Flashcards in coronary atherosclerosis & MI Deck (19)
wat is the response to injury model for ASCVD?
1. endothelial injury
2. monocytes attach to endothelial cell
3. growth factors released
4. platelets may participate
5. complex lesions evolve over years
what is the Intimal collection of MACROPHAGES AND LIPID LADEN SMC’s?
what is the advanced lesion?
what is the MOST COMMON CAUSE OF DEATH IN DIABETIC PATIENTS
what is unstable angina
new onset, subjectively worse discomfort, onset with less activity, angina at rest
typically lasts LESS THAN 30 MINS, onset gradual, worsened by work & lying down
stress testing is used to dx
atypical chest discomfort
when is stress testing not indicated?
asympt men or women
ST depression >2 on stress test is a certain dx of?
do beta blockers have any effect on O2 supply?
no, just reduce myocardial oxygen demand
what is a stable angina pectoris?
same pattern each time
stress testing can be used for prognosis of?
stable angina, post-MI, post-revascularization
what drugs can be used for pharmacological stress testing?
adenosine, dipyramidole, dobutamine
what tx for MI decrease pre-load, coronary dilation, enhance endothelial activity
what tx for MI decrease HR and contractility
what tx for MI prevent spasms, reduction of afterload, some reduce contractility, DECREASE AFTERLOAD
factors affecting supply of myocardium
1. vascular resistance
2. coronary blood flow
3. O2 carrying capacity
factors affecting demand of myocardium
3. systolic wall tension