Flashcards in coronary atherosclerosis & MI Deck (19)
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1
wat is the response to injury model for ASCVD?
1. endothelial injury
2. monocytes attach to endothelial cell
3. growth factors released
4. platelets may participate
5. complex lesions evolve over years
2
what is the Intimal collection of MACROPHAGES AND LIPID LADEN SMC’s?
fatty streak
3
what is the advanced lesion?
fibrous plaque
4
what is the MOST COMMON CAUSE OF DEATH IN DIABETIC PATIENTS
atherosclerosis
5
what is unstable angina
new onset, subjectively worse discomfort, onset with less activity, angina at rest
6
typically lasts LESS THAN 30 MINS, onset gradual, worsened by work & lying down
angina
7
stress testing is used to dx
atypical chest discomfort
8
when is stress testing not indicated?
asympt men or women
9
ST depression >2 on stress test is a certain dx of?
Myocardial ischemia
10
do beta blockers have any effect on O2 supply?
no, just reduce myocardial oxygen demand
11
what is a stable angina pectoris?
same pattern each time
12
stress testing can be used for prognosis of?
stable angina, post-MI, post-revascularization
13
what drugs can be used for pharmacological stress testing?
adenosine, dipyramidole, dobutamine
14
what tx for MI decrease pre-load, coronary dilation, enhance endothelial activity
nitrates
15
what tx for MI decrease HR and contractility
beta blockers
16
what tx for MI prevent spasms, reduction of afterload, some reduce contractility, DECREASE AFTERLOAD
CCB
17
factors affecting supply of myocardium
1. vascular resistance
2. coronary blood flow
3. O2 carrying capacity
18
factors affecting demand of myocardium
1. HR
2. contractility
3. systolic wall tension
19
