ heart rate and contractility, resulting in ↓ O2 consumption

2

What are the effects of β-blockers on MI?

↓ mortality (metoprolol, carvedilol, and bisoprolol)

3

What are the effects of β-blockers on SVT (metoprolol, esmolol)?

↓ AV conduction velocity (class II antiarrhythmic)

4

What are the effects of β-blockers on Hypertension?

↓ cardiac output, ↓ renin secretion (due to β1-receptor blockade on JGA cells)

5

What are the effects of β-blockers on CHF?

Slow progression of chronic failure

6

What are the effects of β-blockers on Glaucoma (timolol)?

↓ secretion of aqueous humor

7

What are the toxicities of β-blockers?

Impotence, CV adverse effects (bradycardia, AV block, CHF), CNS adverse effects (seizures, sedation, sleep alterations), dyslipidemia (metoprolol), and asthmatics/COPDers (may cause exacerbation)

8

Why should β-blockers be avoided in cocaine users?

Risk of unopposed α-adrenergic receptor agonist activity

9

Why are β-blockers not contraindicated in diabetics?

Despite theoretical concern of masking hypoglycemia in diabetics, benefits likely outweigh risks

10

Which β-blockers are β1-selective antagonists (β1 > β2)?

Acebutolol (partial agonist), Atenolol, Betaxolol, Esmolol, metoprolol (Selective antagonists mostly go from A to M (β1 with 1st half of alphabet))

11

Which β-blockers are nonselective antagonists (β1 = β2)?

Nadolol, Pindolol (partial agonist), Propranolol, Timolol (Nonselective antagonists mostly go from N to Z (β2 with 2nd half of alphabet))

12

Which β-blockers are nonselective α- and β-antagonists?

Carvedilol and labetalol (not "-olol")

13

What does Nebivolol do?

Combines cardiac-selective β1-adrenergic blockade with stimulation of β3 receptors, which activate NO synthase in the vasculature