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Flashcards in Side Effects pharm Deck (83):
1

Digoxin
SFX

ECG -dysrythia: paroxysmal tachy, 2:1 heart block

Cholinergic

Abx: normalize K levels

Does not cause hypokalemia, BUT co-presence can lead to decampment of toxicity, heart is overly sensitized to digoxin's effects

2

Gynectomastia inducing drugs(5)

Some drugs create awkward knockers

Spiranolactone
Digitalis
Cimetidine
Alcohol
Ketokonazole

3

Cimetidine (3)
SFX

Inhibits cytochrome p450
antiadronogenic effects
cross BBB

4

Antibiotics to Avoid in pregnancy
(8)

SAFe Children Take Really Good Care

Sufonamides - kernicterus
Aminoglycosides -otoxicity
Flouroquinolones - Cartilage damage
Clarithromycin - embryotoxic
Tetracyclines - disolored teeth, inhib bone growth
Ribavirin - teratogenic
Griseofulvin - tertogenic
Chloramphenicol - gray baby

5

Celecoxib problem that is not w/ other NSAIDs

sulfa allergies

6

trazadone

SFX

trazaBONE

priapism, postural hypersensitivity, sedation, nausea

7

Buproprion

SFX

Siezure in buliemic patients

sitmulant effects

8

Mirtazapine
SFX

increases appetite and dry mouth

9

Category X drugs (6)

SFX

methotrexate- folate deficiency
isotreinism -spontaneous abortion, HoxD13
warfarin - spontanteous abortion
statin - CNS/ limbs
Thalidomide - limbs
DES - clear cell vaginal adenocarcinoma

10

Heart and limbs develop around

week 4

11

Genetalia develop around week

week 10

12

Fetal movement begins

week 8

13

Abx to stop if pregnant

tetracycline - teeth
aminoglycosides - ototoxicity
floroquinoones - bones

14

seizure disorder and pregnant - stop what 3 drugs

phenytoin
valproic acid
arbamesepine

15

Hypertension medication to stop in pregnancy

ACE inhibitors - renal damage

16

Drugs that induce P450? (7)

Coronas, Guiness and PBRS lead to CHRONIC ALCHOLSIM

Carbamazapine
Griseofulvin
Phenytoin
Barbiturates
Rifampin
St Johns Wart
Chronic alcoholism

17

Drugs linked to steven Johnson Syndrome (8)

Anti epileptics
- ethosuxamide
-lamotriginine
-carbamazepine
-phenytoin
-phenobarbitol
Abx:
-sulfonamides
-penicillins
Allopurinol

18

Drugs linked to Agranulocytosis(5)

Carbamazepine - siezure
clozapine - antipsych
colchicine - gout
propothiouracil and methimazole - antithyroid

19

Blood dysrasia seizure medication (2)

carbamazipine
ethosuximide

20

Cutaneous Flushing drugs (4)

VANC

Vancomycin
Adenosine
Niacin
Ca channel blockers - Amlodipine, nefidipine

21

Coronary Vasospasm drugs (5)

Cocaine
Sumatriptans
ergot alkaloids
amphetamine
methamphetamine

22

Dilated cardiomyopathy SFx (2)

Doxorubicin - adriamycin
daunorubicin

23

Torsades de Pointes SFx Drugs(6)

Rx w?

Macrolides
haloperidol
chloroquine
protease inhibitors
Class III - K channel blockers (Amniodarone)
Class IA - Na channel blockers (quinidine)

24

AgranuloCytosis SFx Drugs (6)

Clozapine
Carbamazapine
Colchacine

Propylthiouracil
methimazole

dapsone

25

Aplastic Anemia (5)

Chloramphenicol
benzene
NSAIDs

propylthiouracil
methimazole

26

Grey baby syndrome

Pathogenesis

Chloramphenicol

low UDP glucoronyl transferase low in babies

27

anemia (hemolysis) in G6PD SFx

isoniazid
Sulfonamides
Primaquine
HIGH ASA
Ibuprofen
Nitrofuranitoin
Dapsone
Fava Beans
Naphalene

28

Why are we worried about OCPs in smokers over 35?

Risk of thrombotic complications

29

Thrombocytopenia Drug SFx (2)

Heparin
Cimetidine

30

Pulmonary Fibrosis Drug SFx (3)

Amiodarone - Check LFTs, TFTs, PFTs

Bleomycin
Busulfan

31

Cough due to a medication

due to

Ace inhibitors

Bradykinin

32

Hepatic Necrosis drug SFx(4)

Halothane
Amantia phalloides - mushroom
Valproic acid
Acetaminophen

33

Hepatitis Drug SFx (1)

Isoniazid

34

Pseudomembranous colitis (3)

clindamycin
ampicillin
amoxicillin

35

Hot flashes SFx(2)

Tomoxifen
clomiphene
(SERMs - > high LH and FSH levels)

36

Adrenocortical insufficiency

corticosteriod withdrawal

37

Hypothyroidism drug SFx (3)

Lithium
amiodarone
sulfonamides

38

Gout exacerbation drug SFx (5)

Furosimide
thizazide
niacin
cyclosporine
pryazinamide

39

Gingival hyperplasia Drug SFx (2)

*Phenytoin

verapamil

40

Osteoporosis Drug SFx (2)

corticosteroids

heparin

41

Photosensitivity Drug SFx (2)

SATs for PHOTO

Sulfonamides
Amiodarone
Tetracycline

42

Stevens Johnson Rash Drug (4)

Penicillin
sulfa drugs
allopurinol
Anti siezure
- ethosuximide
-carbamazepine
-lamotrigine
-phenytoin
-phenobarbital

43

Drug induced SLE (5)

SHIPP

Sulfonamides
hydralazine
INH
Procainamide
Phenytoin

44

Tendonitis and rip in tendon drug SFx

fluoroquinolones

45

Diabetes insipidus Drug SFx (2)

Lithium
demeclocycline

46

Fanconi's syndrome Drug SFx (2)
-What is it?

expired tetracycline, heavy metal exposure

proximal tube defect leading to spillage of required items

can also be caused by wilsons disease

47

Interstitial nephritis Drug SFx (3)

Abx (methicillin)
NSAIDs
furosemide

48

Cinchonism

What is it?

What drugs are associated? (2)

Dizziness w/ HA, vision changes and tinnitus

Quinidine (class IA antiarrythmic) and quinine

49

Parkinson like symptoms Drug RXn (3)

Lowering Dopamine
antipsychotics
reserpine (packages)
metoclopramide (given for gastroparesis maybe?)

50

Seizure inducing drugs(5)

isoniazid
Buproprion
Imipenem/cilastatin
Tramadol
Metoclopramide

51

Tardive Dyskinesia

antipsychotic

52

Antimuscarinic SFx (4)

Atropine
TCAs
H1 blockers
Neuroleptics - thiordazine, chlorpromazine

53

Nephrotoxicity w/ ototoxicity(4)

Aminoglycosides
vancomycin
loop diuretics
cisplatin

54

nephrotoxicity w/ neurotoxicity (3)

aminoglycosides*
cisplatin*
polymixin

ototoxic as well

55

Methanol in the body is converted to what toxic metabolite

formaldehyde

56

Ethylene glycol in the body is converted to what tosco metabolite

oxelic acid

57

Acetaminophen toxicity?

works by?

n acetycysteine

replenishing glutathione that helps w/ NPAQI metabolites that damage hepatocytes

58

presentation of N/V dizzy and tinnitus - overdose of?

Rx?

ASA

NaHCO3

59

Presentation of bad teeth and anxiety and confusion, excitability?

Rx

Methamphetamine

NH4Cl

60

Antimuscarinic overdose (dry as a bone, blind as a bat )
Rx?

physostigmine

61

overdose of verapamil and beta blocker -> bradycardia

Rx (3)

Glucagon -> increases cAMP in myocardium
atropine
Ca

62

Digitalis overdose see?

Rx(2)

arrythmia and electrolyte imbalance

Anti dig Fab
normalize K

63

Kid eats too many vitamins worry of what?

Symptoms of Ab pain, hematuriosis, melana, lethargy

Rx?

Iron overload

DeFeroxamine,

DeFerasirox

64

Kid with developmental delays, basophilic stippling, nonspecific GI worry of?

Rx?(3)

Lead poisoning

Dimercaperol, EDTA, Succimer

65

Mercury, arsenic or gold poisoning Rx?(2)

Dimercaperol

Succimer

66

Copper, Arsenic, gold Rx

Penicillamine

67

Patient comes from a house fire and maybe has cyanide poisoning

Rx ?(3)

nitrites
thiosulfate
hydroxocobalamin

68

Methemoglobin Rx (2)

Methylene Blue

Vitamin C

69

Patient presents w/ very red lips and uses a kerosine lamp to heat his car worry of?

Rx?

Carbon monoxide poisoning

100% O2

70

Methanol or ethylene glycol poisoning Rx

Fomeprizol

Ethanol also

71

Benzodiazapine overdose Rx?

Worry of

Flumazenil

Seizures

72

OPiods in a mother prior to labor and she delivers early, give what to the baby?

Naloxone

73

TCA overdose?

NaHCO3 - alkalize the urine

74

Heparin overdose?

Protamine

75

Warfarin overdose initially and over time?

FFP if quick

vit K 3-5 days

76

TPA, Streptokinase and urokinase overdose Rx

aminocaproic acid

77

Thophylline overdose see?

Rx?

Tachy, arrhythmic - narrow TI

beta blocker

78

Drugs that SHOULD NOT be given to sulfa allergy patients(8)

Celecoxib
sulfonamides - TMP-SMX
acetazolamide - carbonic anhydrase inhib
Loop diuretics - furosemide
Thiazide diuretics
Probenacid - gout excreter
Sulfonylureas - DM II
sulfasalazine - Ulcerative colitis

79

Sulfa Drugs Frequently Cause Terrible Acute Symptoms

Sulfasalazine /(TMP-SMX)
probenaciD
Furosemide (loops)
Celecoxib
Thiazide
Acetazolamide
Sulfonureas

80

Side effects of Sulfonamides(6)

hypersensitivity*

hemolysis w/ G6PD def

nephrotoxixity - tubointerstial nephritis

photosensitivity

kernicterus in infants (N overload peri-birth)

displacement from alumin (warfarin)

81

TMP-SMX indications(4)

UTI
Shigella
Salmonella
Pneumocisitis jirovecii
-prophylactic <200 CD4

82

TMP-SMX toxicity(3)
-TMP concerns

megaloblastic anemia
leukopenia
grancytopenia

Rx- folic acid rescue - leucovorin

83

Floroquinalone concerns (3)

tendonitis
-tendon rupture
Contraindicated in pregnancy and kids due to hardness on articular cartilage