dyslipidemias

Question 1

Apo B100

Answer 1

found in VLDL, IDL, LDL

Question 2

Apo B48

Answer 2

found in chylomicrons

Question 3

Apo E

Answer 3

found in CM, VLDL, IDL

Question 4

ApoC-II

Answer 4

CM, VLDL, IDL

Question 5

Apo A

Answer 5

HDL

Question 6

which apo-lipoprotein bind LDL receptor

Answer 6

B100, ApoE

Question 7

which apo-lipoprotein activates LPL?

Answer 7

Apo C-II

Question 8

which apo-lipoprotein activates LCAT

Answer 8

Apo A-I

Question 9

where are CM made?

Answer 9

enterocyets

Question 10

where are VLDL made?

Answer 10

liver

Question 11

which enzyme: reduces HMG-CoA conversion to mevalonic acid in the rate-limiting step of cholesterol biosynthesis (mainly liver and intestine).

Answer 11

HMG Coa reductase

Question 12

which enzyme:hydrolyzes TG core of Chylomicrons, VLDL, and IDL. insulin+, located in capillary walls

Answer 12

lipoprotein lipase

Question 13

which enzyme: hydrolyzes TAGs in IDL to facilitate conversion to LDL.

Answer 13

hepatic lipase

Question 14

which enzyme: present on HDL, transfers cholesteryl esters from HDL to other lipoproteins in exchange for TG, phospholipids, and cholesterol.

Answer 14

CETP (cholesterol ester transfer protein)

Question 15

which enzyme: present on HDL, transfers fatty acids from lecithin to C to form CE in HDL. Keeps C concentration low in the phospholipid monolayer.

Answer 15

LCAT(lecithin cholesterol acyl transferase)-

Question 16

what is lipoprotein(a)

Answer 16

LDL with an addt’l apolipoprotein tail attached to ApoB

Question 17

which structure has structural similarity to plasminogen, inhibits conversion to plasmin & can result in an increased inflammatory state?

Answer 17

LP (a)

Question 18

which pathway of HDL–>liver involves SR-B1 receptor on liver?

Answer 18

direct pathway

Question 19

which pathway of HFL–>liver involves the CETP?

Answer 19

indirect pathway

Question 20

WHAT TRANSPORTS CHOLESTEROL AND TG IN THE BLOOD?

Answer 20

LIPOPROTEIN FAMILES (CM, VLDL, IDL, LDL, HDL)

Question 21

WHAT ARE LIPOPROTEINS COMPOSED OF?

Answer 21

LIPID CORE SURROUNDED BY PHOSPHOLIPID MONOLAYER

Question 22

rhabdomyolysis is especially indicated with what drug?

Answer 22

gemfibrozil + statins

Question 23

what is statin triggered autoimmune myopathy?

Answer 23

AUTOANTIBODY TO HMG-COA REDUCTASE

tx with immunosuppressives

Question 24

what non-statin works by: Liver increases LDL receptors, & may increase TG

Answer 24

bile acid sequestrants

Question 25

Cholestyramine, Colestipol

Answer 25

bile acid sequestrants

Question 26

when is the use of bile acid sequestrants contraindicated?

Answer 26

high TG levels (>400)

Question 27

name that drug: RAISES HDL, MAY REDUCE Lpa

Answer 27

Nicotinic acid (Niacin)

Question 28

AE: flushing, hyperglyc, hyperuricemia, upper GI distress, liver toxicity

Answer 28

Nicotinic acid (Niacin)

Question 29

name that drug: PRIMARILY FOR HYPERTRIGLYCERIDEMIA, LOWER TG’S 20 TO 50%

Answer 29

fibric acids

Question 30

which drug is assc'd with gallstones?

Answer 30

fibric acid

Question 31

name that drug: IMPAIRS DIETARY AND BILIARY CHOLESTEROL ABSORPTION,

Answer 31

ezetimibe

Question 32

DM can result in very high _____

Answer 32

TG

Question 33

if person presents with very high LDL, need to r/o what?

Answer 33

hypothyroidism

Question 34

name that drug: Regulates expression of LDL RECEPTORS, Chaperone molecule, MONOCLONAL AB, prevent LDL receptors from break down

Answer 34

PCSK9 inhibitors