Drugs With Important Actions On Blood, Inflammation, & Gout 2 Flashcards Preview

Pharmacology > Drugs With Important Actions On Blood, Inflammation, & Gout 2 > Flashcards

Flashcards in Drugs With Important Actions On Blood, Inflammation, & Gout 2 Deck (15):
0

Who makes vitB12?

ONLY THE BACTERIA.

1

Has B12 toxicity?

No significant toxicity.

2

Where are antifolate drugs useful?

In the treatment of various infections and cancers. Rapidly dividing cells are highly sensitive to folate deficiency.

3

What is the main benefit of methoxy poluethylene glycol-epoetin beta?

It is long lasting, thus it can be administered once or twice a month.

4

What do we do in patients with multiple myeloma or NHL who respond poorly to G-CSF alone?

G-CSF may be combined with the novel hematopoietic stem cell mobilizer plerixafor - an inhibitor of CXCR4.

5

Although the toxicity of G-CSF is minimal, what is the toxicity of GM-CSF?

1. Fever
2. Arthralgias
3. Capillary damage
4. Edema

6

What is pegfilgrastim?

A covalent conjugation product of filgrastim and a form of polyethylene glycol.
Much longer t1/2 that recombinant G-CSF.

7

What is lenograstim?

A glycosylated form of recombinant G-CSF - used widely in Europe.

8

What is the clinical use of romiplostim?

A subcutaneous thrombopoietin receptor agonist - used in chronic idiopathic thrombocytopenia who failed to respond to conventional treatment.

9

What is eltrombopag?

An ORAL thrombopoietin receptor agonist for chronic idiopathic thrombocytopenia that is refractory to other agents.

10

What is the only NSAID that is available in a parenteral formulation?

Ketorolac

11

Why we should not give aspirin to children with viral infections?

Because of increased risk for developing Reye's syndrome - a rare but serious syndrome of rapid liver degeneration and encephalopathy.

12

Is there a specific antidote for aspirin?

No.

13

What adverse effect have been noted with indomethacin?

Serious hematologic reactions.

14

What do we give in acetaminophen toxicity?

Acetyl-cysteine - a sulfhydryl donor (lifesaving).

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