Sympathomimetics Flashcards Preview

Step 1 Pharmacology > Sympathomimetics > Flashcards

Flashcards in Sympathomimetics Deck (20):
1

What receptors does Epinephrine affect?

β > α
α effects predominate at high doses

2

What receptors does Norepinephrine affect?

α1 > α2 > β1

3

What receptors does Isoproterenol affect?

β1 = β2

4

What receptors does Dopamine affect?

D2 = D2 > β > α

5

What receptors does Dobutamine affect?

β1 > β2,α

6

What receptors does Phenylephrine affect?

α1 > α2

7

What receptors does Albuterol, Salmeterol, and Terbutaline affect?

β2 > β1

8

What are the applications of Epinephrine?

Anaphylaxis, open angle glaucoma, asthma, hypotension

9

What are the applications of Norepinephrine?

Hypotension (but ↓ renal perfusion)

10

What are the applications of Isoproterenol?

Electrophysiologic evaluation of tachyarrhythmias ; can worsen ischemia

11

What are the applications of Dopamine?

Unstable bradycardia, heart failure, shock; inotropic and chronotropic α effects predominate at high doses

12

What are the applications of Dobutamine?

Heart failure (inotropic > chronotropic), cardiac stress testing

13

What are the applications of Phenylephrine?

Hypotension (vasoconstrictor), ocular procedures (mydriatic), rhinitis (decongestant)

14

What are the applications of Albuterol, Salmeterol, and Terbutaline?

Albuterol for acute asthma; salmeterol for long-term asthma or COPD control; terbutaline to reduce premature uterine contractions

15

Indirect sympathomimetics - What are the effects of Amphetamines?

Indirect general agonist, reuptake inhibitor, also releases stored catecholamines

16

Indirect sympathomimetics - What are the effects of Ephedrine?

Indirect general agonist, releases stored catecholamines

17

Indirect sympathomimetics - What are the effects of Cocaine?

Indirect general agonist, reuptake inhibitor

18

Indirect sympathomimetics - What are the applications of Amphetamines?

Narcolepsy, obesity , ADD

19

Indirect sympathomimetics - What are the applications of Ephedrine?

Nasal decongestion, urinary incontinence, hypotension

20

Indirect sympathomimetics - What are the applications of Cocaine?

Causes vasoconstriction and local anesthesia; never give β-blockers if cocaine intoxication is suspected (can lead to unopposed α1 activation and extreme hypertension)