Drugs for Inflammation Flashcards Preview

Jonathan's Locomotor > Drugs for Inflammation > Flashcards

Flashcards in Drugs for Inflammation Deck (22):
1

What is the general action of glucocorticoids?

inhibit AA release and metabolism

2

What is the action of NSAIDs?

COX inhibition

3

What is the effect of antagonising CysLT1 receptors?

block LTC4 and LTD4 actions. Prevent bronchospasm and nasal congestion

4

T/F The action of the inducible Cox-2 is not as strong as the constitutive Cox-1

False, Cox-2 can be 100x more potent

5

What is one reason why tumor cells often cause acute and chronic inflammation

tumors induce Cox-2

6

Which prostaglandin is most related to inflammation

PGE2

7

What prevents us from using prostaglandin as drugs?

too unstable and expensive

8

T/F Aspirin is indicated for patients with gout

False, although anti-inflammatory, aspirin can compete with the clearance of urea at the kidneys

9

Why is NSAID useful for gout?

It blocks the action of PGE2, hence reducing inflammation

10

How does NSAID cause analgesia?

by removing sensitisation from AA products

11

Why is paracetamol preferred as an antipyretic?

aspirin tends to cause gastric bleeding more so than paracetamol

12

How does NSAID cause gastric ulcer?

by inhibiting PGE2, it also inhibits the ability to repair gastric mucosa. Without the protective effect of PGE2, there may be acid reaching the gastric lumen

13

T/F NSAID is an anti-coagulative

True

14

T/F low dose aspirin can prevent CV disease

True, because it affects only platelets in the portal circulation, reducing TXA2 but not affecting vascular PGI2

15

T/F NSAIDs can sometimes cause bronchoconstriction

True, some individuals are hypersensitive, and can overproduce leukotrienes

16

How is aspirin different to other NSAIDs?

it's irreversible

17

Which drug is Reye's syndrome associated with?

aspirin

18

How is paracetamol different to NSAIDs?

it's analgesic, antipyretic, but not anti-inflammatory

19

What is the theory of COX-2 selectivity?

its hydrophobic pocket for AA is larger than that of COX-1, so it can reduce GIT side effect while retaining efficacy

20

Why has some COX-2 agents been withdrawn?

they increase CV risk in the long run, because COX-2 is the main contributor of coronary artery integrity

21

What are the three mechanisms of action of glucocorticoids?

direct transactivation
direct transrepression
tethered transrepression

22

Which protein is the target of tethered transrepression?

NF-kB, important for the induction of cytokines