Endo 1 Flashcards
(60 cards)
how will TBG T3 T4 look like in a woman who is taking post menopausal hormone replacement
Estrogen increases TBG
increases TOTAL T3 T4
normal free T3 T4
euthyroid hyperthyroxinemia
total is high cause most of t3 t4 is bound to ybg
undergo nuclear translocation to act on zinc finger proteins and ultimately alter targeted-gene expression.
vitamin D3
steroids
estro
progestro
increase peripheral sensitivity to insulin by binding to and stimulating the activity of nuclear transcription factors called peroxisome proliferator–activated receptors.
thiazolinadones
glitazones
SE edema weight gain hepatotoxic and CI in heart failure as increase risk of MI
what drug do u give prior to pheochromocytoma ressection
irreversible alpha antag
SE can be miosis or pupillary constriciton
antidiabetic meds that decrease glucagon release
eexanetide pramlintide
GLP1 analogues
pancreatitis and hyhpoglycemoa
FSH works on?
granulosa cells to make estrogen
what would be the immediated effects of OCP that cause low FSH
low esttogen in follicular phase
essential amino acid to make thyroid hormones
tyrosine
arginine is a precursor of
NO
creatinien
urea
tryptophan precursor for
niacin (b6) and serotonin (bh4 and b6)
Glucagon and epinephrine act via the Gs pathway, leading to an increase in protein kinase A levels which in turn increases
fructose 2,6 bisphosphate
dysfunctional signal recognition particle (SRP).
Where is this signal sequence most likely located?
The signal peptide that sends a protein into the (endoplasmic reticulum) ER during translation is composed of a series of hydrophobic amino acids found at the N-terminus of the protein, and is recognized by the signal-recognition particle (SRP).
tumors of the adrenal medulla in adults and are derived from chromaffin cells, which arise from
neural crest
Pheochromocytomas may be associated with germline mutations such as those responsible for
MEN2A, MEN2B, von Hippel–Lindau disease, and neurofibromatosis type 1.
responsible for ADH production.
The supraoptic nucleus of the hypothalamus
he lateral nucleus of the hypothalamus is thought to be
hunger center” of the brain. Damage to this area leads to anorexia and starvation,
in hypoglycemia wat happens to glucose uptake into b celll
still takes place
glut 2 is insulin inependnt
what is neurophysin 1 used for
transport of oxytocin from paraventricular nucleus
ADH is transported by
neurophysin II
post pituitary hormones are made in
supraoptic nucleus … paraventricular nucleus
what is the treatment in primary hyperaldosteronism
spirinolactone
inhibits aldosterone
hypokalemai is mostly assoc with which type of acid base imbalacnce
metabolic alkalosis due to increased H+ secretion
how does spironolactone cause gynecomastia
en because it decreases testosterone production, increases peripheral conversion of testosterone to estradiol, and displaces estradiol from sex hormone-binding globulin
Hyperuricemia has been associated with use of
thiazide diuretics
