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2024 - élo - usmle rx qbank > resp onc 2 > Flashcards

resp onc 2 Flashcards

1
Q

pt with LHF … increased diastolic pressure

what happens to elastic recoil

A

increase recoil … decrease compliance

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2
Q

what does spontaneous pneumothorax do to all the lung capacities

A

DECREASE

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3
Q

what is vital capacity

A

total amount of air that can be exhaled

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4
Q

inc FRC inc TLC but decreased vital capacity

A

obstructive disease

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5
Q

biopsy of spleen reveals lymph node like structure with abnormal germinal centers ….+ve for CD 20 and BCL2

A

follicular lymphoma … t (14,18

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6
Q

overexpression of cyclin D

A

Mantle cell lymphoma … t (11,14)

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7
Q

B cell neoplasm …. overproduction of igM…. nose bleeds due to damaged vessels … igM increases viscocity of blood

A

waldernstrom macroglobulenemia

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8
Q

protein A binds Fc portion

A

staph aureus

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9
Q

moleculre mimicry caused by which virulence factor

A

M protein

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10
Q

zileuton mechanism

A

bock conversion of arachidonic acid to lipoxygenase 5

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11
Q

moteleukast

A

inhibit the leukotriene receptors

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12
Q

what is rb gene and how does it play a role in cancer devp

A

it is a tumor suppressor gene that normally inactivates E2F

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13
Q

pancreatic cancer gene mutation

A

p16

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14
Q

burning feet syndrome caused by which def

A

pantothenic acid b5

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15
Q

which synthetic steroid requires bioactivation

A

prednison

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16
Q

chemotherapy regimen for hodgkins

A

Adriamycine (doxorubicin)
Bleomycine
vinblastine
Dacarbazine

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17
Q

residents of a nursing hoime that have rhinorrhea, non productive cough, headaches, myalgias normally have what disease

A

influenza

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18
Q

late protein synthesis inhbitors

A

amprenavir

19
Q

viral adsorption inhib

A

gamma globulins … increase hep A immunity

20
Q

diffusion of oxygen into alveolar walls decreases in what condition

A

emphysema due to smoking , emphysema damages the alveolar walls

21
Q

decreased ability of hb to bind oxygen

A

sickle cell anemia of CO poisoning

22
Q

multiple nodular opacities that appear scattered throughout the peripheral lmph nodes and upper lobe

A

silicosis

exposure to rock mineral sand and smoking

23
Q

mucous gland hypertrophy and hyperplasisa seen in

A

bronchitis

24
Q

irregular non septate hyphae branching at 100 deg

A

mucor

25
Q

BRAF oncogene mutation

A

papillary thyroid carcinoma

26
Q

RAS

A

follicular thyroid carcinoma

27
Q

what pattern of lung disease is obesity assoc with

A

restrictive pattern due to the increased inward recoil of chest wall

28
Q

kidney transplant pt .. fever cough and acid fast stain shows long branching filaments

A

nocardia … txt with sulfonamides

29
Q

new bord with ARDS what do u do

A

treat with exogenous phosphatidylcholine although it does NOT reverse the pathology

30
Q

a child from congo … history of fever ,,, no vaccination ,,, right hip is externally rotated …inc WBC count….. aspiration of joint shows organism that grows on choclte agar not blood agar …. wht is the virulence factor of this organism

A

a capsule
H. influenza
signs of septic arthritis

31
Q

which cephalosporin has activity against pseudomonas

A

ceftazidime

32
Q

child irritable watery diarrhea and fever …. N myc oncogene

A

neuroblastoma … adrenal glands

33
Q

mutations of c kit gene

A

gastro stromal tumors

34
Q

C myc mutations

A

Burkitt lymphoma t 8 14

35
Q

primary prevention

A

interventions to prevent onset of the disease

36
Q

secondary prevention

A

identifying the asymptomatic disease in pt and stopping its progression

37
Q

tertiary prev

A

diagnosing the disease and treating it to reduce morbidity

38
Q

what is the function of surfactant

A

decrease alveolar surface tension and increase compliance

39
Q

mechanism cross link DNA and causes peripheral neuropathy

A

cisplatin

40
Q

increase number of mucous plugs and smooth muscle cell prolif

A

in ashma patients

41
Q

desquamation of resp epithelium

A

bronciectasis

42
Q

a drug that breaks DNA strands through free radical formation

A

bleomycin and causes p fibrosis

43
Q

pt presents with classic symp of influenza and gets treated with oseltamivir … starts feeling better but now has fever and coughing up green sputum… xray confirms lower lobe consolidation

A

this is bacterial pneumo after influenza inf

can be strept pyogenes (M protein), staph aureus, h influenza (capsule), strept pneumo (igA protease)

2024 - élo - usmle rx qbank (29 decks)

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