Endo/Repro Drugs Flashcards Preview

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Flashcards in Endo/Repro Drugs Deck (31):
1

terbutaline

b2 agonist
- activate adenylel cyclase -> raise cAMP-> phosphorylatase-> MLCK blocking

tocolytic
-suppress uterine smooth muscle

IV or PO

2

Ritodrine

b2 agonist
-activate adenylel cyclase -> raise cAMP -> phosphorylatase-> MLCK blocking

tocolytic
- suppress uterine smooth muscle

3

Magnesium Sulfate

tocolytic
IV
Competes w/ Ca and relaxes Smooth Muscle

Prevent seizures

4

Atosibane

Ocytocin receptor ANTAGONIST

delays labor

5

Pitocin

Oxytocin synthetic

oxytocic

Gq

Uterine contractions, milk let down, ADH and vasoactive and high concentrations



NO oral

6

Dinoprostone

prostaglandin (E)- hyperalgesia
oxytocic

softening of cervix
uterine contrations

abortifacent - vaginal suppository
- hydratiform mole

Gs

7

Carboprost

prostaglandin (F)
oxytocic

Uterine contractions

abortifacent
- IM

Gq

8

misoprostol

prostaglandin(E)
oxytocic

Softening of the uterus
uterine contractions

Vaginal or Oral
used / progesterone antagonist - mifepristone


Gs

9

Ergonovine

ergot
oxytocic

contraction of the uterus(NOT USED)
and postpartum bleeding

alpha adrenergic, dopaminergic and 5HT2 receptors

10

Ergotamine

ergot

Contraction of blood vessels - more for migraine HA

11

Indomethacin

reduces oxytocin induced uterine contractions

12

oxytocin receptor

Gq protein -> phospholiase C -> increased Ca

Need Mg and Cholesterol allosteric

13

Goserelin

GnRH analogue
-flare of symptoms before down regulation of receptors

prostate and ER + cancer (pre menopause)

low testosterone problems...

14

Leuprolide

GnRH Analogue
-flare of symptoms (given w/ flutamide) before down regulation of receptors

prostate and ER + cancer (pre menopause)

Low testosterone problems...

15

Degarelix

GnRH competitive antagonist

NO surge, much faster
in prostate and assister repro use

Shorter duration of action -> cost and compliance

Class promotes histamine release -> hypotension and allergic rxns, rash

16

Dutasteride

5 alpha reductase inhibitor

Testosterone -> DHT blocked

Used for BPH and baldness, prostate CA prevention

teratogenic

17

finasteride

5 alpha reductase inhibitor

Testosterone -> DHT blocked

Used for BPH and baldness, prostate CA prevention

teratogenic

18

Aminoglutethimide

Aromatase inhibitor- nonsteriodal/reversible

cholesterol -> pregnenolone (higher up)

Can mimic Adrenal Insufficiency
-myelosuppression

19

Anastrozole

aromatase inhibitor - nonsteriodal/reversible

testosterone ->estradiol in ovary (pre meno)

androstenedione -> estrone in adipose (POSTmeno)

polyarthralgia
bone density
Better lipid?

20

letrozole

aromatase inhibitor -nonsteriodal/reversible

testosterone ->estradiol in ovary (pre meno)

androstenedione -> estrone in adipose (POSTmeno)

polyarthralgia
bone density
better lipid?

21

Bicultamide

Anti androgen receptor

ADT therapy - Prostate
- given to fight flare w/ GnRH agonists( still have high testosterone but no effect)

Inhibit ligand binding and translocation

Not used long term or alone

22

Flutamide

Anti androgen receptor

ADT therapy - prostate
-given to fight GnRH agonist flare (still have high testosterone but no effect)

Inhibit ligand biding and translocation

not used long term or alone

older more side effects - gynectomastia, liver function, Diarrha, N/V, low testosterone effects

23

Nilutamide

Anti androgen receptor

ADT therapy - prostate
-given to fight GnRH flare (still have high testosterone but no effect)

Inhibit ligand binding and translocation

not used long term or alone

24

Raloxifene

anti estrogen(SERM)

oral, peaks hrs
NO benefit after 5 yrs

Good for all 3 - breast antagonist, uterus antagonist, bone agonist

25

tamoxifen

anti estrogen(SERM)

oral, peaks hrs
no benefit after 5yrs
GO TO drug for ER +

prevention of invasive carcinoma

Good: Breast antagonist, bone agonist

Given w/ GnRH analogue - due to inhib negative feedback (higher estradiol w/out)

Bad: Uterus agonist - endometrial CA

Also stroke risk

26

toremifene

Anti estrogen(SERM)

oral, peaks hrs
no benefit after 5 yrs

Good: Breast antagonist

Bad: Uterus agonist

27

Fulvestrant

anti Estrogen (SERD)

IM, peaks 7 days

Cyp3A4 concern

Competitive antagonist in EVERY tissue - hard on bone...

back pain, HA, phayngitis, GI

28

FAC regiment (1st)

5 fluoruacil
-anti metabolit

Adriamycin -doxyrubicin
-anthracycaline
-cardiotoxicity and local necrosis

cyclophasphamide
- alkylating agent
- hemorrhagic cyst worries

29

CMF regiment (2nd)

Cyclophosphamide

Methotrexate
- switch out of doxyrubacin when toxicity met

5 fluoruracil
-antimetabolite

30

Traztuzumab

Ab against HER2 surface marker

31

Paclitaxel

binds to tubulin to enhance and stabilize spindle formation