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Flashcards in coronary atherosclerosis & MI Deck (19)
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1

wat is the response to injury model for ASCVD?

1. endothelial injury
2. monocytes attach to endothelial cell
3. growth factors released
4. platelets may participate
5. complex lesions evolve over years

2

what is the Intimal collection of MACROPHAGES AND LIPID LADEN SMC’s?

fatty streak

3

what is the advanced lesion?

fibrous plaque

4

what is the MOST COMMON CAUSE OF DEATH IN DIABETIC PATIENTS

atherosclerosis

5

what is unstable angina

new onset, subjectively worse discomfort, onset with less activity, angina at rest

6

typically lasts LESS THAN 30 MINS, onset gradual, worsened by work & lying down

angina

7

stress testing is used to dx

atypical chest discomfort

8

when is stress testing not indicated?

asympt men or women

9

ST depression >2 on stress test is a certain dx of?

Myocardial ischemia

10

do beta blockers have any effect on O2 supply?

no, just reduce myocardial oxygen demand

11

what is a stable angina pectoris?

same pattern each time

12

stress testing can be used for prognosis of?

stable angina, post-MI, post-revascularization

13

what drugs can be used for pharmacological stress testing?

adenosine, dipyramidole, dobutamine

14

what tx for MI decrease pre-load, coronary dilation, enhance endothelial activity

nitrates

15

what tx for MI decrease HR and contractility

beta blockers

16

what tx for MI prevent spasms, reduction of afterload, some reduce contractility, DECREASE AFTERLOAD

CCB

17

factors affecting supply of myocardium

1. vascular resistance
2. coronary blood flow
3. O2 carrying capacity

18

factors affecting demand of myocardium

1. HR
2. contractility
3. systolic wall tension

19

when stress test is combined with ____, it increases the predictive power

imaging (echo or nuclear)