IHO Cancer Flashcards Preview

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Flashcards in IHO Cancer Deck (41):
1

RET

neural growth factor receptor, MEN2A andMEN2b

2

KIT

Stem cell growth factor receptor, GI stromal tumor

3

ERBB/HER2

Epidermal growth factor receptor; amplification, breast carcinoma

4

PDGFB

Platelet derived growth factor; over expression; Astrocytoma

5

RAS (3 cancers)

GTP binding protein - sig transduction, Carcinoma, melanoma, lymphoma

6

ABL (2 types)

Tyrosine Kinase - sig transduction; 9:22 w/ BCR, CML and some ALL

7

c-myc

Transcription factor; t(8;14) of IgH; Bukitt lymphoma -

8

t(9:22)

CML and some AML
Tyrosine kinase

9

t(8:14)

Burkett Lymphoma - starry sky
14-IgHeavy chain
8- c-myc nuclear regulator

10

n-myc

transcription factor, Amplification, Neuroblastoma

11

l-myc

Transcription factor, Amplification, Lung carcinoma, small cell

12

t(11;14)

Mantle cell carcinoma
14-Ig
11-cycD

13

CDK4

Cyclin dependent kinase; cell cycle reg; amplification, Melanoma

14

Top 3 cancer by death -

Lung, breast/prostate, colorectal

15

Top 3 cancer

Breast/prostate, lung, colorectal

16

Afalatoxins carcinogen

hepatocellular carcinoma, aspergillus

17

Alkylating agents carcinogen

leukemia/lymphoma

18

arsenic carcinogen

Squamous cell skin, lung, angiosarcoma

19

asbestos carcinogen

lung carcinoma, mesothelioma

20

Nitrosamines carcinogen

Stomach cancer, smoked foods

21

naphthyalamine- carcinogen

urothelial carcinoma bladder

22

vinyl chloride carcinogen

angiosarcoma, PVC exposure

23

nickel, chromium, beryllium ,silica carcinogen

lung carcinoma

24

EBV carcinogen(3)

Nasopharynx, Burkitt lymphoma, CNS lymphoma

25

HHV8 carcinogen

Kaposi sarcoma

26

HBV/HCV carcinogen

hepatocellular carcinoma

27

HTLV1 carcinogen

adult t cell leukemia/lymphoma

28

HPV carcinogen(2 cancers) (3 high risk groups)

squamous cell carcinoma and adenocarciona of cervix - 16, 18, 31

29

Radiation(ionizing) carcinogen (3)

AML, CML, Papillary carcinoma of thyroid (unique)

30

Nonionizing radiation carcinogen(UVB) - (3)

basal cell, squamous cell, melanoma

31

p53

regulates G1-S phase, upregulates BAX to disrupt Bcl2 and induce apoptosis

32

Bcl2

Maintains mitochondria membrane, cytochrome C escapes induce apoptosis

33

Rb

holds E2 TF, necessary for S phase, phosphorylated to bbs released by Cyclin D; mutations retinoblastoma and osteosarcoma

34

E2f

transcription factor

35

t(14:18)

follicular lymphoma, Bcl2 is over expressed;
14-Ig
18- BCL2

36

Tumor marker - bone METS, liver and Pagets disease

alkaline phosphatase

37

Tumor marker beta hCG seen in (2)

Hydratiform moles
Choriocarcinomas

38

Ovarian cancer tumor marker

CA-125

39

Melanoma, neural tumors and schanomas have this tumor marker

S-100

40

Hairy cell Leukemia diagnosis stain and smear

Stains TRAP - tartate- resistant acid phosphatase

Cells have filmentous hair like projections

41

Hairy cell Leukemia symptoms

Pancytopenia - unique
Splenomegaly
cells w/ "hair"

affects middle age men