resp onc 10 11 Flashcards by Alexe Tousignant

flavivirus

hep c

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hepadena virus

hep b

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Chinese patients has liver mass … liver enzymes increased and complains of abd pain

hep b virus

C is usually asymptomatic and some sort of history with blood mixing shd be present (drugs tatoos etc)

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lisch nodules

NF 1 ch 17

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pt with shwanomas what else can u expect

NF2 ch 22 merlin gene

meningiomas, eye tumors and cataracts

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loss of parasympathetic fibers carried by CN III would cause

mydriasis

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atypical pneumonia what is the most sensitive method to identify the causative organism

mycoplasma

nasopharyngeal PCR

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long term treatment for asthma

B2 agonist long acting

Gs stimulation

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inhibition of protein kinase A

bbblockers

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mass in left frontal lobe … fried egg appearance

oligodendroglioma

oligocytes sued to myelinate central axons

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pt has burning senstation in mouth …. intermittent asthma … whitish film on tongue and inside cheeks … persistent day time cough and nighttime awakening
diag and txt

nystatin

candida infection …. pts with asthma can be txt with steroids that increases risk of candida infection

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Ascaris, hookworms, and pinworms.

albendazole

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terabinafine mechanism

inhibits squalene oxidase

txt for onnychomycosis

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whch medication decreases synthesis of estrogen and progesterone

leuprolide

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flutamide

antiandrogen …. blocks the androgen receptors

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abundant RER can be seen in which disease

Multiple myeloma … malignant prolif of plasma cells … plasma cells are differentiated B cells that can releas specific antibodies

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peroxisomes

fatty acid metabolism

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MM what can be seen interms of kidney

proteinuria

bence jones

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female itchy ulcerated lesion of the nipple

what underlying condition to check for

pagets disease
large halo like cells on histo
check for in situ or invasive ductal carcinoma

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can phyllodes tumors cause ulceration

yes but not eczematous rsahs

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hodkin lymphoma txt

ABVD
adramycin
bleomycin
vinblastine
dacarbazine

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cyclosproin

rmmber it is an immunesuppp

so use in autoimmune diseasea

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pt has CML … after txt he presents with crackles in lungs cough and dyspnea … what drug is causing these symp

busulfan … alkylating agent

imatinib is more linked with joint pain, edema, vomiting etc

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uterus larger than expected … BHG higher than expected… what is diag and complication

hydatiform mole ./…. choriocarcinoma

30 years old female …. knee pain... tender effusion and xray reveals distal epiphyseal lesion ,,,, nonsclerotic and sharply defined border

giant cell tumor | age 20-40 more common in women

younger boys and onion skin on xray … diaphysis of bone

ewings sarcoma t 11 22

tumor has bimodal age distribution …. grows on metaphysis of bone … codmans triangle periosteal shadow or sunburst appearanceq

osteosarcoma,a

which cells are the main responders in chronic bronvhitis

CD8 toxic t cells

Infiltration of eosinophils and CD4+ lymphocytes is characteristically seen

asthma

Necrotizing vasculitis and granulomatous eosinophilic tissue infiltration is characteristic of

eosinophilic granulomatosis churg strauss

appearance of a “pearly papule” with telangiectasias

BCC

Ziehl-Neelsen s

mycoplsma

n both CLL and SLL, the body produces high numbers of abnormal B-lymphocytes.

function in humoral immunity

pt in locked in state …. on ventilatot … daughter expresses her father didn't want to be kept alive on machines as a physician what do u do

respect autonomy | take offff ventilator

what other signs can be seen with tension pneumothorax

JVD due to increased intrathoracic pressure

Pancoast tumors noemally strangulate

second order preganglioninc sympathetic neuron that pass thru inferior cervical or stellate ganglion

first order sympathetic damage would occur in

lesion at level of cervical spinal cord, hypothalamus upper thoracic spinal cord

third order sympathetic involvement

injuries superior to thoracic cavty such as carotid dissection

retinoblastoma in a patient explain the mutation (I chose inherited)

rmmber Tumor suppressor genes require a two hit hypoth | so the first Rb was mutated but in order to get the cancer SPORADIC mutation of the other gene must take place

clearance of drug formula

0.7 x Vd /t1/2

tumor lysis syndrome lab findings

hypocalcemia with hyperphosphatemia, hyperkalemia, hyperuricemia txt allopurinol

ER +ve breast cancer in postmenopausal women .. after resection what drug do u place her on

aromatiase inhib | testost-estradiol

Hodgkin disease txt

BEACOPP cancer chemotherapy regimen: Bleomycin, Etoposide, doxorubicin (Adriamycin), Cyclophosphamide, vincristine (Oncovin), Procarbazine, and Prednisone.

C3b function

potent opsonin

IL3 function

like GM CSF prolif of myeloid lioneage

mediators of anaphylaxis

C3a C5a

abnormal prolif of metanephric blastema

Wilms tumor

malignant transformation of renal tubular cells

RCC

which electrolyte imbalance is closely related to disorientation and coma

hyponatremia

t 14 18 translocation

follicular B cell …. BCL2 on ch 18 is antiapoptotic

t 11 14

mantle cell lymphoma …. cyclin 1 in an oncogne

c myc activation

Burkitt … oncognene

what is defective in ataxia telengectasia

DNA repair mechanism

Noninflamed (or “cold”) skin abscesses , coarse facies and retained primary teeth

job syndrome … hyper igE

ttp eczem recurrent infc

wiskot Aldrich

cystic enlargement of the liver, berry aneurysms, hypertension, and mitral valve prolapse.

APKD

childhood supratentorial tumor and presents with headaches and bitemporal hemianopia

craniopharyngioma

Waldenstrom macroglobulinemia typically presents with hyperviscosity syndrome, adenopathy, and hepatosplenomegaly

also IgM

BCR-ABL is a 9;22 chromosomal fusion resulting in constitutively active tyrosine kinase.

this is an activation of proto oncogene