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Flashcards in Drugs Deck (57)
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1

Maropitant (Cerenia)

> Very effective anti-emetic
- Use in acute gastroenteritis, cytotoxic induced vomiting, motion sickness [higher dose]
- effective against central and peripheral causes of emesis as works on last step of vomiting reflex in CNS
- NK1 Receptor antagonist in Nucleus Tractus Solitarius

2

Metoclopramide

- Antiemetic
- D2 and 5HT3 antagonist [CRTZ and periphery], and peripheral procholinergic effects
- use in central/peripherally induced vomiting, chemotherapy, gastroesophageal reflux, decreased gastric emptying cases
- more potent in dogs dueto D2 activity

3

Phenothiazines

- Amtiemetic
- a1 and a2 Ant, D2 Ant, H1 and H2 Ant, Muscarinic Cholinergic Ant
- acts on CRTZ, vomiting centre, vestibular system and periphery
> not vet registered so few indications

4

Diphenhydrinate (Dramamine)

Anthistamines: Antiemetic
- act on CRTZ in motion sickness in the DOG only
- off label use in UK

5

Diphenhydramine (Benadryl)

Anthistamines:
- H1 and H2 in CRTZ
- Antiallergy

6

Dolasetron (Anzemet)

- 5HT3 antagonist (CRTZ and periphery)
- usually for cytotoxic drug induced emesis
- much more effective antiemetic than metoclopramide
- expensive

7

Ondansetron (Zofran)`

- 5HT3 antagonist (CRTZ and periphery)
- usually for cytotoxic drug induced emesis
- much more effective antiemetic than metoclopramide
- expensive

8

Atropine

Anticholinergic
-Motion sickness (M1 Ant in vestibular apparatus) BUT M2 effects cause severe side effects - delayed gastric emptying, ileus)

9

Butylscopolamine (Hyoscine)

Anticholinergic
-Motion sickness (M1 Ant in vestibular apparatus) BUT M2 effects cause severe side effects - delayed gastric emptying, ileus)

10

Propantheline

Anticholinergic
-Motion sickness (M1 Ant in vestibular apparatus) BUT M2 effects cause severe side effects - delayed gastric emptying, ileus)

11

Isopropamide

Anticholinergic
-Motion sickness (M1 Ant in vestibular apparatus) BUT M2 effects cause severe side effects - delayed gastric emptying, ileus)

12

Nonsystemic antacids

Anti-ulcer
- inexpensive
- oral administration different in V+ patient
- frequent administration ~4hrs = low owner compliance
- treat but DO NOT PREVENT

13

Cimetidine (Zitac)

- H2 R antagonists
- Anti-ulcer
- effective for gastric ulceration caused by NSAIDs and uraemia (amongst others)
- vet registered
- differ to other H2 R ants in potency, but = effective

14

Sucralfate

Anti-ulcer

15

Misoprostol (Cytotec)

Anti-ulcer
- Synthetic PGE2
- Management/prevention of NSAID tox
- Causes abortion in humans (morning after pill)

16

Omeprazole (Losec)

Anti-ulcer

17

Ranitidine (Zantac)

- H2 R antagonists
- Anti-ulcer
- effective for gastric ulceration caused by NSAIDs and uraemia (amongst others)
- differ to other H2 R ants in potency, but = effective
- prokinetic

18

Famotidine (Pepcid)

- H2 R antagonists
- Anti-ulcer
- effective for gastric ulceration caused by NSAIDs and uraemia (amongst others)
- differ to other H2 R ants in potency, but = effective

19

Apomorphine

- NOT morphine!
-D2 Ag
- Potent emetic in the dog

20

Xylazine

- A2 Ag
- Sedative
- Potent emetic in cats

21

Prochlorperazine

- A2 blocker
- Potent antiemetic in cats

22

Kaolin

- Absorbant/prtectant for diarrhoea?

23

Bismuth salicylate

- Absorbant/protectant for diarrhoea
- Avoid in cats

24

FLunixin meglumine

NSAID analgesic and antipyrexic

25

Moxidectin

Wormer
- effective against cyathostomin larvae but causes D+ in its own right
± corticosteroids?

26

Fenbendazole

WOrmer
- 10mg/kg PO SID 5 days
- effective against cyathostomin larvae but causes D+ in its own right
± corticosteroids

27

Lactulose

Laxative

28

Cyclosporine

Immunosupressant

29

Ketoconazole

Prolongs action of cyclosporine

30

Methodone

Opioid