Flashcards in Drugs With Important Actions On Blood, Inflammation, & Gout 2 Deck (15):
Who makes vitB12?
ONLY THE BACTERIA.
Has B12 toxicity?
No significant toxicity.
Where are antifolate drugs useful?
In the treatment of various infections and cancers. Rapidly dividing cells are highly sensitive to folate deficiency.
What is the main benefit of methoxy poluethylene glycol-epoetin beta?
It is long lasting, thus it can be administered once or twice a month.
What do we do in patients with multiple myeloma or NHL who respond poorly to G-CSF alone?
G-CSF may be combined with the novel hematopoietic stem cell mobilizer plerixafor - an inhibitor of CXCR4.
Although the toxicity of G-CSF is minimal, what is the toxicity of GM-CSF?
3. Capillary damage
What is pegfilgrastim?
A covalent conjugation product of filgrastim and a form of polyethylene glycol.
Much longer t1/2 that recombinant G-CSF.
What is lenograstim?
A glycosylated form of recombinant G-CSF - used widely in Europe.
What is the clinical use of romiplostim?
A subcutaneous thrombopoietin receptor agonist - used in chronic idiopathic thrombocytopenia who failed to respond to conventional treatment.
What is eltrombopag?
An ORAL thrombopoietin receptor agonist for chronic idiopathic thrombocytopenia that is refractory to other agents.
What is the only NSAID that is available in a parenteral formulation?
Why we should not give aspirin to children with viral infections?
Because of increased risk for developing Reye's syndrome - a rare but serious syndrome of rapid liver degeneration and encephalopathy.
Is there a specific antidote for aspirin?
What adverse effect have been noted with indomethacin?
Serious hematologic reactions.