IHO Disease Flashcards Preview

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Flashcards in IHO Disease Deck (14):
1

HLA DR3/Dr4

increased risk of DM1

2

Heinz body -
what is it ?
what is it seen in (2)?

oxidized hemogobin w/in RBC

seen in G6P dehydrogenase deficiency and thallasemia

3

Red urine w/out RBC

hemoglobinuria

4

nuclear elements in RBC

Holly Jolly bodies, seen post splenectomy

5

Seronegative Spondyloarthropathies - Arthritis w/out rheumatoid factor - no anti Ig Ab (4)

PAIR - HLA B27 associated

Psoriatic Arthritis - joint pain w/psoriasis

Ankylosing spondylitis - bamboo spine

Inflammatory Bowl Disease - Crohns and UC

Reactive Arthritis(Reiter Syndrome) - Conjunctivitis, Urethritis, Arthritis

6

Primary Amyloidosis - seen and associated w/

AL systemic deposition
-Ig light chain derived

Plasma cell dyscrasias - multiple myelinoma

7

Secondary Amyloidosis - seen and associated w/

SAA -> AA systemic deposition
-acute phase reactant increased in chronic inflam states and Familal Mediterranium Fever

Nephrotic syndrome - kidney most common
Restrictive cardiomyopathy
Tounge enlargement, malabsorbtion, arrhythmia

8

Senile Cardiac amyloidosis

serum non-mutated transthyretin in heart, usually asymptomatic
>80 yrs

9

Familal amyloid cardiomyopathy

serum mutated transthyretin deposits -> restrictive cardiomyopathy

African americans

10

Alzheimer disease amyloid type and who has higher risk?

A beta
depostis in brain forming plaques

Beta APP on chromosome 21 making down at increased risk

11

Dialysis associated

beta2 microglobulin
not filtered well and builds

12

Medullary Carcinoma

calcitonin deposits within tumor

tumor cell in amyloid background

13

hemolytic anemia, pancytopenia and venous thrombosis think of?

More often seen?

Paroxysmal nocturnal hemoglobinuria

Seen in the morning

14

Paroxysmal nocturnal hemoglobinuria due to ?

increased complement mediated RBC lysis

-missing decay accelerating factors (CD55/59)
or
- decreased synth of GPI anchor (PIG-A)